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Role of PPARγ in HCC – Video abstract 48512
 
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Video abstract of a review paper “Emerging role of the peroxisome proliferator-activated receptor-gamma in hepatocellular carcinoma” published in the open access Journal of Hepatocellular Carcinoma by Hsu HT and Chi CW. Abstract: Hepatocellular carcinoma (HCC) is the major leading cause of cancer death worldwide. Hepatitis B virus, hepatitis C virus, alcohol consumption, non-alcoholic fatty liver disease, and diabetes are the major risks for developing HCC. Until now, recurrence and metastasis are the major cause of death in HCC patients. Therefore, identification of new effective molecular targets is an urgent need for treatment of HCC. Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated nuclear receptor which could be activated by PPARγ agonists such as thiazolidinediones, and natural PPARγ ligand (such as 15-deoxy-Δ12,14-prostaglandin J2, 15d-PGJ2). Increasing in vitro and in vivo evidence has demonstrated that PPARγ agonists exhibit an inhibitory role on tumor cell growth, migration, and invasion, suggesting that PPARγ activation may play an important role in the regulation of growth of HCC. It has been reported that PPARγ activation by thiazolidinediones or overexpression of PPARγ by virus-mediated gene transfer has shown growth inhibitory effects in hepatoma cells, but the expression level of PPARγ in HCC tissues still remains conflicting. Notably, a novel PPARγ agonist, honokiol, has recently been found to activate the PPARγ/RXR heterodimer, and has also exhibited significant anti-cancer effects in hepatoma cells. In the present review, we summarized studies on the role and the molecular regulation of PPARγ in HCC development in vitro and in vivo. PPARγ has the potential to be a therapeutic target for future treatment of HCC. Read the full paper here: http://www.dovepress.com/emerging-role-of-the-peroxisome-proliferator-activated-receptor-gamma--peer-reviewed-article-JHC
Просмотров: 404 Dove Medical Press
Cancer: cMET Pathway
 
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Video on the mechanisms of the cMET signalling pathway and potential therapeutic implications Association website: http://www.efp-online.fr Online education: http://www.invivoveritas.fr
Просмотров: 11380 AssoEFP
ITOC 2014: Toll like receptor 7 agonists for cancer immunotherapy
 
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Visit http://www.ecancer.org for more Prof Stefan Endres - Ludwig-Maximilians-Universität, Munich, Germany talks to ecancertv at the 1st Immunotherapy of Cancer Conference (ITOC) in Munich about toll like receptor 7 agonists for cancer immunotherapy. Visit www.ecancer.org for more. Toll like receptor 7 (TLR7) is from a class of proteins that play a key role in the innate immune system. One approach is to combine TLR7 RNA with a chemical from the triphosphate group, inducing interferon and alpha helping the immune system to fight tumour cells. Dr Endres covers the different approaches for activating the patient's own immune system to fight cancer.
Просмотров: 349 ecancer
PPARs - LIVE BLOOD ANALYSIS
 
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Recognized by medical researchers as "the most important bio-molecular discovery" in the 21st century, PPARs represent the best supplement available for your cellular health. It is also hailed as one of the most promising leads into the area of anti-aging research. In a study conducted by the Division of Biotechnology and Pharmaceutics, National Health Research Institutes, Taiwan, Cryptomonadales is the only known algae in the world containing significant amounts of all three naturally occurring Alpha, Beta, and Gamma PPARs. Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor super family of ligand-activated transcription factors that are related to retinoid, steroid and thyroid hormone receptors. PPARs play an important role in many cellular functions including lipid metabolism, cell proliferation, differentiation, adipogenesis and inflammatory signalling. PPARα helps in Liver, heart and bones PPARβ/δhelps in Skin, bone, muscles PPARγ helps in Lipid, Colon and other organs. All 3 isoforms of PPARs: helps in blood system and immune system. The 3 isoforms of alpha, beta and gamma can potentially help lipid metabolism, glucose homeostasis, anti-inflammation, immunoregulation and cell differentiation (cancer). It has shown major breakthrough to treat metabolism syndrome (diabetes mellitus, obesity, hyper-cholesterolemia and hypertension) and improve control of cardiovascular diseases like stroke and myocardial infarction. http://cryptomonadalesppar.wordpress.com htt://meridianlifestyle.blogspot.com JANET C. BORJA +639228289128 / +639194827899 EMAIL: anginett@gmail.com YM: anginett888 SKYPE: janetborja
Просмотров: 2020 Anginett Catungal
Acute DVT recovery- Just maybe some hope?
 
