A New Era in Precision Medicine
Faculty: Linda B. Ford, MD, FACAAI, FAAAAI, AE-C; Neil R. MacIntyre, MD; Michael E. Wechsler, MD, MMSc
This Clinical Research Updates™ program addresses the needs of allergists/clinical immunologists, pulmonologists, and other clinicians involved in the ongoing management of patients with severe asthma. Asthma is a chronic respiratory disease that affects more than 300 million people globally and more than 25 million adults and children in the United States. There is an urgent need to improve the care of the estimated 5% to 15% of these patients who have severe asthma, which accounts for an outsized proportion of the disease’s morbidity, mortality, and healthcare costs. Indeed, heterogeneity in the clinical development and manifestations of asthma—amplified by such factors as symptomatic variability and common comorbidities—often leads to an underestimation of disease severity and markedly hinders the achievement of guideline-recommended treatment goals. Efforts to overcome these hurdles will be aided by the growing number of biomarkers for asthma diagnosis, classification, and control, as well as the expanding classes of targeted biologic therapies. In this Clinical Research Updates™ program, a panel of expert pulmonologists and clinical immunologists discusses various approaches for identifying asthma phenotypes and endotypes to inform individualized therapeutic decision-making. The panel also reviews key presentations from the American Thoracic Society’s 2016 International Conference, translating new data into actionable advice on how current best practices are changing with the quickly evolving treatment landscape.
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