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Bisphosphonates and Cancer
http://www.melioguide.com/free-course Mary-Ann Dalzell, an oncology clinical specialist, discusses the role of bisphosphonates in treating cancer.
Просмотров: 447 Margaret Martin
Say No to Bisphosphonates
Say No to Bisphosphonates Bisphosphonates cause a systemic subclinical toxicity which may erupt as osteonecrosis. Bisphosphonates are structural analogues to calcium pyrophosphate in bone and bind to calcium in the skeleton. The bisphosphonates story illustrates the ills of medicine: Useless and improper treatment, and false interpretation of clinical trials. Bisphosphonates are a class of drugs that prevent the loss of bone density, used to treat osteoporosis and similar diseases Bisphosphonates have become an important treatment for the palliation of metastatic bone disease. Their increasing use has lead to the recognition of toxicities that can lead to substantial morbidity for the patient with advanced cancer. This case presentation highlights toxicities associated with bisphosphonate use and provides some guidelines on the use of bisphosphonates and management of these toxicities. The most important predisposing factors for development of bisphosphonate-associated ONJ are the type and total dose of bisphosphonate (potency) and a history of trauma, dental surgery, or dental infection in the jaw. There is a strong association with jaw trauma such as dental extractions
Просмотров: 393 Gershom Zajicek M.D,
Osteoporosis Drug Brings New Hope To Breast Cancer Treatment
According to findings from the University of Sheffield, using bisphosphonates — drugs for osteoporosis — could also help stop the spread of cancer. Follow : http://www.twitter.com/ See more at http://www.newsy.com Transcript: Findings from researchers at England's University of Sheffield were published Wednesday that could be a serious game changer when it comes to treatment for the spread of breast cancer. Like most cancers, breast cancer has the ability to spread throughout the body, making treatment all the more difficult and slimming chances of survival. One of the places it can spread is to the bones. And that is where this study comes into play — hopefully helping to stop cancer from spreading, especially to bones. According to findings published in the journal Nature, the spread "of breast cancer to the bone affects approximately 85% of patients with advanced disease and renders them largely untreatable." The big takeaway here has to do with an enzyme called lysyl oxidase, or LOX. That enzyme is secreted from cancerous cells in the breasts and can cause the breakdown of bone, making the body more susceptible for cancer to spread. The researchers say the findings add "weight to the growing body of evidence supporting the role of bisphosphonates in stopping secondary breast cancer in its tracks." (Video via The University of Sheffield) Bisphosphonates are a class of drug typically used to treat osteoporosis, or to slow the harsh impact chemotherapy can have on bones. (Video via Rexall) A doctor not affiliated with the University of Sheffield said this: "Certainly a lot of the treatments we use for breast cancer do cause bone loss and the bisphosphonates are used to prevent that or to improve bone density," Dr. Sharon Giordano explained. Using bisphosphonates to not only strengthen bone but also prevent the spread of cancer is a method researchers in the University of Sheffield study found worked in animal tests. According to Katherine Woods, from Breast Cancer Campaign and Breakthrough Breast Cancer, "The reality of living with secondary breast cancer in the bone is a stark one, which leaves many women with bone pain and fractures that need extensive surgery just when they need to be making the most of the time they have left with friends and family." According to Woods, the spread of breast cancer to other areas of the body kills about 1,000 a month in the U.K. **A previous version of this video did not specify that approximately 85 percent of advanced breast cancer patients — not breast cancer patients with all stages of cancer — experience metastasis to the bone."** Sources: Getty Images http://www.gettyimages.com/detail/news-photo/scientist-uses-a-pipette-to-add-a-precise-volume-of-liquid-news-photo/463580696 Healthline http://www.healthline.com/advanced-breast-cancer/anatomy-animations#2/how-and-where-cancer-spreads Wikimedia Commons https://commons.wikimedia.org/wiki/File:Blausen_0686_Osteoporosis_01.png Nature http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14492.html The University of Sheffield http://www.eurekalert.org/pub_releases/2015-05/uos-sik052615.php YouTube https://www.youtube.com/watch?v=99eP4T-8LSE YouTube http://www.youtube.com/watch?v=3CFirK3wfFQ The University of Texas MD Anderson Cancer Center https://www.youtube.com/watch?v=sXqqhGLMiTk National Institutes of Health https://commons.wikimedia.org/wiki/File:003783568lg_Alendronic_acid_35_MG_(as_alendronate_sodium_45.7_MG)_Oral_Tablet.jpg BBC http://www.bbc.com/news/health-32901133 Image via: National Cancer Institute https://visualsonline.cancer.gov/
Просмотров: 1614 Newsy Science
Bisphosphonate Use in Breast Cancer
In this segment, Sara Hurvitz, MD; Hope Rugo, MD; Dialecti Voudouris, MD; and Eleftherios Mamounas, MD, examine the use of bisphosphonates in breast cancer.
Просмотров: 449 OncLiveTV
How bisphosphonates interact with your bone crew
Bisphosphonates long term are bone breakers not bone saviours http://www.betterbodychemistry.com/bones/bisphosphonates-bone-crew/ Bisphosphonates are the standard treatment for osteoporosis - initially they make a big difference, improving bone density but the benefit fades with time. Leave your questions or comments below ======================================= **Click below to SUBSCRIBE for More Videos http://www.youtube.com/subscription_center?add_user=spoonfulofscience ======================================= Dr Sandy Evans Scientist turned gremlin buster, helping your create BETTER BODY CHEMISTRY http://www.betterbodychemistry.com Facebook: http://www.facebook.com/betterbodychemistry/ Get the Free WILLPOWER REPORT http://upvir.al/5510/willpower-report
Просмотров: 28736 Better Body Chemistry TV
What are Bisphosphonates?
Bisphosphonates are a class of drugs that prevent the loss of bone mass, used to treat osteoporosis and similar diseases.