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PPar gamma agonists are meds that can let your body build additional collateral veins to help ease the vise grip of DVT's on circulation. It's an off-label use for an existing FDA approved medicine used to treat diabetes mellitus. Interestingly, this incredible vein growth attribute was one of several good things done by this med. This all came out in the pre-market research. The literature will talk about improvements in cholesterol, lower glucose, better mental funtioning, etc. I really can't address those issues except for the glucose and shedding some pounds. As a highly motivated competitor you are used to sticking to regimens. You now need to eat right and exercise regularly. Unless you are significantly impaired with permanent type DVT's you really don't need to watch this. This clip is for those individuals for whom being faced with a rather non-functional, non-productive lifestyle would be more stressful and possibly promote greater health risks than doing nothing. There is an implied risk of bladder cancer with this med. After searching the N.I.H data bases and examining about 100 scientific papers I found only a 1-2% statistical cancer risk. Even that is somewhat questionable and within error range. I face that much risk every time I cross the street. The point is, if you can live with your present situation then why take additional risks? For me, my non-funtionality was simply not acceptable. Despite my vascular docs telling me that I had no options for therapy with my condition I was totally unwilling to accept that. I approached the college of Pharmacology at this large teaching Medical School. This professor was kind enough to mention an off-label use of Actos (generic name: Pioglitazone). Namely, that it creates new vein growth in addition to lowering glucose levels for type 2 diabetics. Within 6 weeks I was achieving unmistakable improvements in physical functioning. It's been about a year since I began these meds. I can now work a full day, I can do things I enjoy like east coast swing dancing, I can do meaningful participation in the sports I loved. I have lost about 15+ pounds and my glucose A1c numbers are 6.5 (down from 7.0). In short...I now have a life. The initial bad claims for Actos came from a study which combined two other meds. It turns out that they were the 'problem' meds linked to cancer. Actos, or pioglitazone, was in fact reasonably safe. The only adverse affect which I think I can attribute to' Pio' is a sore throat which lasted for a couple of weeks or so. Also, you can expect to visibly see your new collateral veins. Mine are most visible around my waist and thigh. Anyway, that is more proof to me that this works. If you are concerned about your image, maybe for photo shoots, then this may not be the med for you. Don't expect this med to get you off of wearing those troublesome compression stockings either....that needs to continue in my opinion (but never really tested otherwise). I certainly would be cautious if you have any kind of known pre-existing cancer, or it you are a nursing mother, etc. These are some of the things you need to look at on your own. I had my prescription filled for 45mg pills. I began by taking half of one of these each day (they are not scored either). Six months later I started taking 3/4 of a pill per day. With no insurance you can expect to pay about $250 for a 90 day supply. With insurance you might have a co-pay of about $50. To date, nothing in my lab work indicates any cancer of any kind. It was with great trepidation that I decided to express what this med can do. I think some people might abuse it's use somehow. And nothing works for everybody...the great caveat. You might try this. I am not recommending it because I have no authority to do so but I do have a life now. You might even achieve better gains than I because I entered the DVT nightmare experience after having total replacements on both knees, back surgery, and a few other things. But I'm 'good to go' now. Today I exercised just over seven miles. Tomorrow, I will be rappelling off my roof to fix some chimney mortar. Then back to gardening. Well, you get the picture. The best to you. 'Doc' Ben
Просмотров: 1839 32f3245f4
Genetics and Genomics of Thyroid Neoplasms: Moving Closer towards Personalized Patient Care
 
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December 6, 2013 - The 2013-2014 Genomics in Medicine Lecture Series (Speaker: Electron Kebebew) More: http://www.genome.gov/27553517
Просмотров: 2019 National Human Genome Research Institute
PPARs - CRYPTOMONADALES
 
