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Say No to Bisphosphonates
Say No to Bisphosphonates Bisphosphonates cause a systemic subclinical toxicity which may erupt as osteonecrosis. Bisphosphonates are structural analogues to calcium pyrophosphate in bone and bind to calcium in the skeleton. The bisphosphonates story illustrates the ills of medicine: Useless and improper treatment, and false interpretation of clinical trials. Bisphosphonates are a class of drugs that prevent the loss of bone density, used to treat osteoporosis and similar diseases Bisphosphonates have become an important treatment for the palliation of metastatic bone disease. Their increasing use has lead to the recognition of toxicities that can lead to substantial morbidity for the patient with advanced cancer. This case presentation highlights toxicities associated with bisphosphonate use and provides some guidelines on the use of bisphosphonates and management of these toxicities. The most important predisposing factors for development of bisphosphonate-associated ONJ are the type and total dose of bisphosphonate (potency) and a history of trauma, dental surgery, or dental infection in the jaw. There is a strong association with jaw trauma such as dental extractions
Просмотров: 316 Gershom Zajicek M.D,
Osteoporosis Drug Brings New Hope To Breast Cancer Treatment
According to findings from the University of Sheffield, using bisphosphonates — drugs for osteoporosis — could also help stop the spread of cancer. Follow : http://www.twitter.com/ See more at http://www.newsy.com Transcript: Findings from researchers at England's University of Sheffield were published Wednesday that could be a serious game changer when it comes to treatment for the spread of breast cancer. Like most cancers, breast cancer has the ability to spread throughout the body, making treatment all the more difficult and slimming chances of survival. One of the places it can spread is to the bones. And that is where this study comes into play — hopefully helping to stop cancer from spreading, especially to bones. According to findings published in the journal Nature, the spread "of breast cancer to the bone affects approximately 85% of patients with advanced disease and renders them largely untreatable." The big takeaway here has to do with an enzyme called lysyl oxidase, or LOX. That enzyme is secreted from cancerous cells in the breasts and can cause the breakdown of bone, making the body more susceptible for cancer to spread. The researchers say the findings add "weight to the growing body of evidence supporting the role of bisphosphonates in stopping secondary breast cancer in its tracks." (Video via The University of Sheffield) Bisphosphonates are a class of drug typically used to treat osteoporosis, or to slow the harsh impact chemotherapy can have on bones. (Video via Rexall) A doctor not affiliated with the University of Sheffield said this: "Certainly a lot of the treatments we use for breast cancer do cause bone loss and the bisphosphonates are used to prevent that or to improve bone density," Dr. Sharon Giordano explained. Using bisphosphonates to not only strengthen bone but also prevent the spread of cancer is a method researchers in the University of Sheffield study found worked in animal tests. According to Katherine Woods, from Breast Cancer Campaign and Breakthrough Breast Cancer, "The reality of living with secondary breast cancer in the bone is a stark one, which leaves many women with bone pain and fractures that need extensive surgery just when they need to be making the most of the time they have left with friends and family." According to Woods, the spread of breast cancer to other areas of the body kills about 1,000 a month in the U.K. **A previous version of this video did not specify that approximately 85 percent of advanced breast cancer patients — not breast cancer patients with all stages of cancer — experience metastasis to the bone."** Sources: Getty Images http://www.gettyimages.com/detail/news-photo/scientist-uses-a-pipette-to-add-a-precise-volume-of-liquid-news-photo/463580696 Healthline http://www.healthline.com/advanced-breast-cancer/anatomy-animations#2/how-and-where-cancer-spreads Wikimedia Commons https://commons.wikimedia.org/wiki/File:Blausen_0686_Osteoporosis_01.png Nature http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14492.html The University of Sheffield http://www.eurekalert.org/pub_releases/2015-05/uos-sik052615.php YouTube https://www.youtube.com/watch?v=99eP4T-8LSE YouTube http://www.youtube.com/watch?v=3CFirK3wfFQ The University of Texas MD Anderson Cancer Center https://www.youtube.com/watch?v=sXqqhGLMiTk National Institutes of Health https://commons.wikimedia.org/wiki/File:003783568lg_Alendronic_acid_35_MG_(as_alendronate_sodium_45.7_MG)_Oral_Tablet.jpg BBC http://www.bbc.com/news/health-32901133 Image via: National Cancer Institute https://visualsonline.cancer.gov/
Просмотров: 1608 Newsy Science
SABCS: More Evidence that Bisphosphonates Prevent Breast Cancer
http://www.medpagetoday.com SAN ANTONIO -- Women taking the osteoporosis drug zoledronic acid had a 30% to 35% lower risk of breast cancer, according to data from two different retrospective studies. Medpage Today: http://medpagetoday.com Online CME - Continuing medical education: http://www.medpagetoday.com/cme/ Latest medical news: http://www.medpagetoday.com/latest/ The MedPage Today app: iOS: https://goo.gl/JKrkHq Android: https://play.google.com/store/apps/details?id=com.medpagetoday.medpage MedPage Today Youtube Channel: https://www.youtube.com/user/MedPageToday Medpage Today on Facebook: https://www.facebook.com/MedPageToday
Просмотров: 116 MedPage Today
Professor Ingunn Holen and research into bisphosphonates for breast cancer
Bisphosphonates are drugs that strengthen bones, and are used to treat osteoporosis, but also to help protect bones when breast cancer spreads to the skeleton – known as secondary breast cancer. Professor Ingunn Holen talks about her research into secondary breast cancer, and how bisphosphonates could be used to treat the disease in the future. Read more about Professor Holen’s research:
Просмотров: 319 Breast Cancer Now
The Dangers of Taking Osteoporosis Drugs
http://www.chiropractor-sacramento.com Osteoporosis drugs can have dangerous side effects, some of which are discussed here.