Просмотров: 2759 Health Science Channel
Bone metastases: Role of zoledronic acid, denosumab and other strategies
In this presentation from the 21st Annual Perspectives in Thoracic Oncology, Dr. Vera Hirsh discusses the role of zoledronic acid, denosumab, and other strategies in the treatment of bone metastases. Earn CME credit for a related activity at the following location: http://elc.imedex.com/ELC/Specialty-Search.aspx?search=7228 © 2016 Imedex, LLC.
Просмотров: 2780 ImedexCME
Carpal Tunnel Syndrome | bisphosphonates cause carpal tunnel syndrome
https://www.arthritistreatmentcenter.com Here’s another complication of taking bisphosphonate drugs for osteoporosis… next Do Bisphosphonates Increase Risk of Carpal Tunnel Syndrome? Lara Pullen writing in the Rheumatologist reported increasingly, postmenopausal women are prescribed bisphosphonates in an effort to prevent osteoporotic fractures. The increased prevalence of bisphosphonate use likely reflects both demographic trends toward an older female population, as well as concerns about the safety of an alternative treatment for osteoporosis: hormone replacement therapy. Unfortunately, bisphosphonates are not without risk. In 2008, the FDA issued an alert that highlighted the association between oral bisphosphonates and incapacitating bone, joint and/or musculoskeletal pain. In 2015, the FDA issued yet another alert: warning that the use of bisphosphonates is associated with an increased risk for developing osteonecrosis of the jaw. Researchers have also noted that patients taking bisphosphonates experience an increased risk for arthritis and corresponding arthralgia. Now, investigators report that postmenopausal women who use bisphosphonates are also at increased risk for carpal tunnel syndrome. Comment: what a list of side effects. These drugs might be useful but be careful. https://youtu.be/_s--KEKg_3A
Просмотров: 100 Nathan Wei
Dr. Robert Bunning on the Rare Side Effects of Bisphosphonates
The FDA recently launched new hearings on the safety of bisphosphonates -- medications commonly used to treat osteoporosis. MedStar NRH physician Dr. Robert Bunning participated in those hearings and spoke to WUSA'-TV CBS 9 News in Washington, DC about his testimony and the latest from those hearings. Learn more about our hospital: http://ow.ly/MsNQe Learn more about Dr. Bunning: http://ow.ly/MsNKm Aired September 12, 2011.
Просмотров: 519 MedStar National Rehabilitation Network
Attorney for necrosis jawbone death Fosamax & Boniva
Story about General Hospital's Sharon Wyatt whom has to undergo major jawbone surgery for Jawbone necrosis, caused by use of bisphosphonates. Sharon had to have part of her dead jawbone cut out and removed. In it's place is a titanium plate, screwed into the surrounding jawbone. If you or a loved one has suffered serious side effects from taking Fosamax or Boniva, please call our office today at 727-397-9198 for a free consultation or visit us at http://www.hummerlaw.com
Просмотров: 383 hummerlaw
The Dangers of Taking Osteoporosis Drugs
http://www.chiropractor-sacramento.com Osteoporosis drugs can have dangerous side effects, some of which are discussed here.
Просмотров: 2082 CapitolChiropractic
FDA warning about severe bone pain and osteoporosis drugs like Fosamax
March 3, 2008 FDA warning about Fosamax and severe bone pain. Is this a precursor to fractures, based on micro-crack formation? For people who want more information or to consult a lawyer about femur and other bone fractures that may have been caused by extended bisphosphonate use: www.my-fosamax-lawsuit.com.
Просмотров: 2460 FosamaxAttorneys
SABCS: More Evidence that Bisphosphonates Prevent Breast Cancer
http://www.medpagetoday.com SAN ANTONIO -- Women taking the osteoporosis drug zoledronic acid had a 30% to 35% lower risk of breast cancer, according to data from two different retrospective studies. Medpage Today: http://medpagetoday.com Online CME - Continuing medical education: http://www.medpagetoday.com/cme/ Latest medical news: http://www.medpagetoday.com/latest/ The MedPage Today app: iOS: https://goo.gl/JKrkHq Android: https://play.google.com/store/apps/details?id=com.medpagetoday.medpage MedPage Today Youtube Channel: https://www.youtube.com/user/MedPageToday Medpage Today on Facebook: https://www.facebook.com/MedPageToday
Просмотров: 116 MedPage Today
Why should you NOT use the drugs prescribed for Osteoporosis
http://preventosteoporosis-improveyourbones.com/why-should-you-not-use-the-drugs-prescribed-for-osteoporosis/ Although prescribed to 30 million Americans each year, the bisphosphonate patent medicines (the oral forms, including Fosamax®, Boniva®, Actonel®, and the latest additions to the bisphosphonate arsenal, the once yearly IV-administered patent medicines Reclast® and Aclasta®), are well known to be dangerous. The bisphosphonate patent medicines suppress the activity of osteoclasts, the body's specialized cells whose job it is to remove worn out, injured, or otherwise damaged bone. This is a task that must be taken care of before such weakened bone can be replaced with new strong bone. Moreover, the bisphosphonates don't just inhibit, they virtually crush all new bone formation. In the jaw, bisphosphonates' prevention of normal bone remodeling results in the accumulation of dying bone and its eventual exposure to the inside of the mouth, along with greatly increased risk of oral infection. A number of recent studies, including a meta-analysis of four studies involving more than 26,000 postmenopausal women, have now reported that bisphosphonates increase risk for "serious atrial fibrillation"—that is, an erratic, irregular heartbeat, by more than 150%. In other words, those at risk for serious side effects from bisphosphonates include not only women aged 60 and older who might need dental work, but also anyone with heart disease or diabetes—or more than one-third of the entire US adult population. Numerous other adverse effects have also been reported, including: ■erosions and ulcerations of the esophagus (throat); ■damage to the lining of the gastrointestinal tract; ■esophageal cancer; ■increased risk of stress fractures in bones; ■influenza-like illness; and ■myalgia (severe muscle pain) http://preventosteoporosis-improveyourbones.com/answers/osteoporosis/
Просмотров: 5393 IMPractitioners
Which drug is more effective for the treatment of breast cancer: denosumab or bisphosphonates?