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PubMed U.S. National Library of Medicine National Institutes of Health [PPAR and diabetes]. [Article in Japanese] Terauchi Y, Kadowaki T. Source Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo. Abstract The peroxisome proliferator-activated receptors (PPARs) are nuclear fatty acid receptors that have been implicated to play crucial roles in metabolic diseases such as hyperlipidemia, insulin resistance, and diabetes. The three PPAR subtypes, alpha, gamma, and delta, have distinct expression patterns and regulate glucose homeostasis based on the need of a specific tissue. While PPARalpha potentiates fatty acid catabolism in the liver and is the molecular target of the lipid-lowering fibrates, PPARgamma is essential for adipocyte differentiation and hypertrophy, and mediates the activity of the insulin sensitizing thiazolidinediones. PPARdelta may be important in regulating body weight and lipid metabolism in fat tissues. Thus, uncovering the regulatory mechanisms and transcriptional targets of these PPARs will provide insights into the pathogenesis of metabolic diseases and offer valuable information for rational drug design. JANET C. BORJA +639228289128 / +639194827899 EMAIL: anginett@gmail.com YM: anginett888 WEBSITE: http://janetborja.com http://cryptomonadalesppar.wordpress.com http://meridianlifestyle.blogspot.com
Просмотров: 13570 Anginett Catungal
Cancer ‘vaccine’ eliminates tumors in mice,‘Amazing, bodywide effects’|part-2|
 
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Cancer ‘vaccine’ eliminates tumors in mice,‘Amazing, bodywide effects’|part-2| Cancer ‘vaccine’ eliminates tumors in mice,‘Amazing, bodywide effects’ Part 1:https://www.youtube.com/watch?v=Zvf6b3Xfjj8 Levy is a pioneer in the field of cancer immunotherapy, in which researchers try to harness the immune system to combat cancer. Research in his laboratory led to the development of rituximab, one of the first monoclonal antibodies approved for use as an anticancer treatment in humans. Some immunotherapy approaches rely on stimulating the immune system throughout the body. Others target naturally occurring checkpoints that limit the anti-cancer activity of immune cells. Still others, like the CAR T-cell therapy recently approved to treat some types of leukemia and lymphomas, require a patient’s immune cells to be removed from the body and genetically engineered to attack the tumor cells. Many of these approaches have been successful, but they each have downsides — from difficult-to-handle side effects to high-cost and lengthy preparation or treatment times. “All of these immunotherapy advances are changing medical practice,” Levy said. “Our approach uses a one-time application of very small amounts of two agents to stimulate the immune cells only within the tumor itself. In the mice, we saw amazing, bodywide effects, including the elimination of tumors all over the animal.” Cancers often exist in a strange kind of limbo with regard to the immune system. Immune cells like T cells recognize the abnormal proteins often present on cancer cells and infiltrate to attack the tumor. However, as the tumor grows, it often devises ways to suppress the activity of the T cells. Levy’s method works to reactivate the cancer-specific T cells by injecting microgram amounts of two agents directly into the tumor site. (A microgram is one-millionth of a gram). One, a short stretch of DNA called a CpG oligonucleotide, works with other nearby immune cells to amplify the expression of an activating receptor called OX40 on the surface of the T cells. The other, an antibody that binds to OX40, activates the T cells to lead the charge against the cancer cells. Because the two agents are injected directly into the tumor, only T cells that have infiltrated it are activated. In effect, these T cells are “prescreened” by the body to recognize only cancer-specific proteins. About US : IMPORTANT NOTE ABOUT VIDEO:- THE VIEWS AND OPINIONS EXPRESSED IN THE MEDIA OR COMMENTS ON THIS CHANNEL/IN THIS VIDEO ARE THOSE OF THE SPEAKERS OR AUTHORS AND DO NOT NECESSARILY REFLECT OR REPRESENT THE VIEWS AND OPINIONS HELD BY THIS CHANNEL'S BROADCASTER. THE IMAGES SOWN IN THIS NEWS IS MAY OR MAY NOT BE EXACTLY RELATED WITH THE NEWS SAID IN THIS VIDEO..ITS JUST FOR ILLUSTRATION PURPOSES... WE are sharing News with we always respect the source should each video, written source of it. Over here, we have contributed to support the electronic page get backlink. There is no copyright infringement intended for the video and/or material used in this video. If you have an issue with posting this, please contact us at ”xxxxxx0175@gmail.com” and we can sort it out. if you have any dispute/issue then msg us, we will reply you with in 24 hours.. Videos can use content-based copyright law contains reasonable use Fair Use .We Bring You All The Latest News & Politics. References/Source/Credits (FAIR USE) : https://goo.gl/Bg4ny1 AUTHOR(WRITER): By researchers at the Stanford University School of Medicine. Copyright Disclaimer: Citation of articles and authors in this report does not imply ownership. Works and images presented here fall under Fair Use Section 107 and are used for commentary on globally significant newsworthy events. Under Section 107 of the Copyright Act 1976, allowance is made for fair use for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Do you have any query or need any support then Contact us at ”xxxxxx0175@gmail.com”, we are happy to communicate with you, WE WILL REPLY TO YOU WITH IN 24 HOURS..Thanks Keep Your support always
Просмотров: 233 TicK TocK NeWs
Effect of senescence on bone remodelling: the role of inflammageing - Lia Ginaldi
 