Просмотров: 2030 CapitolChiropractic
Carpal Tunnel Syndrome | bisphosphonates cause carpal tunnel syndrome
https://www.arthritistreatmentcenter.com Here’s another complication of taking bisphosphonate drugs for osteoporosis… next Do Bisphosphonates Increase Risk of Carpal Tunnel Syndrome? Lara Pullen writing in the Rheumatologist reported increasingly, postmenopausal women are prescribed bisphosphonates in an effort to prevent osteoporotic fractures. The increased prevalence of bisphosphonate use likely reflects both demographic trends toward an older female population, as well as concerns about the safety of an alternative treatment for osteoporosis: hormone replacement therapy. Unfortunately, bisphosphonates are not without risk. In 2008, the FDA issued an alert that highlighted the association between oral bisphosphonates and incapacitating bone, joint and/or musculoskeletal pain. In 2015, the FDA issued yet another alert: warning that the use of bisphosphonates is associated with an increased risk for developing osteonecrosis of the jaw. Researchers have also noted that patients taking bisphosphonates experience an increased risk for arthritis and corresponding arthralgia. Now, investigators report that postmenopausal women who use bisphosphonates are also at increased risk for carpal tunnel syndrome. Comment: what a list of side effects. These drugs might be useful but be careful. https://youtu.be/_s--KEKg_3A
Просмотров: 100 Nathan Wei
FDA Urges Caution Over Long-Term Use of Bone-Density-Building Drugs
Millions of women grapple with whether to take bone-density-building drugs to treat or prevent osteoporosis, but the FDA this week warned that long-term use of bisphosphonates can lead to rare fractures and side effects. Margaret Warner and Maine Medical Center's Dr. Clifford Rosen discuss the risks outlined by the FDA.
Просмотров: 3246 PBS NewsHour
Osteonecrosis of Jaw
Просмотров: 5376 Heath and Beauty
Clodronate Is An Absolute Must for Bone and Breast Cancer Patients - Fitnessential
Clodronate Prevents Breast Cancer : http://www.Fitnessential.co/ Find out more about Clodronate Is An Absolute Must for Bone and Breast Cancer Patients Clodronate Prevents Breast Cancer The treatment of clodronate stops breast cancer from spreading to bone cancer. NOTE: Unavailable in United states. The meals FDA's suppression of clodronate has caused the needless death of around 30, 000 American women every year! Clodronate belongs to a band of drugs which are called bisphosphonates. Bisphosphonates are generally used in treating bone thinning (osteoporosis). In a few situations, they could protect your bones against a number of the ramifications of secondary cancer of the bones, such as for example pain and weakness. Secondary bone cancer occurs if the original (primary) cancer spreads to form a second cancer (metastasis) in the bone. Clodronate is often given alongside other cancer treatments. As well as getting used in some types of secondary bone cancer, it is often been shown to be effective in people who have myeloma (cancer of plasma cells in the blood). Additionally it is used to lower an increasing calcium levels in the blood. Because of secondary cancer of the bone, calcium, which helps fortify the bones, may be lost from the damaged bone and seep to the bloodstream. An increasing amount of calcium in the blood is recognized as hypercalcaemia. This may cause symptoms like for example feeling/being sick (nausea and/or vomiting), tiredness, irritability and even confusion. Clodronate might help reduce high degrees of calcium. Secondary cancer inside the bones may make them weak, and in some situations they might break (fracture). Clodronate might help restrengthen the bones and decrease the risk of fractures. Cancer can impact the bones in different ways, and clodronate isn't helpful for all cancers that affect the bones. Your doctor or specialist nurse can tell you if it would be helpful for you. In normal bone, two types of cells called osteoclasts and osteoblasts come together constantly to shape, rebuild and strengthen existing bone: osteoclasts which destroy old bone and osteoblasts which build new bone. Myeloma and some secondary bone cancers can produce chemicals that produce the osteoclasts work harder. Which means that more bone is destroyed than rebuilt, that leads to weakening of the affected bone. This may hurt and ensures that the bone can fracture or break easier. Clodronate targets areas of bone where the osteoclast activity is high. It helps bring the total amount of osteoclast and osteoblast activity back again to normal by reducing the experience of the osteoclasts. This may reduce pain and help fortify the bone. Additionally, it ensures that less calcium is likely to be lost from the bones. Clodronate is given as a tablet or capsule, frequently taken a couple of times each day. It is recommended that you just take the tablet or capsule in the morning and evening, and not within one or two hours of eating, having a milky drink or taking other medicines. It is because it's harder it to be absorbed to the bloodstream, which can make it much less effective. Avoid using clodronate with mineral supplements, such as for example multi-minerals, for the exact same reason. Read more about this on my blog at: http://www.fitnessential.co/blog/clodronate-stops-breast-cancer-in-its-tracks
Просмотров: 699 TheFitnessential
Why should you NOT use the drugs prescribed for Osteoporosis
http://preventosteoporosis-improveyourbones.com/why-should-you-not-use-the-drugs-prescribed-for-osteoporosis/ Although prescribed to 30 million Americans each year, the bisphosphonate patent medicines (the oral forms, including Fosamax®, Boniva®, Actonel®, and the latest additions to the bisphosphonate arsenal, the once yearly IV-administered patent medicines Reclast® and Aclasta®), are well known to be dangerous. The bisphosphonate patent medicines suppress the activity of osteoclasts, the body's specialized cells whose job it is to remove worn out, injured, or otherwise damaged bone. This is a task that must be taken care of before such weakened bone can be replaced with new strong bone. Moreover, the bisphosphonates don't just inhibit, they virtually crush all new bone formation. In the jaw, bisphosphonates' prevention of normal bone remodeling results in the accumulation of dying bone and its eventual exposure to the inside of the mouth, along with greatly increased risk of oral infection. A number of recent studies, including a meta-analysis of four studies involving more than 26,000 postmenopausal women, have now reported that bisphosphonates increase risk for "serious atrial fibrillation"—that is, an erratic, irregular heartbeat, by more than 150%. In other words, those at risk for serious side effects from bisphosphonates include not only women aged 60 and older who might need dental work, but also anyone with heart disease or diabetes—or more than one-third of the entire US adult population. Numerous other adverse effects have also been reported, including: ■erosions and ulcerations of the esophagus (throat); ■damage to the lining of the gastrointestinal tract; ■esophageal cancer; ■increased risk of stress fractures in bones; ■influenza-like illness; and ■myalgia (severe muscle pain) http://preventosteoporosis-improveyourbones.com/answers/osteoporosis/
Просмотров: 5091 IMPractitioners
Professor Rob Coleman explains landmark bisphosphonates results
Professor Rob Coleman, a leading oncologist and researcher based in Sheffield, explains his landmark results showing that bisphosphonate drugs significantly improve the chances of survival for post-menopausal women diagnosed with breast cancer.