Wolfgang Janni, MD, PhD, of the University of Ulm, Ulm, Germany, talks about his side of the debate of whether denosumab or bisphosphonate are more effective drugs for the treatment of breast cancer at the 2016 World Congress on Controversies in Breast Cancer (CoBrCa) in Barcelona, Spain. He explains that his role in the debate is to argue in favor of using denosumab instead of bisphosphonate. He believes that there is very convincing data comparing bisphosphonates and denosumab. Furthermore, the efficacy of denosumab in terms of preventing skeletal-related events, such as pain and also costs associated with with skeletal-related events is much better. He explains that although bisphosphonates have been a lot of help in the past, denosumab is the more effective treatment option now.
Просмотров: 68 VJOncology
Multiple Myeloma - Everything You Need To Know - Dr. Nabil Ebraheim
Dr. Ebraheim’s educational animated video describes multiple myeloma. Multiple myeloma is cancer of the plasma cells. It is malignant proliferation of the plasma cells. Plasma cells are a type of blood cells that produce antibodies. Antibodies are an important part of the immune system that fights infection. Multiple myeloma cells produce a single protein – Monoclonal protein, M protein. Multiple myeloma occurs more often in males and twice as often in African Americans. It usually occurs in patients older than 40 years of age. Multiple myeloma is the most common primary malignant bone tumor. The plasma cells secrete osteoclast activating factors such as interleukin 6, macrophages and inflammatory factors in addition to RANKL. Osteoclasts are recruited, activated and they multiple. Osteoclasts absorb the bone. The osteoblast bone formation is suppressed by the tumor necrosis factor (why there is a cold bone scan in multiple myeloma). In about 30%, the bone scan is negative. Get a skeletal survey. Clinical features: Useful mnemonic to help remember the most common features of multiple myeloma is CRAP, which stands for hypercalcemia, Renal failure, Anemia, and back Pain. Clinical features will be insidious presentation. Bone pain, especially back pain with possible fractures, weakness and fatigue, cord compression, infections and fever. Multiple myeloma can occur in any bone although it occurs more in the hematopoietic bone marrow! Labs: Sedimentation rate may be elevated. May find renal insufficiency, hypercalcemia, and anemia. Electrophoresis will find a spike in the serum, in the urine, or in both. Serum Protein ElectroPhoresis (SPEP) detects monoclonal elevation of the immunoglobulin and identifies the protein types that are present. Urine Protein ElectroPhoresis (UPEP) – bence jones proteinuria (urine) and light chains (about 95% sensitivity). What are the tumor markers that indicate a bad prognosis? Increased serum beta1-microglobulin level and a decreased serum albumin. How do you establish the diagnosis? One major and one minor criteria is needed or three minor criterion. What are the major criteria? The major criteria are plasmacytoma tissue diagnosis on biopsy, more than 30% plasma cells in the bone marrow, SPEP with great value for IgG or IgA and/or UPEP (Bence Jones Proteinuria). The minor criteria are 10% - 30% plasma cells in the bone marrow, monoclonal protein in the serum or the urine (SPEP/UPEP – these values are usually lower than in the major criteria), multiple “punched-out” lytic bone lesions, end-organ damage (renal insufficiency, hypercalcemia, and anemia), and lower than normal IgG levels. Images: Images will usually show “punched-out” lytic lesions throughout the skeleton. Radiolucent lesions or destructive lesions with no sclerosis (skull lesions and vertebral fractures). Osteopenia is common. There will be a negative bone scan. Minimal osteoblastic activity with multiple myeloma due to the tumoral necrosis factor. Skeletal survey can be used. Sometimes a magnetic resonance imaging (MRI) or positron emission tomography (PET) scan may be used. Bone scans are generally not done in cases of multiple myeloma (bone scans will be cold). Pathology: Sheets of plasma cells, Eccentric nucleus (clock faced), Signet-ring appearance, Perinuclear clearing, Abundant eosinophilic cytoplasm. Treatment: Usually high-dose chemotherapy. Radiation treatment for progressive lesions, structurally important lesions, or radiation is used to decrease pain. Bone marrow transplant (usually in younger patients). Bisphosphonate decreases bone pain, calcium and the number of lesions. Surgical stabilization is used for prophylactic fixation or prevention of pathological fractures. It can also be used for the treatment of fractures. Become a friend on facebook: http://www.facebook.com/drebraheim Follow me on twitter: https://twitter.com/#!/DrEbraheim_UTMC Donate to the University of Toledo Foundation Department of Orthopaedic Surgery Endowed Chair Fund: https://www.utfoundation.org/foundation/home/Give_Online.aspx?sig=29
Просмотров: 41939 nabil ebraheim
Are bisphosphonates an effective treatment for early stage breast cancer?
