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Mind Your Meds: Timing is Everything!
What percentage of hospitalizations do you think are caused by medication issues: 10% maybe 25%? Believe it or not 40%! That's almost half of all hospitalizations which could potentially be avoided! Let's look at just a couple of common pitfalls. Generic Versus Name Brand: Lynda has a history of high blood pressure and her doctor prescribed metoprolol 50 mg twice daily. She went into the hospital for gall bladder surgery and was discharged home with a prescription for Lopressor 50 mg twice daily. Upon returning home, she resumed her metoprolol dose and began taking Lopressor as well. What she did not realize is that metoprolol is the generic version of Lopressor which means she was suddenly taking a double dose of her blood pressure medication. She was back in the hospital only days later because of a fall due to low blood pressure. Solution: Anytime a new medication is prescribed be sure to inform your provider of ALL medications you are currently taking and make sure there are no conflicts or overlapping meds. Don't forget to mention over the counter meds and vitamins too! Timing: If a medication is prescribed more than once per day, the amount of time between doses is very important. Upon returning home from the hospital, the second time, Lynda was now only taking metoprolol twice daily so she thought she was on the right track. She would take her second dose with her supper at 5:00. Her next dose would not be until she woke up the next morning around 8:00. This meant that there were 15 hours between doses! It is no surprise that he was waking up each morning with a headache and high blood pressure. After a particularly stressful morning, she decided she would go to the emergency room. Solution: Make sure to space your medications as evenly apart as possible so there are not big gaps between doses. By simply moving her last dose to bedtime instead of with supper, Lynda was able to wake up feeling great! In Lynda's case, the cost of simple medication errors really added up when you calculate the stress anxiety and financial impact of two avoidable hospitalizations. If you're lucky enough to have a TeleHealth Coach through CareCycle Solutions, you know that these are exactly the kinds of clues we are watching for 24 hours a day. Are you overwhelmed with Minding Your Meds? We Have a Solution. Go to www.CareCycle Solutions.net and print the "Mind Your Meds" Hints for Health sheet on Medication Management.
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Lipitor Side Effects
Educate yourself about the side effects of using lipitor at http://lipitorside-effects.com
Просмотров: 1679 Paul Kerr
Beta blocker Nebivolol (srrr form) in the binding pocket of beta-2 receptor
Beta-adrenergic receptors have many vital physiological functions: for example, beta-1 receptors are important for the contractility of heart muscle, beta-2 for lungs and beta-3 for adipose tissue. Due to their importance, beta receptors are natural targets for drug development. beta-1 blockers, atenolol, are used treatment of cardiac arrythmias and congestive heart disease. Beta-2, as it is important in lungs, is a target for asthma treatment. Salbutamol being one of the most common ones. Nebivolol is a fairly new beta blocker. It binds selectively to beta-1 receptors and it is used in treatment of hypertension. Nebivolol is the most selective beta-1 blocker. The origin of selectivity is, however, poorly understood. Our aim here is to investigate the molecular origin of this selectivity. This was done by combining large scale molecular dynamics and molecular docking studies using the beta-2 receptor with nebivolol. Our study shows that water has a very important role determining binding affinity. This is, to our knowledge, the first demonstration of the importance of water in beta-blocker binding. We used two optical isomers of nebivolol, the so-called ssss- and srrr-forms and the interactions with water turned out to be the decisive factor in the better binding of the srrr-form. The movies shows a nebivolol molecule (red) in the binding pocket of a beta-2 receptor. The receptor is embedded in a lipid membrane (shown in green) and we have zoomed into the region of the nebivolol-receptor interaction. The slow motion of hydrating water (purple) is very clear. Reference: Molecular docking, multiple sequence alignment and atomistic molecular dynamics simulations reveal residues associated with selective binding of beta-blockers to human beta-1 and beta-2-adrenergic receptors, K. Kaszuba, T. Rog, K. Bryl, I. Vattulainen, and M. Karttunen, J. Phys. Chem. B 114, 8374-8366 (2010) http://dx.doi.org/10.1021/jp909971f
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How to Pronounce Olmesartan
Learn how to say words in English correctly with Emma Saying free pronunciation tutorials. Over 140,000 words were already uploaded... Check them out! Visit my homepage: http://www.emmasaying.com
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How to Pronounce Synthroid
Learn how to say words in English correctly with Emma Saying free pronunciation tutorials. Over 140,000 words were already uploaded... Check them out! Visit my homepage: http://www.emmasaying.com
Просмотров: 2735 Emma Saying