Просмотров: 278 Breast Cancer Now
How Safe are Bisphosphonates?
The bisphosphonates are a well-known family of medications used to cure osteoporosis and atrial fibrillation. The following drugs are all in the bisphosphonate family: Fosamax, Actonel, Boniva, and Reclast. These medications are all very similar with some variations. Recently, these drugs have been reported to have caused severe health problems to its users. FDA is now undergoing thorough evaluation and investigation on these drugs. For more information, visit http:www.hummerlaw.com or you can also call at 1-800-433-8420.
Просмотров: 931 chuckrightontop
What are Bisphosphonates?
Bisphosphonates are a class of drugs that prevent the loss of bone mass, used to treat osteoporosis and similar diseases.
Просмотров: 2674 Health Science Channel
Bisphosphonates linked to increased risk of bone fractures, osteonecrosis of the jaw
Researchers say there are continuing concerns about fracture risk from a group of drugs intended to protect against bone loss.
Просмотров: 42 WPLG Local 10
Which drug is more effective for the treatment of breast cancer: denosumab or bisphosphonates?
Wolfgang Janni, MD, PhD, of the University of Ulm, Ulm, Germany, talks about his side of the debate of whether denosumab or bisphosphonate are more effective drugs for the treatment of breast cancer at the 2016 World Congress on Controversies in Breast Cancer (CoBrCa) in Barcelona, Spain. He explains that his role in the debate is to argue in favor of using denosumab instead of bisphosphonate. He believes that there is very convincing data comparing bisphosphonates and denosumab. Furthermore, the efficacy of denosumab in terms of preventing skeletal-related events, such as pain and also costs associated with with skeletal-related events is much better. He explains that although bisphosphonates have been a lot of help in the past, denosumab is the more effective treatment option now.
Просмотров: 65 VJOncology
What Bone Metastasis Looks Like
be creativo Subscribe today and give the gift of knowledge to yourself or a friend What Bone Metastasis Looks Like 1 : What Is Bone Metastasis? 2 : Risk Factors 3 : Where Bone Metastases Form 4 : Symptoms 5 : Cord Compression 6 : How Metastasis Affects the Bones 7 : Imaging Tests for Bone Metastases 8 : Lab Tests for Bone Metastases 9 : Treating the Primary Cancer 10 : Bisphosphonates 11 : Treating Just the Bones 12 : Surgery 13 : Pain Management 14 : After Treatment
Просмотров: 444 Health & Medication
Use of Osteoporosis Drug May Cause Bone Fractures
Around the world, millions of older women and a smaller number of older men have been taking a drug to prevent hip fractures and fight osteoporosis, a disease caused by low bone mass and bone deterioration. Now some doctors are concerned that patients who have taken the drug, Fosamax, and similar medications for four to five years may be at risk for sudden fractures of the femur, the main thigh bone. VOA's Melinda Smith has details about possible side effects of the drugs, and what the U.S. government's health agency is doing about it.
Просмотров: 3642 VOA News
Advances in prevention and treatment of bone metastases in prostate cancer
Winston Tan, MD of Mayo Clinic, Jacksonville, FL discusses a treatment of bone metastases in prostate cancer. Dr Tan mentions that addition of bisphosphonates does not increase the overall survival of patients suffering from various cancer types, including breast cancer, prostate cancer, and renal cancer. Cabozantinib, approved for metastatic renal cancer makes the bone metastases disappear, however, it has not been shown to increase survival in patients with a metastatic prostate cancer in a phase III randomised clinical trial. A combination of two or three drugs may be required to achieve better results in patients. The next step would be to look at markers, a combination of targets and drugs which can work together to help improve survival and prevent the consequences of bone metastases. Dr Tan highlights the importance of supportive care for cancer patients, who can benefit from an access to physical therapists, psychologists, and nutritionists. This could mean less bone pain and decreased use of pain medication, which may cause dizziness, constipation, or reduced mobility. Ongoing studies in the metastatic prostate cancer compare the micro-environmental factors, before and after the treatment to better understand which genetic and metabolic factors affect the bone metastases. Dr Tan says that prostate cancer patients with bone pain should be offered Radium 223, which improves survival and long-term can improve the symptomatology, and bisphosphonates, or denosumab, which is known to prevent skeletal-related events. Recorded at the Multinational Association of Supportive Care in Cancer (MASCC) and International Society of Ocular Oncology (ISOO) 2016 Annual Meeting on Supportive Care in Cancer held in Adelaide, Australia.