Professor Michael Gnant talks about supporting this particular adjuvant therapy and its benefits to the patient. Watch the full video here: http://ecancerpatient.org/video/45
Просмотров: 57 ecancer
Professor Ingunn Holen and research into bisphosphonates for breast cancer
Bisphosphonates are drugs that strengthen bones, and are used to treat osteoporosis, but also to help protect bones when breast cancer spreads to the skeleton – known as secondary breast cancer. Professor Ingunn Holen talks about her research into secondary breast cancer, and how bisphosphonates could be used to treat the disease in the future. Read more about Professor Holen’s research:
Просмотров: 334 Breast Cancer Now
Dr. Aft on Bisphosphonates for Breast Cancer
Rebecca L. Aft, MD, PhD, Professor of Surgery at the Washington University School of Medicine in St. Louis and a physician at Siteman Cancer Center, discusses the use of bisphosphonates for patients with breast cancer. More on breast cancer: http://www.onclive.com/specialty/breast-cancer
Просмотров: 116 OncLiveTV
Cancer and Its Effects On Bones
Encouraging news to help cancer patients manage their bone health New Data Presented at the Annual San Antonio Breast Cancer Symposium Adam Brufsky, MD, one of the nations leading breast cancer oncologists and researchers. -Assistant Professor of Medicine, Associate Division Chief for the Division of Hematology/Oncology, University of Pittsburgh School of Medicine -Co-Director, Comprehensive Breast Cancer Center; Medical Director, Women's Cancer Center at Magee Womens Hospital/UPCI, Pittsburgh, PA Even following treatment, people diagnosed with cancer still face the risk that their cancer may spread, or metastasize, to another part of their body, most commonly their bones. These bone metastases break down the bone, often leading to painful complications that can affect patients quality of life. In addition, certain cancer therapies can also affect the integrity of the bones. Treatments such as aromatase inhibitors, a class of drugs used to help treat breast cancer patients can sometimes also lead to bone loss. Results from data presented at the recent San Antonio Breast Cancer Symposium demonstrates the advantages of treatment with bisphosphonates, which are used to treat bone complications associated with cancer, in helping to improve and maintain bone health. Data showed that the use of bisphosphonates taken in conjunction with an aromatase inhibitor following surgery may significantly reduce the risk of fracture. Physician Biography: Dr. Adam Brufsky Medical Oncology Adam M. Brufsky, MD, PhD, is currently Assistant Professor of Medicine at the University of Pittsburgh School of Medicine. He serves as Co-Director, Comprehensive Breast Cancer Center and Medical Director, Women's Cancer Center at the Magee Womens Hospital/UPCI, Pittsburgh, PA. He also serves as the Associate Division Chief for the Division of Hematology/Oncology within the University of Pittsburgh School of Medicine's Department of Medicine. He earned his MD and his PhD from the University of Connecticut School of Medicine in Farmington, CT, completed a residency at Brigham and Women's Hospital, Harvard Medical School, and a Fellowship at Dana-Farber Cancer Institute. Dr. Brufsky is board certified in Internal Medicine and Medical Oncology by the American Board of Internal Medicine. An active researcher, he has numerous abstracts and research articles in leading journals, and is Principal Investigator on a number of research grants funded by the National Institutes of Health, Susan G. Komen Foundation, and US Army Breast Cancer Research Program.
Просмотров: 1695 GoodNewsBroadcast
FDA Urges Caution Over Long-Term Use of Bone-Density-Building Drugs
Millions of women grapple with whether to take bone-density-building drugs to treat or prevent osteoporosis, but the FDA this week warned that long-term use of bisphosphonates can lead to rare fractures and side effects. Margaret Warner and Maine Medical Center's Dr. Clifford Rosen discuss the risks outlined by the FDA.
Просмотров: 3318 PBS NewsHour
Bisphosphonates: Safety and Effectiveness for Osteoporosis Treatment - Susan Ott, M.D.
Watch the full video online at http://onlinesymposia.com/online-videos/27-ccr2012
Просмотров: 1987 OnlineSymposia
Risk Factors And Medications For Osteoporosis - Manipal Hospitals
Osteoporosis is a condition where bones weaken and tend to break faster. People having osteoporosis have abnormally finned bones with larger holes in spongy bones. There are two types of osteoporosis know as primary osteoporosis, which is seen in old people and women, and Secondary osteoporosis, seen in both children and adults. It is also related to hormonal problems, certain medications and cancer. It occurs after the age of thirty. This video is an informative animated presentation that explains in detail about Osteoporosis. Bones contain cells called osteoclasts that breakdown bone tissue. Other cells called osteoblasts make new bone tissue using minerals such as calcium and phosphate from the blood. Hormones such as estrogen, growth hormones and testosterone help keep the number and activity of osteoblasts higher than osteoclast, so that more bone is made than removed. Osteoporosis is a condition that leads to weaken bones, causing them to break more easily. Healthy bone is dense enough to support and protect the body, and to handle the stresses of movement & minor injuries. However, people with osteoporosis have abnormally thin bones with larger holes in the spongy bone. There are two types of osteoporosis; primary osteoporosis is usually related to older age, secondary osteoporosis affects both children and adults. A person has a greater risk for either type of osteoporosis, if they don’t develop enough bone mass when they are growing from childhood to adulthood. Watch the video to know more in detail about Osteoporosis. Best Hospital in India: Manipal Hospitals is one of the top multi-specialty hospital in India located at all major cities like Bangalore, Vijayawada, Visakhapatnam, Goa, Salem, Jaipur, Mangalore. Provides world class 24/7 Emergency services. Our top surgeons are expertise in offering best treatment for Heart, Brain, Cancer, Eye, Kidney, Joint replacement surgery & all major surgeries at affordable cost. Health Check-up packages are also available. To know more visit our website : https://www.manipalhospitals.com/ Get Connected Here: ================== Facebook: https://www.facebook.com/ManipalHospitalsIndia Google+: https://plus.google.com/111550660990613118698 Twitter: https://twitter.com/ManipalHealth Pinterest: https://in.pinterest.com/manipalhospital Linkedin: https://www.linkedin.com/company/manipal-hospital Instagram: https://www.instagram.com/manipalhospitals/ Foursquare: https://foursquare.com/manipalhealth Alexa: http://www.alexa.com/siteinfo/manipalhospitals.com Blog: https://www.manipalhospitals.com/blog/
Просмотров: 2768 Manipal Hospitals
Advances in prevention and treatment of bone metastases in prostate cancer
Winston Tan, MD of Mayo Clinic, Jacksonville, FL discusses a treatment of bone metastases in prostate cancer. Dr Tan mentions that addition of bisphosphonates does not increase the overall survival of patients suffering from various cancer types, including breast cancer, prostate cancer, and renal cancer. Cabozantinib, approved for metastatic renal cancer makes the bone metastases disappear, however, it has not been shown to increase survival in patients with a metastatic prostate cancer in a phase III randomised clinical trial. A combination of two or three drugs may be required to achieve better results in patients. The next step would be to look at markers, a combination of targets and drugs which can work together to help improve survival and prevent the consequences of bone metastases. Dr Tan highlights the importance of supportive care for cancer patients, who can benefit from an access to physical therapists, psychologists, and nutritionists. This could mean less bone pain and decreased use of pain medication, which may cause dizziness, constipation, or reduced mobility. Ongoing studies in the metastatic prostate cancer compare the micro-environmental factors, before and after the treatment to better understand which genetic and metabolic factors affect the bone metastases. Dr Tan says that prostate cancer patients with bone pain should be offered Radium 223, which improves survival and long-term can improve the symptomatology, and bisphosphonates, or denosumab, which is known to prevent skeletal-related events. Recorded at the Multinational Association of Supportive Care in Cancer (MASCC) and International Society of Ocular Oncology (ISOO) 2016 Annual Meeting on Supportive Care in Cancer held in Adelaide, Australia.