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Osteoporosis is a major cause of morbidity and mortality in older people. Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue with a subsequent increase in bone fragility and susceptibility to fractures. There are a large number of risk factors for the development of senile osteoporosis. However, recent discoveries suggest that inflammageing, i.e. the immunological inflammatory profile characterizing immune senescence, plays a major role in bone remodelling through pro-inflammatory cytokines, which are able to influence osteoclasts and osteoblasts. Therefore ageing induces osteoporosis through immunologically mediated modulation of bone remodelling. It is the activated immune profile which, through inflammation and inflammatory cytokine production, modulates osteoblast and osteoclast activity leading to osteoporosis. Senile osteoporosis is an example of the central role of immune-mediated inflammation in determining bone resorption. Here we discuss the pathogenesis of osteoporosis in the context of immunosenescence and focus on therapeutic strategies targeting osteoimmunology pathways. Osteoimmunology is an emerging research area that deals with the mutual interactions between bone and the immune system. Osteoclast, the sole resorbing bone cell, is the center of attention in osteoimmunological research, due to its haematopoietic origin and strong activation through cytokines. However, novel functions of osteoblasts, specialized in bone formation, and osteocytes, the structural bone cells, have also been recently unraveled. Critical proteins with osteoimmune functions, including the pro-osteoclastic cytokine receptor activator of NF-ĸB ligand and inhibitors of the pro-osteoblastic Wnt signaling pathway, recently showed roles of paramount importance in both inflammageing and osteoporosis. The combined effects of estrogen deprivation and raising of FSH production occurring in menopause cause a marked stimulation of bone resorption and a rapid bone loss which is central for the onset of postmenopausal osteoporosis and chronic inflammatory diseases. These discoveries have also led to the development of targeted therapies to counteract not only inflammation-induced bone loss but also postmenopausal and senile osteoporosis. Ageing also affects bone through the production of myeloid cells in bone marrow, a condition associated with increased chronic inflammation by macrophages and decreased bone mass due to excess bone resorption by osteoclasts. The ageing of both haematopoietic stem cells and bone marrow microenvironment, emerging from increased oxidative stress, peroxisome proliferator-activated receptor γ activity and adipogenesis in the ageing bone marrow, contribute to impaired osteoblastogenesis and niche cell function. Anti-ageing interventions targeting mesenchymal stem cell differentiation in the bone marrow could enhance osteoblastic bone formation and counteract inflammation and osteoclastic bone loss. The inducer cells in senile osteoporosis are immune cells, such as activated macrophages and lymphocytes, which produce cytokines and soluble mediators able to stimulate osteoclast differentiation and activation. Molecules that regulate osteoclastogenesis are key factors in many immunological functions. Osteoporosis and inflammageing share the same immunological profile. Osteoclastogenesis and inflammation are directly proportional to osteoclast precursor levels in peripheral blood. Characteristic of an agedi mmune profile is the accumulation of activated memory cells expressing RANKL, preferentially resident in the bone and secreting osteoclastogenic proinflammatory cytokines. The immunophenotypical analysis of peripheral blood lymphocyte subsets confirms the deep involvement of the immune system in bone remodelling. CD3+ T lymphocytes are increased in osteoporotic patients, as well as their CD4+/CD8+ ratio, whereas CD20+ B lymphocytes are significantly decreased. Moreover, the CD8+CD56+ lymphoid subset including killer/effector lymphocytes producing large amounts of the inflammatory cytokine TNF-α, is also expanded. In osteoporotic patients, as well as in elderly people, there is an increase in CD45RO+ memory lymphocytes, whereas the CD45RA+ naive subset is markedly decreased. Another important mechanism which could link inflammageing and osteoporosis is the dysregulation of T-regulatory cells producing soluble factors IL-10 and TGF-β, both able to antagonize immune mediated bone resorption. Visit www.sens.org/videos to view the rest of our SENS6 videos.
Просмотров: 1819 SENS Foundation
What Can Fat Cells Teach Us About Cancer?
 