Просмотров: 379 VJOncology
How bisphosphonates interact with your bone crew
Bisphosphonates long term are bone breakers not bone saviours http://www.betterbodychemistry.com/bones/bisphosphonates-bone-crew/ Bisphosphonates are the standard treatment for osteoporosis - initially they make a big difference, improving bone density but the benefit fades with time. Leave your questions or comments below ======================================= **Click below to SUBSCRIBE for More Videos http://www.youtube.com/subscription_center?add_user=spoonfulofscience ======================================= Dr Sandy Evans Scientist turned gremlin buster, helping your create BETTER BODY CHEMISTRY http://www.betterbodychemistry.com Facebook: http://www.facebook.com/betterbodychemistry/ Get the Free WILLPOWER REPORT http://upvir.al/5510/willpower-report
Просмотров: 27616 Better Body Chemistry TV
Hypercalcemia - causes, symptoms, diagnosis, treatment, pathology
What is hypercalcemia? Hypercalcemia's a condition in which there are higher than normal levels of free ionized calcium in the blood. Find more videos at http://osms.it/more. Hundreds of thousands of current & future clinicians learn by Osmosis. We have unparalleled tools and materials to prepare you to succeed in school, on board exams, and as a future clinician. Sign up for a free trial at http://osms.it/more. Subscribe to our Youtube channel at http://osms.it/subscribe. Get early access to our upcoming video releases, practice questions, giveaways, and more when you follow us on social media: Facebook: http://osms.it/facebook Twitter: http://osms.it/twitter Instagram: http://osms.it/instagram Our Vision: Everyone who cares for someone will learn by Osmosis. Our Mission: To empower the world’s clinicians and caregivers with the best learning experience possible. Learn more here: http://osms.it/mission Medical disclaimer: Knowledge Diffusion Inc (DBA Osmosis) does not provide medical advice. Osmosis and the content available on Osmosis's properties (Osmosis.org, YouTube, and other channels) do not provide a diagnosis or other recommendation for treatment and are not a substitute for the professional judgment of a healthcare professional in diagnosis and treatment of any person or animal. The determination of the need for medical services and the types of healthcare to be provided to a patient are decisions that should be made only by a physician or other licensed health care provider. Always seek the advice of a physician or other qualified healthcare provider with any questions you have regarding a medical condition.
Просмотров: 142158 Osmosis
Cancer: RANK Ligand Mechanism of bone metastasis
This video describes the role of the RANK-RANK Ligand system in the process of cancer metastazing to the bone. Cette vidéo décrit le rôle du système RANK-RANK Ligand dans le processus de développement des métastases osseuses. Association website: http://www.efp-online.fr Online education: http://www.invivoveritas.fr
Просмотров: 19219 AssoEFP
FDA warning about severe bone pain and osteoporosis drugs like Fosamax
March 3, 2008 FDA warning about Fosamax and severe bone pain. Is this a precursor to fractures, based on micro-crack formation? For people who want more information or to consult a lawyer about femur and other bone fractures that may have been caused by extended bisphosphonate use: www.my-fosamax-lawsuit.com.
Просмотров: 2374 FosamaxAttorneys
Bisphosphonates and Dentistry: Friend or Foe?
Watch Michael Jackson, DDS as he explains and discusses the important links between Bisphosphonates and dentistry.
Winter Park Family Dental- Fosamax, Boniva, Reclast, Bisphosphonates
Dr Ramzi Matar discusses current medical management of patients taking bisphosphonate medications for treatment of malignant cancers, post menopausal women. How to avoid "BRONJ" or "Jaw Death." You can reach us at www.winterparkfamilydental.com
Osteoporosis | bisphosphonates FDA
http://www.arthritistreatmentcenter.com Should you take bisphosphonates if you have osteoporosis? Maybe yes…maybe no… FDA: More Research Needed To Evaluate Risk, Benefits Of Bisphosphonates. Robert Preidt writing in Healthday reported the FDA has disclosed that more studies are required to determine the “Long-term risks and benefits of taking bisphosphonates, a class of drugs widely used for osteoporosis.” Dr. Marcea Whitaker, “The review’s co-author and a medical officer at the FDA’s Center for Drug Evaluation and Research,” said in a statement, “These drugs clearly work. We just don’t know yet the optimum period of time individual patients should be on the drug to both maximize its effectiveness and minimize potential risks.” The piece noted that bisphosphonates have been used in the U.S. “since 1995 to treat people with osteoporosis.” Comment: No question these drugs are effective. We just need to know more about them. http://youtu.be/Gufxj_Xw2sk
Просмотров: 1789 Nathan Wei
Bisphosphonates: Slide Show of Most Important Points for USMLE
Bisphosphonates rule the kingdom of osteoporosis treatment. Visit www.usmlevideos.net for more videos
Просмотров: 6032 USMLEVideoLectures
Metastatic bone pain
©Geoffrey L. Cheung , M.Sc.Biomedical Communications 2010 Co-supervisors: Linda Wilson-Pauwels, University of Toronto, and Philippe Sarret, Université de Sherbrooke
Dr. Julie Gralow on Treating Breast Cancer Bone Metastases
Julie R. Gralow, MD, Director, Breast Medical Oncology, Seattle Cancer Care Alliance, discusses the recent changes occurring in the anti-osteoclastic targeted therapies used to treat breast cancer bone metastases. The bisphosphonates zoledronic acid (Zometa) and Pamidronate (Aredia) have traditionally been used to treat breast cancer bone metastases. These agents work by blocking the cells that cause bone destruction, which prevents the loss of bone mass. Recently the agent denosumab (Xgeva), a RANK-ligand inhibitor, has become available. In comparison trials, at new diagnosis, between denosumab and bisphosphonates, denosumab proved superior at reducing skeletal-related events and improving other quality of life measures. Gralow advocates for using denosumab in the first-line, when appropriate, or in the second-line after progression on zoledronic acid. Denosumab can be delivered subcutaneously with fewer concerns over serum creatinine levels or first infusion reactions. With the addition of new agents there are now multiple choices for metastatic breast cancer. Trials have now begun to investigate dosing schedules to optimize delivery. The OPTIMIZE-2 trial examined bisphosphonate dosing schedules to determine if they should be given monthly, or every 3 months. Providing therapy every 3 months would reduce many of the adverse events associated with the treatment, such as osteonecrosis of the jaw.