Просмотров: 408 VJOncology
Osteonecrosis of Jaw
Просмотров: 5810 Heath and Beauty
Which bisphosphonate causes osteonecrosis of the jaw
Which bisphosphonate causes osteonecrosis of the jaw - Find out more explanation for : 'Which bisphosphonate causes osteonecrosis of the jaw' only from this channel. Information Source: google
Просмотров: 23 atunakai6a
Attorney for femur bone fractures from bisphosphonates Fosamax Boniva
Diane Sawyer interviews Dr. Richart Besser regarding the skyrocketing use of the Biophosphonate called Fosamax made by Merch. Taken long-term, Bisphosphonates can cause bones to become weak, brittle and even shear. Many women have reported breaks in their thigh bones. If you or a loved one has suffered serious side effects from taking Fosamax or Boniva, please call our office today at 727-397-9198 for a free consultation or visit us at http://www.hummerlaw.com
Просмотров: 245 hummerlaw
Hypercalcemia - causes, symptoms, diagnosis, treatment, pathology
What is hypercalcemia? Hypercalcemia's a condition in which there are higher than normal levels of free ionized calcium in the blood. Find more videos at http://osms.it/more. Hundreds of thousands of current & future clinicians learn by Osmosis. We have unparalleled tools and materials to prepare you to succeed in school, on board exams, and as a future clinician. Sign up for a free trial at http://osms.it/more. Subscribe to our Youtube channel at http://osms.it/subscribe. Get early access to our upcoming video releases, practice questions, giveaways, and more when you follow us on social media: Facebook: http://osms.it/facebook Twitter: http://osms.it/twitter Instagram: http://osms.it/instagram Our Vision: Everyone who cares for someone will learn by Osmosis. Our Mission: To empower the world’s clinicians and caregivers with the best learning experience possible. Learn more here: http://osms.it/mission Medical disclaimer: Knowledge Diffusion Inc (DBA Osmosis) does not provide medical advice. Osmosis and the content available on Osmosis's properties (Osmosis.org, YouTube, and other channels) do not provide a diagnosis or other recommendation for treatment and are not a substitute for the professional judgment of a healthcare professional in diagnosis and treatment of any person or animal. The determination of the need for medical services and the types of healthcare to be provided to a patient are decisions that should be made only by a physician or other licensed health care provider. Always seek the advice of a physician or other qualified healthcare provider with any questions you have regarding a medical condition.
Просмотров: 158108 Osmosis
Attorney for atrial fibrillation and Fosamax reclast Boniva bisphosphonates
FDA has issued an early communication to health care providers about a possible association between bisphosphonates such as Fosamax, Reclast, Boniva, etc and serious atrial fibrillation, a common type of cardiac arrhythmia (irregular heart beat). If you or a loved one has suffered serious side effects from taking Fosamax or Boniva, please call our office today at 727-397-9198 for a free consultation or visit us at http://www.hummerlaw.com
Просмотров: 143 hummerlaw
Clodronate Is An Absolute Must for Bone and Breast Cancer Patients - Fitnessential
Clodronate Prevents Breast Cancer : http://www.Fitnessential.co/ Find out more about Clodronate Is An Absolute Must for Bone and Breast Cancer Patients Clodronate Prevents Breast Cancer The treatment of clodronate stops breast cancer from spreading to bone cancer. NOTE: Unavailable in United states. The meals FDA's suppression of clodronate has caused the needless death of around 30, 000 American women every year! Clodronate belongs to a band of drugs which are called bisphosphonates. Bisphosphonates are generally used in treating bone thinning (osteoporosis). In a few situations, they could protect your bones against a number of the ramifications of secondary cancer of the bones, such as for example pain and weakness. Secondary bone cancer occurs if the original (primary) cancer spreads to form a second cancer (metastasis) in the bone. Clodronate is often given alongside other cancer treatments. As well as getting used in some types of secondary bone cancer, it is often been shown to be effective in people who have myeloma (cancer of plasma cells in the blood). Additionally it is used to lower an increasing calcium levels in the blood. Because of secondary cancer of the bone, calcium, which helps fortify the bones, may be lost from the damaged bone and seep to the bloodstream. An increasing amount of calcium in the blood is recognized as hypercalcaemia. This may cause symptoms like for example feeling/being sick (nausea and/or vomiting), tiredness, irritability and even confusion. Clodronate might help reduce high degrees of calcium. Secondary cancer inside the bones may make them weak, and in some situations they might break (fracture). Clodronate might help restrengthen the bones and decrease the risk of fractures. Cancer can impact the bones in different ways, and clodronate isn't helpful for all cancers that affect the bones. Your doctor or specialist nurse can tell you if it would be helpful for you. In normal bone, two types of cells called osteoclasts and osteoblasts come together constantly to shape, rebuild and strengthen existing bone: osteoclasts which destroy old bone and osteoblasts which build new bone. Myeloma and some secondary bone cancers can produce chemicals that produce the osteoclasts work harder. Which means that more bone is destroyed than rebuilt, that leads to weakening of the affected bone. This may hurt and ensures that the bone can fracture or break easier. Clodronate targets areas of bone where the osteoclast activity is high. It helps bring the total amount of osteoclast and osteoblast activity back again to normal by reducing the experience of the osteoclasts. This may reduce pain and help fortify the bone. Additionally, it ensures that less calcium is likely to be lost from the bones. Clodronate is given as a tablet or capsule, frequently taken a couple of times each day. It is recommended that you just take the tablet or capsule in the morning and evening, and not within one or two hours of eating, having a milky drink or taking other medicines. It is because it's harder it to be absorbed to the bloodstream, which can make it much less effective. Avoid using clodronate with mineral supplements, such as for example multi-minerals, for the exact same reason. Read more about this on my blog at: http://www.fitnessential.co/blog/clodronate-stops-breast-cancer-in-its-tracks
Просмотров: 711 TheFitnessential
Fosamax Drug Injury Lawyer
Fosamax is part of a class of drugs known as bisphosphonates, which are used to treat osteoporosis and bone pain caused by some types of cancer. Fosamax is the most commonly dispensed bisphosphonate in the United States and accounted for 22 million prescriptions by 2004 (2). Bisphosphonates are often used in the management of certain cancers—such as lung, breast, prostate, and multiple myeloma—where cancer has metastasized (spread) to the bone.