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Dana-Farber Cancer Institute's Bruce Spiegelman, PhD, explains the importance of fat cell differentiation, energy metabolism and the potential implications of his research for the treatment of cancer.
Просмотров: 456 Dana-Farber Cancer Institute
CRYPTOMONADALES - PPARs
 
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Recognized by medical researchers as the most important bio-molecular discovery in the 21st century, PPARs represent the best supplement available for your cellular health. It is also hailed as one of the most promising leads into the area of anti-aging research. In a study conducted by the Division of Biotechnology and Pharmaceutics, National Health Research Institutes, Taiwan, Cryptomonadales is the only known algae in the world containing significant amounts of all three naturally occurring Alpha, Beta, and Gamma PPARs. Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor super family of ligand-activated transcription factors that are related to retinoid, steroid and thyroid hormone receptors. PPARs play an important role in many cellular functions including lipid metabolism, cell proliferation, differentiation, adipogenesis and inflammatory signalling. PPARα helps in Liver, heart and bones PPARβ/δhelps in Skin, bone, muscles PPARγ helps in Lipid, Colon and other organs. All 3 isoforms of PPARs: helps in blood system and immune system. The 3 isoforms of alpha, beta and gamma can potentially help lipid metabolism, glucose homeostasis, anti-inflammation, immunoregulation and cell differentiation (cancer). It has shown major breakthrough to treat metabolism syndrome (diabetes mellitus, obesity, hyper-cholesterolemia and hypertension) and improve control of cardiovascular diseases like stroke and myocardial infarction. Cryptomonadales PPAR 12 g (Pictures) Concentrated extraction of CGF and PPAR of Cryptomonadales
Просмотров: 11326 Anginett Catungal
What is the role of PPAR agonists in the relationship of inflammation to type 2 diabetes?
 
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Video by Jorge Plutzky, MD, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA Produced by the International Chair on Cardiometabolic Risk
Просмотров: 404 myhealthywaist
THE POWER OF CRYPTOMONADALES
 
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You may not know it but 1 out of 3 people has a SERIOUS AILMENT! THIS IS VERY ALARMING!!! BUT YOU DON'T HAVE TO WORRY ANYMORE... We have THOUSANDS of users that FULLY RECOVERED from various diseases such as: Cancer (all types), Heart Disease, Stroke, Diabetes, Goiter, Lupus, Parkinson, Alzheimer's, Arthritis, Almoranas, Tuberculosis, Myoma, Asthma, HEPA A to H, Epilepsy, Kidney, Gallstone, UTI, Psoriasis, Sinusitis, Dysmenorhea, Dengue, Eczema, Cataract, Glaucoma, Constipation, Skin Problem, etc. Know more about the GREATEST BREAKTHROUGH DISCOVERY against all health disorder!!! CLEANSE, CRYPTOMONADALES, PPAR can: (100% NATURAL CELLULAR FOOD) -REPAIR - AWAKEN -REJUVENATES - ENERGIZES -CLEANSES - LOWER CHOLESTEROL & BLOOD SUGAR -Accelerates healing of inflamed tissues -Strengthens the immune system -Slows down the aging process - Developed and formulated by Dr. Wang Shun Te - Renowned Micro-biologist from Taiwan, 30 years of thoroughly study. "Your HEALTH is our CONCERN" Link to http://meridianlifestyle.blogspot.com for more. Todays Medical Science .. has identified diseases to have originated from the accumulation and collection of toxic wastes in our colon. If not removed regularly, accumulated gunk would paste over the villi, and retards nutrient absorption leading the illnesses. For more details call 7156191 / +639228289128 / +639194827899 . Janet C. Borja YM: anginett888 EMAL: anginettborja@aol.com
Просмотров: 1449 Anginett Catungal
Peter Attia, M.D. on Macronutrient Thresholds for Longevity and Performance, Cancer and More
 