Просмотров: 2997 OncLiveTV
What is PHOSSY JAW? What does PHOSSY JAW mean? PHOSSY JAW meaning, definition & explanation
What is PHOSSY JAW? What does PHOSSY JAW mean? PHOSSY JAW meaning - PHOSSY JAW definition - PHOSSY JAW explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/by-sa/3.0/ license. Phossy jaw, formally phosphorus necrosis of the jaw, is an occupational disease of those who work with white phosphorus, also known as yellow phosphorus, without proper safeguards. It was most commonly seen in workers in the match-stick industry in the 19th and early 20th century. Modern occupational hygiene practices have eliminated the working conditions which caused this disease. Those with phossy jaw would begin suffering painful toothaches and swelling of the gums. Over time, the jaw bone would begin to abscess. Affected bones would glow a greenish-white colour in the dark. The condition also caused serious brain damage. Surgical removal of the afflicted jaw bones could save the patient; otherwise, death from organ failure would follow. The disease was extremely painful and disfiguring to the patient, with dying bone tissue rotting away accompanied by a foul-smelling discharge. However, removal of the jaw bone had serious effects on patients' ability to eat, leading to further health concerns including malnutrition. White phosphorus was the active ingredient of most matches from the 1840s to the 1910s and exposure to the vapour from this caused a deposition of phosphorus in the jaw bones of workers in the industry. Concern over phossy jaw contributed to the London matchgirls strike of 1888, and although this strike did not end the use of white phosphorus, William Booth and The Salvation Army opened a match-making factory in 1891 which used the much safer, though more expensive, red phosphorus. The Salvation Army also campaigned with local retailers to get them to sell only red phosphorus matches. However it was not until the use of white phosphorus was prohibited by the international Berne Convention in 1906, and these provisions were implemented in national laws over the next few years, that industrial use ceased. A related condition, bisphosphonate-associated osteonecrosis of the jaw (BON), has been described as a side-effect of amino-bisphosphonates, a class of phosphorus-based drugs that inhibit bone resorption and are used widely for treating osteoporosis, bone disease in cancer and some other conditions. BON, sometimes called "bis-phossy jaw", is primarily associated with the use of intravenous bisphosphonates in the treatment of cancer. The percentage incidence of BON from this use is approximately 1000 times higher than the incidence of BON caused by the use of oral bisphosphonates.
Просмотров: 1018 The Audiopedia
Attorney for necrosis jawbone death Fosamax & Boniva
Story about General Hospital's Sharon Wyatt whom has to undergo major jawbone surgery for Jawbone necrosis, caused by use of bisphosphonates. Sharon had to have part of her dead jawbone cut out and removed. In it's place is a titanium plate, screwed into the surrounding jawbone. If you or a loved one has suffered serious side effects from taking Fosamax or Boniva, please call our office today at 727-397-9198 for a free consultation or visit us at http://www.hummerlaw.com
Просмотров: 321 hummerlaw
Boniva A  Bisphosphonate- Osteoporsis Medication-Watch The Side Effects
Please visit us http://defectivedrugsettlements.com/bone-density-drug-submission Patients have relied on this medication to help prevent osteoporosis, pagets disease and various other conditions for many years. Many doctors have turned to the bisphosphonates family of drugs to maintain bone strength in women,treat pagets disease and help in the aid to some cancer victims. But some users are experiencing serious side effects, including weak and brittle bones, loew energy femur fractures and something called dead jaw disease . If you have been affected , our attorneys are offering a free no-obligation consultation to discuss your legal options.
Просмотров: 899 Robert Martin
Potential Risks of Osteoporosis Medications
MedStar NRH's Dr. Robert Bunning has conducted extensive research on how osteoporosis medications called bisphosphonates may cause sudden bone breaks and fractures. He provides insight on the subject in this piece that originally aired on Channel 4 News (NBC4) in Washington, DC. Learn more about Orthopaedic Injuries and Post-Surgical Services: http://ow.ly/OWe1i Learn more about Dr. Bunning: http://ow.ly/OWelL
Просмотров: 552 MedStar National Rehabilitation Network
Attorney for femur bone fractures from bisphosphonates Fosamax Boniva
Diane Sawyer interviews Dr. Richart Besser regarding the skyrocketing use of the Biophosphonate called Fosamax made by Merch. Taken long-term, Bisphosphonates can cause bones to become weak, brittle and even shear. Many women have reported breaks in their thigh bones. If you or a loved one has suffered serious side effects from taking Fosamax or Boniva, please call our office today at 727-397-9198 for a free consultation or visit us at http://www.hummerlaw.com
Просмотров: 214 hummerlaw
Risk Factors And Medications For Osteoporosis - Manipal Hospitals
Osteoporosis is a condition where bones weaken and tend to break faster. People having osteoporosis have abnormally finned bones with larger holes in spongy bones. There are two types of osteoporosis know as primary osteoporosis, which is seen in old people and women, and Secondary osteoporosis, seen in both children and adults. It is also related to hormonal problems, certain medications and cancer. It occurs after the age of thirty. This video is an informative animated presentation that explains in detail about Osteoporosis. Bones contain cells called osteoclasts that breakdown bone tissue. Other cells called osteoblasts make new bone tissue using minerals such as calcium and phosphate from the blood. Hormones such as estrogen, growth hormones and testosterone help keep the number and activity of osteoblasts higher than osteoclast, so that more bone is made than removed. Osteoporosis is a condition that leads to weaken bones, causing them to break more easily. Healthy bone is dense enough to support and protect the body, and to handle the stresses of movement & minor injuries. However, people with osteoporosis have abnormally thin bones with larger holes in the spongy bone. There are two types of osteoporosis; primary osteoporosis is usually related to older age, secondary osteoporosis affects both children and adults. A person has a greater risk for either type of osteoporosis, if they don’t develop enough bone mass when they are growing from childhood to adulthood. Watch the video to know more in detail about Osteoporosis. Best Hospital in India: Manipal Hospitals is one of the top multi-specialty hospital in India located at all major cities like Bangalore, Vijayawada, Visakhapatnam, Goa, Salem, Jaipur, Mangalore. Provides world class 24/7 Emergency services. Our top surgeons are expertise in offering best treatment for Heart, Brain, Cancer, Eye, Kidney, Joint replacement surgery & all major surgeries at affordable cost. Health Check-up packages are also available. To know more visit our website : https://www.manipalhospitals.com/ Get Connected Here: ================== Facebook: https://www.facebook.com/ManipalHospitalsIndia Google+: https://plus.google.com/111550660990613118698 Twitter: https://twitter.com/ManipalHealth Pinterest: https://in.pinterest.com/manipalhospital Linkedin: https://www.linkedin.com/company/manipal-hospital Instagram: https://www.instagram.com/manipalhospitals/ Foursquare: https://foursquare.com/manipalhealth Alexa: http://www.alexa.com/siteinfo/manipalhospitals.com Blog: https://www.manipalhospitals.com/blog/
Просмотров: 2186 Manipal Hospitals
Fosamax Drug Injury Lawyer
Fosamax is part of a class of drugs known as bisphosphonates, which are used to treat osteoporosis and bone pain caused by some types of cancer. Fosamax is the most commonly dispensed bisphosphonate in the United States and accounted for 22 million prescriptions by 2004 (2). Bisphosphonates are often used in the management of certain cancers—such as lung, breast, prostate, and multiple myeloma—where cancer has metastasized (spread) to the bone.