Просмотров: 1839 DrugLawyers
Metastatic bone pain
©Geoffrey L. Cheung , M.Sc.Biomedical Communications 2010 Co-supervisors: Linda Wilson-Pauwels, University of Toronto, and Philippe Sarret, Université de Sherbrooke
Potential Risks of Osteoporosis Medications
MedStar NRH's Dr. Robert Bunning has conducted extensive research on how osteoporosis medications called bisphosphonates may cause sudden bone breaks and fractures. He provides insight on the subject in this piece that originally aired on Channel 4 News (NBC4) in Washington, DC. Learn more about Orthopaedic Injuries and Post-Surgical Services: http://ow.ly/OWe1i Learn more about Dr. Bunning: http://ow.ly/OWelL
Просмотров: 557 MedStar National Rehabilitation Network
Dr. Julie Gralow on Treating Breast Cancer Bone Metastases
Julie R. Gralow, MD, Director, Breast Medical Oncology, Seattle Cancer Care Alliance, discusses the recent changes occurring in the anti-osteoclastic targeted therapies used to treat breast cancer bone metastases. The bisphosphonates zoledronic acid (Zometa) and Pamidronate (Aredia) have traditionally been used to treat breast cancer bone metastases. These agents work by blocking the cells that cause bone destruction, which prevents the loss of bone mass. Recently the agent denosumab (Xgeva), a RANK-ligand inhibitor, has become available. In comparison trials, at new diagnosis, between denosumab and bisphosphonates, denosumab proved superior at reducing skeletal-related events and improving other quality of life measures. Gralow advocates for using denosumab in the first-line, when appropriate, or in the second-line after progression on zoledronic acid. Denosumab can be delivered subcutaneously with fewer concerns over serum creatinine levels or first infusion reactions. With the addition of new agents there are now multiple choices for metastatic breast cancer. Trials have now begun to investigate dosing schedules to optimize delivery. The OPTIMIZE-2 trial examined bisphosphonate dosing schedules to determine if they should be given monthly, or every 3 months. Providing therapy every 3 months would reduce many of the adverse events associated with the treatment, such as osteonecrosis of the jaw.
Просмотров: 3032 OncLiveTV
Osteonecrosis - Causes, Symptoms, Treatments & More…
See much more honest health information at: http://www.rehealthify.com/ Rehealthify offers reliable, up-to-date health information, anytime, anywhere, for free. -- video script below -- Osteonecrosis is a disease caused by reduced blood flow to bones in the joints. In people with healthy bones, new bone is always replacing old bone. In osteonecrosis, the lack of blood causes the bone to break down faster than the body can make enough new bone. The bone starts to die and may break down. You can have osteonecrosis in one or several bones. It is most common in the upper leg. Other common sites are your upper arm and your knees, shoulders and ankles. The disease can affect men and women of any age, but it usually strikes in your thirties, forties or fifties. At first, you might not have any symptoms. As the disease gets worse, you will probably have joint pain that becomes more severe. You may not be able to bend or move the affected joint very well. No one is sure what causes the disease. Risk factors include Long-term steroid treatment Alcohol abuse Joint injuries Having certain diseases, including arthritis and cancer Doctors use imaging tests and other tests to diagnose osteonecrosis. Treatments include medicines, using crutches, limiting activities that put weight on the affected joints, electrical stimulation and surgery. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases
Просмотров: 11455 Rehealthify
Cancer Treatment
This video has information about all the main cancer treatments, including surgery, radiotherapy, chemotherapy, hormone therapy, biological therapies, bisphosphonates and bone marrow and stem cell transplants. There is also information about complementary and alternative therapies. ----------------------------------------------- Find This Video Helpful? Please click below to share my website with friends & family. For more information check out: Our Website: goo.gl/4i6ovK Our Facebook Page: goo.gl/Ynt1qg Our Youtube Channel: goo.gl/glWkzo
Просмотров: 223 Medical.Animation.Videos.Library
Bisphosphonates and femoral fracture
Dr. Broussard reviews adverse events from long term use of osteoporosis medications.
Просмотров: 123 Andre Broussard, D.C.
Bisphosphonates: For Healthy and Strong Bones?
Bisphosphonates are prescribed to help keep the bones strong and healthy, consequently reducing the risk of osteoporosis. Are there risks on taking these kind of drugs? Are there serious side effects? For more information, visit http://www.hummerlaw.com or call Hummer Law Offices at 1-800-433-8420.