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Dr. Peter Attia is a medical doctor founder of Attia Medical, PC a medical practice with offices in San Diego and New York City, that focuses on the applied science of longevity and optimal performance. In addition to being a medical doctor, Dr. Attia has done research on the role of regulatory T cells in cancer regression and other immune-based therapies for cancer. Regulatory T cells have also been, in the past, referred to as suppressor T cells because of their role in actually attenuating or reducing the inflammatory response. ▶︎ Get the show notes and transcript! https://www.foundmyfitness.com/episodes/peter-attia Links related to Dr. Peter Attia: ▶︎ Visit Dr. Attia's Website: http://www.attiamedical.com/ ▶︎ Dr. Attia on Twitter: https://twitter.com/PeterAttiaMD ▶︎ Dr. Attia on Facebook: https://www.facebook.com/eatingacademy/ Links related to FoundMyFitness: ▶︎ Subscribe on YouTube: https://www.youtube.com/user/FoundMyF... ▶︎ Join my weekly email newsletter: http://www.foundmyfitness.com/?sendme... ▶︎ Crowdfund more videos: http://www.patreon.com/foundmyfitness ▶︎ Subscribe to the podcast: http://itunes.apple.com/us/podcast/fo... ▶︎ Twitter: http://twitter.com/foundmyfitness ▶︎ Facebook: http://www.facebook.com/foundmyfitness ▶︎ Instagram: http://www.instagram.com/foundmyfitness
Просмотров: 128029 FoundMyFitness
ESC TV 2015 - Impact of adipose tissue composition on CV risk assessment in patients with stable CAD
 
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Rapid Fire Abstract - Impact of adipose tissue composition on CV risk assessment in patients with stable CAD Elin Good (Linkoping, Sweden) Ayako Kunimura (Nagoya, Japan) Watch more ESC TV videos on: http://www.escardio.org/esctv
Просмотров: 222 European Society of Cardiology
PTEN and Herceptin Study - Mayo Clinic
 
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Contrary to what many oncologists had thought, a tumor suppressor protein known as PTEN does not reduce the effectiveness of the breast cancer drug Herceptin, according to a study by Mayo Clinic and North Central Cancer Research Group (NCCTG) investigators. "This is the largest study to date evaluating PTEN's presence or loss in the context of antiHER2 therapy, and we found no connection," says the study's lead investigator, oncologist Edith Perez, M.D., director of the Breast Clinic at Mayo Clinic in Jacksonville, Fla., and the Serene M. and Frances C. Durling Professor. "Our research team is very pleased to be able to test an important question in treatment of breast cancer and arrive at a definitive answer." Preclinical studies and some small patient studies had suggested that tumors with loss of PTEN expression would not benefit from Herceptin, Dr. Perez says. As a result, investigators were considering using PTEN biomarkers in clinical studies as a test of Herceptin resistance, and patients who tested positive for PTEN loss might then be offered other therapies, or invited to participate in clinical trials. The researchers presented their findings during the American Society of Clinical Oncology Annual Meeting in Chicago.
Просмотров: 780 Mayo Clinic
Probing nuclear receptor drugs and diseases by MARCOnI
 
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In this presentation, Eric Kalkhoven, PhD, demonstrates how nuclear receptor profiling can play an important role in the identification biomarkers in obesitas.
Просмотров: 304 Pam Gene
Classical and Alternative NF-kappaB Pathways
 
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This animation reviews the classical and alternative NF-kappaB pathways that can be targeted for inhibition. It was presented at an independent satellite symposium "Expert Perspectives in Individualized Treatment of Hematologic Malignancies" at the 2010 ASCO meeting in Chicago, Illinois. Scenes Description. Scene 1: In the classical pathway, incoming stimuli to cell surface receptors initiate a cytoplasmic cascade, beginning with the activation of the IKK-gamma/IKK-alpha/IKK-beta complex. IKK-beta becomes phosphorylated. Scene 2: The IKK complex phosphorylates the IkappaB that is bound to the p50/p65 subunits of NF-kappaB and inhibits its activity. Scene3: Phosphorylated IkappaB undergoes ubiquitinylation followed by proteasomal degradation. This permits NF-kappaB translocation to the nucleus, leading to gene transcription of anti-apoptotic and inflammatory proteins. Scene 4: Bortezomib inhibits proteasomes, preventing the degradation of IkappaB, thereby indirectly inhibiting NF-kappaB transcription activity. Scene 5: In the alternative pathway, extracellular stimuli stimulate cell surface receptors, which leads to the activation of NIK. Scene 6: NIK phosphorylates dimerized IKK-alpha. Scene 7: The RelB/p100 complex is phosphorylated by the IKK-alpha dimer. Scene 8: Upon ubiquitinylation, p100 is cleaved. This yields a RelB/p52 complex which translocates to the nucleus to transcribe proteins related to lymphoid organ development and homeostasis.
Просмотров: 91454 Mechanisms in Medicine
Common Disease Findings
 