Просмотров: 1813 DrugLawyers
Bisphosphonates: Safety and Effectiveness for Osteoporosis Treatment - Susan Ott, M.D.
Watch the full video online at http://onlinesymposia.com/online-videos/27-ccr2012
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Cancer and Its Effects On Bones
Encouraging news to help cancer patients manage their bone health New Data Presented at the Annual San Antonio Breast Cancer Symposium Adam Brufsky, MD, one of the nations leading breast cancer oncologists and researchers. -Assistant Professor of Medicine, Associate Division Chief for the Division of Hematology/Oncology, University of Pittsburgh School of Medicine -Co-Director, Comprehensive Breast Cancer Center; Medical Director, Women's Cancer Center at Magee Womens Hospital/UPCI, Pittsburgh, PA Even following treatment, people diagnosed with cancer still face the risk that their cancer may spread, or metastasize, to another part of their body, most commonly their bones. These bone metastases break down the bone, often leading to painful complications that can affect patients quality of life. In addition, certain cancer therapies can also affect the integrity of the bones. Treatments such as aromatase inhibitors, a class of drugs used to help treat breast cancer patients can sometimes also lead to bone loss. Results from data presented at the recent San Antonio Breast Cancer Symposium demonstrates the advantages of treatment with bisphosphonates, which are used to treat bone complications associated with cancer, in helping to improve and maintain bone health. Data showed that the use of bisphosphonates taken in conjunction with an aromatase inhibitor following surgery may significantly reduce the risk of fracture. Physician Biography: Dr. Adam Brufsky Medical Oncology Adam M. Brufsky, MD, PhD, is currently Assistant Professor of Medicine at the University of Pittsburgh School of Medicine. He serves as Co-Director, Comprehensive Breast Cancer Center and Medical Director, Women's Cancer Center at the Magee Womens Hospital/UPCI, Pittsburgh, PA. He also serves as the Associate Division Chief for the Division of Hematology/Oncology within the University of Pittsburgh School of Medicine's Department of Medicine. He earned his MD and his PhD from the University of Connecticut School of Medicine in Farmington, CT, completed a residency at Brigham and Women's Hospital, Harvard Medical School, and a Fellowship at Dana-Farber Cancer Institute. Dr. Brufsky is board certified in Internal Medicine and Medical Oncology by the American Board of Internal Medicine. An active researcher, he has numerous abstracts and research articles in leading journals, and is Principal Investigator on a number of research grants funded by the National Institutes of Health, Susan G. Komen Foundation, and US Army Breast Cancer Research Program.
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Dr. Robert Bunning on the Rare Side Effects of Bisphosphonates
The FDA recently launched new hearings on the safety of bisphosphonates -- medications commonly used to treat osteoporosis. MedStar NRH physician Dr. Robert Bunning participated in those hearings and spoke to WUSA'-TV CBS 9 News in Washington, DC about his testimony and the latest from those hearings. Learn more about our hospital: http://ow.ly/MsNQe Learn more about Dr. Bunning: http://ow.ly/MsNKm Aired September 12, 2011.
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Bone Booster May Cut Cancer Risk
http://www.dailyrx.com/bisphosphonates-may-reduce-endometrial-cancer-risk-women A new study found that women who had taken bisphosphonates had a reduced rate of endometrial cancer.