Просмотров: 167 chuckrightontop
A 81 year old lady was admitted with a fall resulting in a fracture of her left neck of femur. She had a history of osteoporosis and was taking Alendronate one tablet per week and Clopidogrel. The Orthopaedic surgeons sorted her out with a dynamic hip screw. Five days after the operation she developed coffee ground vomiting but no melaena. The Hb dropped to 8.2 g/dl but the urea did not rise (4.2). A OGD was performed (see video)… Bisphosphonates act as topical irritants to the GI lining resulting in chemical oesophagitis. It is hypothesized that bisphosphonates compromise the protective, hydrophobic mucosal barrier of the GI tract allowing gastric acid to agitate the epithelial lining. Phospholipids line the luminal side of the GI tract and have both a positive and negative charge (zwitterionic in nature). The zwitterionic alignment of phospholipids creates a protective hydrophobic barrier between the epithelial lining and the acidic environment in the lumen of the GI tract. When positively charged hydrogen molecules come into contact with the phospholipid bilayer, the hydrogen molecules are unable to penetrate through the bilayer, given the hydrophobic environment. Phosphatidylcholine is one of the phospholipids responsible for the hydrophobic properties of the bilayer. The comparable molecular structure of bisphosphonates and phosphatidylcholine create competitive binding on the gastrointestinal lining. When bisphosphonates bind, the hydrophobic barrier is destroyed, and gastric acid is able to reach the epithelium resulting in irritation. Reference Steber CJ, 2015, Evidence-based Medicine, Bisphosphonates Mechanism of Esophageal and Gastrointestinal Irritation http://www.ebmconsult.com/articles/what-is-the-mechanism-by-which-bisphosphonates-cause-esophageal-and-gastrointestinal-irritation
Просмотров: 143 monzahmed
Breast cancer and osteoporosis:  the link between them
Powerful chemotherapy drugs and estrogen-blocking hormone treatments are highly effective in treating breast cancer. But in the process they may be putting women at risk of another disease: osteoporosis.
Просмотров: 1811 Michigan Medicine
Prostate Cancer and Bone Metastasis
The most common place for prostate cancer to spread is to the bone. The spread of the prostate cancer to the bones (bone metastases) can cause severe pain and fracture, and hormonal therapy for prostate cancer can cause bone loss, fracture, and joint pain.
Просмотров: 33075 ZERO - The End of Prostate Cancer
New study on osteoporosis drugs, breast cancer
The most-widely used osteoporosis drugs may not protect women from breast cancer after all. Also, a new look at the science of sleep medication shows there may be little evidence the drugs provide much benefits. Wendy Gillette reports on the day's top medical headlines.
Просмотров: 379 CBS This Morning
Pharma Tube - 61 - Bone & Joint - 4 - Osteoporosis [HD]
فارما تيوب Pharma Tube هى سلسلة من الفيديوهات تحتوى على محاضرات فى علم الفارماكولوجى الأساسى والإكلينيكى يقدمها الصيدلى دهشان حسن دهشان الشرح من كتاب فارما جايد Pharma Guide Pharma Tube is a series of videos containing lectures about basic and clinical pharmacology which prepared from Pharma Guide book, by Pharmacist; Dahshan Hassan Dahshan. ** موضوعات هذة الحلقة: Osteoporosis * نظرة عامة حول المرض * معدل الإنتشار * عوامل الخطورة * الجزء الفسيولوجى فى الحلقة " Bone Metabolism" * وظائف Parathyroid Hormone * ما هو Bone Mineral Density (BMD * انواع ال Primary وال Secondary من ال Osteoporosis * التشخيص والتعريف بجهاز DXA * معرفة نظام FRAX لحساب نسبة ال risk * الاختبارات المعملية لإستبعاد الامراض المشابه مثل Paget's disease و osteomalacia و multiple myeloma * العلاج الغير دوائى ومعرفة الإحتياجات اليومية من الكالسيوم وفيتامين د * العلاج الدوائى - مكملات الكالسيوم وفيتامين د - عائلة ال Bisphosphonates - عائلة Selective Estrogen Receptor Modulators - Calcitonin Hormone - Denosumab - Parathyroid Hormone (Teriparatide ) * Guidelines Summary * اخيرا فقرة الصيدلية ******************** للإنضمام لفريق عمل مطورون كتاب فارما جايد .. إنضم الى جروب “Pharma Guide Developers” https://goo.gl/cxmhz8 لمعلومات أكثر عن الكتاب For more information about Pharma Guide book, click here https://goo.gl/izPQDe للتواصل مع المؤلف For contact with the author https://goo.gl/6qRWyN هذه المحاضرات للمختصين في المجال الطبي، الصيادلة ، الأطباء ، أطباء الأسنان أو التمريض، وعلى الرغم من هذا فقد لا تتوافق مع النظم الصحية المعمول بها في بلدك فبرجاء مراجعتها أولاً. These lectures for specialists in the medical field, pharmacists, physicians, dentists or nurses and although this may not conform with applicable in your country health systems sure to first review.
