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Tinnitus: Ringing in the Brain | Josef Rauschecker | TEDxCharlottesville
In this talk Josef Rauschecker illuminates the science behind tinnitus as well as the current state of treatment options. Josef Rauschecker has 35 years of experience in systems and cognitive neuroscience, more than 25 years of experience in animal electrophysiology, and upwards of 15 years of experience with functional magnetic resonance imaging (fMRI). At Georgetown University Medical Center, he helped create the first human fMRI research facility. He has also held visiting appointments at several institutions, including Harvard Medical School, and has been the recipient of a Humboldt Award and a Finland Distinguished Professorship. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at http://ted.com/tedx
Просмотров: 446824 TEDx Talks
William Catterall (U. Washington) Part 1: Electrical Signaling: Life in the Fast Lane
https://www.ibiology.org/neuroscience/sodium-channels/ Lecture Overview: How does a baseball player react quickly enough to hit a 90 mph fastball or a tennis player to hit a 60 mph serve? All of the fast events in our bodies, such as vision, hearing, nerve conduction and muscle contraction, involve electrical signals. In Part 1 of his talk, Dr. Catterall explains how the flow of sodium and potassium ions, through specific channels in the cell membrane, creates an electrical signal in nerve and muscle cells. He describes the structure and function of the sodium channel and its important role in physiology and pharmacology. In Part 2 of his talk, Catterall describes how voltage gated sodium channels function at an atomic level. Bacterial Na+ channels in the NaChBac family contain many of the elements of mammalian Na+ channels but in a much simpler form. Using X-ray crystallography to study NaChBac proteins, Catterall and his colleagues determined which domains of sodium channels are responsible for sensing voltage differences across the cell membrane and how these domains trigger the opening of the channel pore. It was also possible to identify the structural changes leading to the slow inactivation of channels after multiple rounds of opening and closing and to understand how NaChBac establishes its specificity for Na+ ions. In his third talk, Catterall switches his focus to voltage gated calcium channels. Na+ and Ca2+ channels share a common ancestor and consequently, much of the overall structure of the voltage sensing domain and the central pore is conserved. In spite of this homology, the calcium channel selects specifically for Ca2+ ions, even in the presence of an excess of Na+. Upon entry into the cell, Ca2+ ions regulate numerous intracellular processes. Catterall explains how his group was able to engineer a bacterial calcium channel that allowed them to identify the residues required for Ca2+ selectivity. He also describes experiments demonstrating that Ca2+ ions act locally within the cell, allowing for targeted regulation of cellular functions such as learning and memory in the brain and contraction in skeletal and cardiac muscle. Speaker Bio: Bill Catterall is Professor and Chair of the Department of Pharmacology at the University of Washington where he has been a faculty member since 1977. Catterall received his BA in Chemistry from Brown University and his PhD in Physiological Chemistry from Johns Hopkins University. He was a post-doctoral fellow with Dr. Marshall Nirenberg and a staff scientist at the NIH for a few years before moving to the University of Washington. Catterall and his colleagues discovered the voltage-gated sodium and calcium channels responsible for generating the electrical impulses necessary for most physiological functions. His lab continues to study the structure and function of these channels, their physiological regulation, and their interaction with medically important drugs. Catterall is also interested in understanding how impaired channel function may lead to human disease. Catterall has been recognized with numerous awards and honors for his contributions to the fields of electrophysiology, pharmacology, neuroscience, and cell biology. These include receiving The Bristol-Myers Squibb Award for Distinguished Research in neuroscience in 2003, The Gairdner International Award of Canada in 2010, election to the U.S. National Academy of Sciences in 1989, the Institute of Medicine and the American Academy of Arts and Sciences in 2000, and as a Foreign Member of the Royal Society of London in 2008.