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Treating Bone Mass Loss in Prostate Cancer Patients
Androgen-Deprivation treatment can increase a man's risk for developing bone loss. Several hormones protect bones from losing density and testosterone is one of theses. Androgen-Deprivation treatment causes testosterone levels to go down and bone loss starts to occur at an increasing rate. There are some medications you can use to help maintain your bone mass. Certified Physicians Assistant Jennifer Wilson discusses what these medications are and how they work in this video. VIEW THE ARTICLE: How to Increase Bone Mass in Patients with Prostate Cancer - http://www.prostatecancerlive.com/?p=13723 SUBSCRIBE FOR MORE EXPERT INFORMATION AND BREAKING PROSTATE CANCER NEWS http://youtube.com/subscription_cente... VISIT PROSTATECANCERLIVE.com FOR TONS OF INFORMATIVE VIDEOS http://www.prostatecancerlive.com/# SUGGEST THE NEXT TOPIC FOR OUR PROSTATE CANCER EXPERTS! http://www.prostatecancerlive.com/# CONNECT WITH US! Google+: http://bit.ly/17F4WQr Facebook: https://www.facebook.com/pages/ProstateCancerLive Twitter: https://twitter.com/ProstateLive
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Prostate Cancer: Diet
read more on the link : Researchers from Canada have found that having a diet of red meat, organ meats, soft drink and bottled water increased the risk of getting prostate cancer. They compared the diets of 80 men with prostate cancer, and 334 healthy men, and the diet just described more than doubled the risk of developing prostate cancer. So what prostate diet can reduce the risk of prostate cancer? Swedish researchers examined the diet of 1499 men with prostate cancer and 1130 men who were healthy, and they published their findings in the Cancer Causes and Control journal. They found that eating foods rich in phytoestrogens decreased the risk of prostate cancer. Phytoestrogens are plant molecules that have a weak estrogenic effect. They are made converted in the intestines from plant precursors by bacteria as they digest food. They are taken up by the same parts of the body that process the hormone estrogen. Interestingly, one of the treatments for prostate cancer by doctors involves using estrogens to reduce the level of testosterone in men with advanced prostate cancer. It does this indirectly, through its effect on the hypothalamus, as less luteinizing hormone releasing hormone is produced by the hypothalamus. This means not as much luteinizing hormone is released by the body, which suppresses the production of testosterone. High doses of estrogens for men can lead to cardiovascular complications. But phytoestrogens obtained from diet, in less quantities than a drug, and with a milder effect to start with, should not pose a problem. And researchers don't yet know what exactly causes phytoestrogens to have such a protective effect, whether it is similar to that of the estrogen treatment for advanced prostate cancers. And they don't know which phytoestrogens are the most active. So what phytoestrogen foods could you include in a diet for a healthy prostate? Soy beans and nuts are a good source. Soy and nuts contain a type of phytoestrogen called isoflavones, whilst berries and seeds contain lignans. Foods could include peanuts, sunflower seeds, peanuts, and berries. The only possible concerns with soy is that a study in mice found that male mice that had a type of heart disease that people also have, suffered heart failure when fed a soy based diet. Whether this extrapolates to the human population is yet to be established. But it may be wise for those me who have this particular genetic heart condition, dilated cardiomyopathy, to be cautious about soy products in their diet. But for other men, soy products could be good news. A meta analysis, which is a study of related studies, published in the International Journal of Cancer, found that diets high in soy lowered men's risk of prostate cancer by 30%. Another important mineral to consider for men is zinc. Zinc is used by men's bodies to make some of the male hormones, and for general prostate health. A deficiency in zinc can lead to problems with the testicles, the prostate, and the health of the sperm. Foods that are great sources of zinc include seeds like pumpkin, sesame, and sunflower; nuts like almonds, brazil, cashews and walnuts; and foods like lettuce, oats and onions. Raw onion is particularly suggested by Paul Bedson, a natural therapist. He also suggests vegetable juice made of equal parts of beetroot, carrot, and cucumber in cases where the prostate gland is enlarged. Cranberry juice, a cup drunk three times a day, is also recommended in this case. prostate, prostrate, cancer, prostate cancer, diagnosing prostate cancer, symptoms of prostate cancer, information on prostate cancer, prostate cancer treatment, mens cancer, men's cancer, PSA, psa, therapy, hormone, symptoms, prostatectomy, brachytherapy, cryosurgery, metastatic, 3D conformal, information, diet, research, radiation, radiotherapy, prevention, screening, localised, support, surgery, awareness, treatment, advanced, donation, symptom, bracytherapy, prostatic, gleason, tookit, Tool Kit, gleason score, biopsy, psa test, prostate gland, prostate specific antigen, HIFU, hifu, bisphosphonates, cryotherapy, health professionals, charity, men, campaigning, fundraising, gland, helpline, prostate cancer publications, prostate cancer booklets, diagnosed, palliative radiotherapy, chemotherapy, continence, events, fundraise, campaign, specialist nurses, african caribbean, prostate cancer charity, prostate cancer symptoms, trus, prostate problems, prostate cancer awareness month, prostate biopsy, gleason grading, DRE, BPH, prostatitis, localised prostate cancer, locally advanced prostate cancer, advanced prostate cancer, active surveillance, hormone therapy, high dose rate brachytherapy, bisphosphonates, palliative radiotherapy, clinical trials, HIFU,Prostate cancer, PSA,prostate cancer, oncology, medical animation, health app, educational, prostate cancer animated video, prostate cancer information, prostate cancer video
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Gold Nanoparticles in Treatment of Prostate Cancer