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39 Bone Mets
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Prostate Cancer: Diet
read more on the link : Researchers from Canada have found that having a diet of red meat, organ meats, soft drink and bottled water increased the risk of getting prostate cancer. They compared the diets of 80 men with prostate cancer, and 334 healthy men, and the diet just described more than doubled the risk of developing prostate cancer. So what prostate diet can reduce the risk of prostate cancer? Swedish researchers examined the diet of 1499 men with prostate cancer and 1130 men who were healthy, and they published their findings in the Cancer Causes and Control journal. They found that eating foods rich in phytoestrogens decreased the risk of prostate cancer. Phytoestrogens are plant molecules that have a weak estrogenic effect. They are made converted in the intestines from plant precursors by bacteria as they digest food. They are taken up by the same parts of the body that process the hormone estrogen. Interestingly, one of the treatments for prostate cancer by doctors involves using estrogens to reduce the level of testosterone in men with advanced prostate cancer. It does this indirectly, through its effect on the hypothalamus, as less luteinizing hormone releasing hormone is produced by the hypothalamus. This means not as much luteinizing hormone is released by the body, which suppresses the production of testosterone. High doses of estrogens for men can lead to cardiovascular complications. But phytoestrogens obtained from diet, in less quantities than a drug, and with a milder effect to start with, should not pose a problem. And researchers don't yet know what exactly causes phytoestrogens to have such a protective effect, whether it is similar to that of the estrogen treatment for advanced prostate cancers. And they don't know which phytoestrogens are the most active. So what phytoestrogen foods could you include in a diet for a healthy prostate? Soy beans and nuts are a good source. Soy and nuts contain a type of phytoestrogen called isoflavones, whilst berries and seeds contain lignans. Foods could include peanuts, sunflower seeds, peanuts, and berries. The only possible concerns with soy is that a study in mice found that male mice that had a type of heart disease that people also have, suffered heart failure when fed a soy based diet. Whether this extrapolates to the human population is yet to be established. But it may be wise for those me who have this particular genetic heart condition, dilated cardiomyopathy, to be cautious about soy products in their diet. But for other men, soy products could be good news. A meta analysis, which is a study of related studies, published in the International Journal of Cancer, found that diets high in soy lowered men's risk of prostate cancer by 30%. Another important mineral to consider for men is zinc. Zinc is used by men's bodies to make some of the male hormones, and for general prostate health. A deficiency in zinc can lead to problems with the testicles, the prostate, and the health of the sperm. Foods that are great sources of zinc include seeds like pumpkin, sesame, and sunflower; nuts like almonds, brazil, cashews and walnuts; and foods like lettuce, oats and onions. Raw onion is particularly suggested by Paul Bedson, a natural therapist. He also suggests vegetable juice made of equal parts of beetroot, carrot, and cucumber in cases where the prostate gland is enlarged. Cranberry juice, a cup drunk three times a day, is also recommended in this case. prostate, prostrate, cancer, prostate cancer, diagnosing prostate cancer, symptoms of prostate cancer, information on prostate cancer, prostate cancer treatment, mens cancer, men's cancer, PSA, psa, therapy, hormone, symptoms, prostatectomy, brachytherapy, cryosurgery, metastatic, 3D conformal, information, diet, research, radiation, radiotherapy, prevention, screening, localised, support, surgery, awareness, treatment, advanced, donation, symptom, bracytherapy, prostatic, gleason, tookit, Tool Kit, gleason score, biopsy, psa test, prostate gland, prostate specific antigen, HIFU, hifu, bisphosphonates, cryotherapy, health professionals, charity, men, campaigning, fundraising, gland, helpline, prostate cancer publications, prostate cancer booklets, diagnosed, palliative radiotherapy, chemotherapy, continence, events, fundraise, campaign, specialist nurses, african caribbean, prostate cancer charity, prostate cancer symptoms, trus, prostate problems, prostate cancer awareness month, prostate biopsy, gleason grading, DRE, BPH, prostatitis, localised prostate cancer, locally advanced prostate cancer, advanced prostate cancer, active surveillance, hormone therapy, high dose rate brachytherapy, bisphosphonates, palliative radiotherapy, clinical trials, HIFU,Prostate cancer, PSA,prostate cancer, oncology, medical animation, health app, educational, prostate cancer animated video, prostate cancer information, prostate cancer video
Просмотров: 5335 prostate cancer
Treating Bone Mass Loss in Prostate Cancer Patients
Androgen-Deprivation treatment can increase a man's risk for developing bone loss. Several hormones protect bones from losing density and testosterone is one of theses. Androgen-Deprivation treatment causes testosterone levels to go down and bone loss starts to occur at an increasing rate. There are some medications you can use to help maintain your bone mass. Certified Physicians Assistant Jennifer Wilson discusses what these medications are and how they work in this video. VIEW THE ARTICLE: How to Increase Bone Mass in Patients with Prostate Cancer - http://www.prostatecancerlive.com/?p=13723 SUBSCRIBE FOR MORE EXPERT INFORMATION AND BREAKING PROSTATE CANCER NEWS http://youtube.com/subscription_cente... VISIT PROSTATECANCERLIVE.com FOR TONS OF INFORMATIVE VIDEOS http://www.prostatecancerlive.com/# SUGGEST THE NEXT TOPIC FOR OUR PROSTATE CANCER EXPERTS! http://www.prostatecancerlive.com/# CONNECT WITH US! Google+: http://bit.ly/17F4WQr Facebook: https://www.facebook.com/pages/ProstateCancerLive Twitter: https://twitter.com/ProstateLive
Просмотров: 332 Prostate Cancer Live
Dentist's role in osteonecrosis of the jaw management
Sharon Liberali, BDS (Adel), DClinDent (FICD, FPFA, FRACDS) of Adelaide Dental Hospital, Adelaide, Australia, emphasizes the importance of the treatment planning process for the dentist, in order for them to analyze and project which teeth are at risk of osteonecrosis of the jaw (ONJ). Bisphosphonates have a strong affinity for the bone, even if patients have stopped taking the medication for quite some time. The bone remembers these drugs in the system, therefore the risk of ONJ is almost lifelong for these patients. Dr. Liberali mentions that dentists have a clinical responsibility for a soft tissue examination, as well as teeth examination in order to search for and identify spontaneous osteonecrosis of the jaw. Dentists sometimes have to perform extractions, of which there is a protocol to follow in order to implement that safely for patients that have had either bisphosphonates or the autologous stem cell transplant. Recorded at the Multinational Association of Supportive Care in Cancer (MASCC) and International Society of Ocular Oncology (ISOO) 2016 Annual Meeting on Supportive Care in Cancer held in Adelaide, Australia.
Просмотров: 339 VJOncology