Просмотров: 9386 iBiology
Warning: Dangerous Fish Oil Omega 3 Side Effects
4 IMPORTANT steps to follow: 1. Make sure that the supplement is made in the USA or Europe. 2. Make sure that it has DHA docosahexaenoic acid in it. It is an expensive but important ingredient and cheap, low quality manufacturers avoid it. 3. Certified certified and CERTIFIED always use certified food supplements - it is your quality guarantee. 4. You know that high quality fish is expensive. Quality fish oil capsules should cost at least 35-40$ per bottle (50-60 caps.). If that would put you to an uncomfortable situation financially please look for another supplement. Brands I trust and recommend to my patients and friends/family. 1. http://www.healthyware.com - I've been buying their supplements for my family for years and I must say they always deliver what they promise - quality. The only unpleasant problem with them is that due to their popularity they are often out of stock. Their official website is http://www.healthyware.com Omega three fish oil is healthy choice for everyone. Nonetheless fish oil minor side effects can happen if you take it in too high applications. One of the most typical side-effects is that fishy belch that leaves a particularly upsetting taste in one's mouth. Even, in small dosages, this fishy belch can happen. The nice news is this is fixable. When you purchase the proper quality omega3 supplement, you need to get that upsetting belching or fish breadth. Another possible complication is bleeding. Higher doses can end up in nose bruising and bleeds. This is due to the fact that this particular product can forestall the blood from clots. Taking the incorrect sort of fish oil, specifically cod liver oil, can cause over consuming of A vitamin. Vitamin is an exceedingly full of cod liver oil. Taking an excessive amount of may cause liver damage, dry skin and headaches. So once more, it's very important the best quality of omega 3 fish oil be used. Diarrhea is an additional possible consequence of over intake of this particular supplement. One of the most important concern about using this particular supplement may be the pollutants that could be inside a capsule. This amount of fishes live in polluted waters, those contaminants are moved through the fish towards the omega-3 fatty acids capsule. Then when you are taking a capsule, you might be eating dangerous pollutants like mercury and lead which can do serious damage to your fitness But again, by consuming the right quality product, it'll be unnecessary to fret about consuming these pollutants. Why? Because they will not be in it. It would've been removed by the processing. Cod liver oil sadly isn't of the right quality. Bottom line, be careful about what type of fish you obtain your fish oil from and your dosages. Taking about 6 a day is counseled for getting the wonderful health benefits and not one of the minor side effects. fish oil side effect fish oil side effects side effects fish oil fish oil side effects acne fish oil side effects bleeding fish oil side effects bloating fish oil side effects children benefits of fish oil capsules best fish oil capsules carlson fish oil capsules eskimo 3 fish oil capsules fish oil capsules fish oil capsules 1000 mg fish oil capsules 1000mg fish oil capsules 1200 mg fish oil capsules 1400 mg fish oil capsules 2000 fish oil capsules acne fish oil capsules and weight loss fish oil capsules benefits fish oil capsules burpless fish oil capsules calories fish oil side effects constipation fish oil side effects depression fish oil side effects diarrhea fish oil side effects dogs fish oil side effects fish oil dosage fish oil side effects fish oil supplements fish oil side effects gas fish oil side effects headache fish oil side effects in dogs fish oil side effects in men best fish oil carlson fish oil fish oil fish oil (omega 3) side effects fish oil 1000mg fish oil and cholesterol fish oil benefits fish oil benefits and side effects fish oil capsules fish oil capsules damage your liver fish oil depression fish oil dosage fish oil dosage for dogs fish oil for dogs fish oil for kids fish oil capsules fish oil health benefits fish oil liquid
Просмотров: 344699 Maria Clifford
Research Directions in Stevens-Johnson Syndrome Toxic Epidermal Necrolysis - Teri Manolio
September 21, 2015 - National Advisory Council for Human Genome Research More: http://www.genome.gov/27562458
Просмотров: 822 National Human Genome Research Institute
Group 1: Basic Research Working Group Report - Lauren Trepanier and Wen-Hung Chung
March 3-4, 2015 - Research Directions in Genetically-Mediated Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis More: http://www.genome.gov/27560487
Просмотров: 132 National Human Genome Research Institute