Current treatment for prostate cancer is expensive, has numerous side-effects, and has a high mortality rate. It is astonishing how long this ailment has affected humanity without providing a reliable solution. Consequently, our team will examine how gold charged nanoparticles are used to aid the treatment of prostate cancer, specifically via drug delivery. These particles have a gold inner core and are coated with polyethylene glycol. Polyethylene glycol and gold are used due to their relatively inert state and non-toxicity. Gold is also used because, at a nanoscale, it is a catalyst for reactions. The surface chemistry of gold nanoparticles can be altered so that they can be coated with small polymers and other therapeutic agents such as cancer-treating drugs (specifically Docetaxel and Doxorubicin). This also gives the patient's DNA the ability to bond to the nanoparticle’s surface, which allows these nanoparticles to travel through the body without being rejected. These nanoparticles are spherical shaped, and while studies are beginning to show that non-spherical particles are more effective than spherical particles, researchers do not yet fully understand the shape effect non-spherical particles have on cancerous cells. The diameter of these nanoparticles is less than 170nm so that they can effectively fit through and diffuse inside cells and capillaries. Additionally, these nanoparticles are charged. Due to their charge, the nanoparticles repel each other, which prevents them from aggregating. Furthermore, it simply helps nanoparticles interact with cells and diffuse through concentration barriers more efficiently. This method of prostate cancer treatment is still being researched and has yet to be approved for medical use; however, it has the potential to replace current treatment methods, as it could be more effective and safer in practice. Works Cited "Docetaxel May Cause Alcohol Intoxication: FDA." Headlines, Today's News Headlines, Current Breaking News. N.p., n.d. Web. 01 May 2017. "Doctors: Chemotherapy Expensive and Does Little for Advanced Cancer Patients." Infowars. N.p., 15 Nov. 2016. Web. 01 May 2017. "Doxorubicin HCL Vial : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing." WebMD. WebMD, n.d. Web. 01 May 2017. FGRGAnimation. "Nanotechnology for Targeted Cancer Therapy." YouTube. YouTube, 15 Jan. 2010. Web. 08 May 2017. "Gold Nanoparticles in Delivery Applications ☆." Gold Nanoparticles in Delivery Applications. N.p., n.d. Web. 1 May 2017. "Gold Nanoparticles: Properties and Applications." Sigma-Aldrich. N.p., n.d. Web. 1 May 2017. Herizchi, Roya. "Current Methods for Synthesis of Nanoparticles." Https://www.researchgate.net/publication/267755166_Current_methods_for_synthesis_of_gold_nanoparticles. N.p., n.d. Web. 02 May 2017. Llevot, Audrey, and Didier Astruc. "Applications of Vectorized Gold Nanoparticles to the Diagnosis and Therapy of Cancer." Chemical Society Reviews. The Royal Society of "Prostate Cancer." Mayo Clinic. Mayo Foundation for Medical Education and Research, n.d. Web. 06 May 2017. "Prostate Cancer: Statistics That May Surprise You." Cancer. N.p., 18 Nov. 2015. Web. 01 May 2017. "Radiation Therapy for Prostate Cancer | CTCA." CancerCenter.com. N.p., 01 Jan. 0001. Web. 01 May 2017. SanofiTVen. “Cancer: From A Healthy Cell to a Cancer Cell.” YouTube. YouTube, 25 Jan. 2011. Web. 08 May 2017. Shah, Samar, Yaling Liu, Walter Hu, and Jinming Gao. "Modeling Particle Shape-Dependent Dynamics in Nanomedicine." Journal of Nanoscience and Nanotechnology. U.S. National Library of Medicine, Feb. 2011. Web. 01 May 2017. Yuriy Svidinenko. “Nanoparticle Drug Delivery in Cancer Therapy.” YouTube. YouTube, 3 Mar. 2013. Web. 08 May 2017.
Managing Bone Metastases in Prostate Cancer
Drs Philippa Cheetham and Glen Gejerman remark on the use of bone-targeted radiopharmaceuticals in relieving side effects of bone metastases in prostate cancer. View more at http://curetoday.com/ CURE: Combining science and humanity to make cancer understandable.
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Medication related osteonecrosis of the jaw
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New study on osteoporosis drugs, breast cancer
The most-widely used osteoporosis drugs may not protect women from breast cancer after all. Also, a new look at the science of sleep medication shows there may be little evidence the drugs provide much benefits. Wendy Gillette reports on the day's top medical headlines.
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prostate cancer
Prostate cancer is the development of cancer in the prostate, a gland in the male reproductive system.[6] Most prostate cancers are slow growing; however, some grow relatively quickly.[1][3] The cancer cells may spread from the prostate to other parts of the body, particularly the bones and lymph nodes.[7] It may initially cause no symptoms.[1] In later stages it can lead to difficulty urinating, blood in the urine, or pain in the pelvis, back or when urinating.[2] A disease known as benign prostatic hyperplasia may produce similar symptoms.[1] Other late symptoms may include feeling tired due to low levels of red blood cells.[1] Factors that increase the risk of prostate cancer include: older age, a family history of the disease, and race.[3] About 99% of cases occur in those over the age of 50.[3] Having a first-degree relative with the disease increases the risk two to threefold.[3] In the United States, it is more common in the African American population than the white American population.[3] Other factors that may be involved include a diet high in processed meat, red meat, or milk products or low in certain vegetables.[3] An association with gonorrhea has been found, but a reason for this relationship has not been identified.[8] Prostate cancer is diagnosed by biopsy.[2] Medical imaging may then be done to determine if the cancer has spread to other parts of the body.[2] Prostate cancer screening is controversial.[1][3] Prostate-specific antigen (PSA) testing increases cancer detection but does not decrease mortality.[9] The United States Preventive Services Task Force recommends against screening using the PSA test, due to the risk of overdiagnosis and overtreatment, as most cancer diagnosed would remain asymptomatic.[10] The USPSTF concludes that the potential benefits of testing do not outweigh the expected harms.[10] While 5α-reductase inhibitors appear to decrease low-grade cancer risk they do not affect high-grade cancer risk and thus are not recommended for prevention.[3] Supplementation with vitamins or minerals does not appear to affect the risk.[3][11] Many cases can be safely followed with active surveillance or watchful waiting.[2] Other treatments may include a combination of surgery, radiation therapy, hormone therapy or chemotherapy.[2] When it only occurs inside the prostate it may be curable.[1] In those in whom the disease has spread to the bones, pain medications, bisphosphonates and targeted therapy, among others, may be useful.[2] Outcomes depend on a person's age and other health problems as well as how aggressive and extensive the cancer is.[2] Most people with prostate cancer do not end up dying from the disease.[2] The 5-year survival rate in the United States is 99%.[4] Globally it is the second most common type of cancer and the fifth leading cause of cancer-related death in men.[5] In 2012 it occurred in 1.1 million men and caused 307,000 deaths.[5] It was the most common cancer in males in 84 countries,[3] occurring more commonly in the developed world.[12] Rates have been increasing in the developing world.[12] Detection increased significantly in the 1980s and 1990s in many areas due to increased PSA testing.[3] Studies of males who died from unrelated causes have found prostate cancer in 30% to 70% of those over age 60.[
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