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Science Reporters' Seminar on Genome-Wide Association Studies ( http://genome.gov/25521070 ) Francis Collins, M.D., Ph.D. Former Director, National Human Genome Research Institute
Просмотров: 2927 National Human Genome Research Institute
Diabetes Researcher: Family Support - Dody Sears Career Girls Role Model
 
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Dorothy Sears, Ph.D., diabetes researcher at UCSD School of Medicine, shares valuable career guidance and life advice with girls. Watch her full interview at http://www.careergirls.org Welcome to our community! ♥ Website: http://www.careergirls.org ♥ Twitter: https://twitter.com/careergirlsorg ♥ Facebook: https://facebook.com/CareerGirls ♥ Instagram: http://instagram.com/career_girls ♥ Pinterest: http://www.pinterest.com/careergirlsorg/ ♥ CareerGirls Blog: http://www.careergirls.org/community
Просмотров: 25 careergirls
CRYPTO PPARs SINGAPORE |  DR WANG SHUN TE ON LOVE 97.2 Fen Ying |
 
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ROLE OF PPARS THE ROLE OF PPARs IS SIMILAR TO ANTIBIOTICS AND VITAMINS IN THE 20TH CENTURY BUY ONLINE: www.pparsingapore.com BUY CRYPTO PPARs: +65 67348892 Natural algae have existed for more than 300 billion years. It have been studied and recognized by various scientists awarded with Nobel prizes and have been selected as an excellent superfood for astronauts by NASA. They are from Mother Nature and have been studied and improved by distinguished biologists from many countries to become the favorite health food for human beings. Dr. Wang Shun Te with more than 30 years experiences in algae researches has gone through numerous hardships and efforts in order to nurture the most purified and the most precious Cryptomonadales. International Chlorella Biotech Co Ltd (ICBC) is one of Asia's largest microalgae cultivation plant, specialized in the production and technological advancement of microalgae, to increase its many health restoring benefits. We produce organic microalgae free from heavy metals & preservatives with high production standards & premium quality. A biochemical R&D team with the top-notch R&D strength led by Dr. Shun-te. Wang, a biochemical expert with experiences of more than thirty years, not only developed the epoch-making king of algae - Cryptomonadales, but also brought the new idea of green life science and health to the world. GREEN LIFE SCIENCE TEAM : National Health Research Institute of Technology (NHRI) The Industrial Technology Research Institute Biochemical Engineering Research Laboratory (BEL) National Cheng Kung University College of Medicine ABOUT PPARS To compare with Antibiotics and Vitamin in 20 century, there will be a development in medical industry in 21 century which can compare with or even more important. This is the discovery of PPAR molecule. PPAR (peroxisome proliferator activated receptor) is the “nuclear hormone receptor superfamily”. This superfamily can be activated by certain ligand, and it will combine with part of the promoter of the target gene and affect the performance of the gene. There are three states in PPARs family. They are PPAR α, β and γ respectively. These three states have different organization and reflected different physiological functions. Cryptomonadales has been confirmed to contain highly activated agent of PPARs. It is undoubtedly that it will provide important direction regarding the human health in 21 century. The role is similar to Antibiotics and Vitamin in 20 century. BUY CRYPTO PPARs: +65 6734 8892 / +65 8692 6999 EMAIL: ednagoodfinds@gmail.com #ppars #cryptoppars #pparsingapore #ppar #algae #green algae #chlorella #fm97.2 #diabetes #microalgae #superfood #wholefood #cancer #nhf #nhf_singapore #nhf_zhongshan #spirulina
Просмотров: 590 Crypto PPARs Singapore
Cannabinoid receptor 1 internalization
 
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HEK cell co-transfected with DsRed-Clathrin and SEP-CB1 receptor before and after agonist addition. CB1 receptor (green) rapidly clusters into clathrin coated pits (red). Total time = 5 minutes. Imaging was performed using a dual-view under TIRF illumination.
Просмотров: 1449 Theylab
The 2007 Jeffrey M. Trent Lecture in Cancer Research - Eric Lander
 
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October 16, 2007 Lecture Title: Genomic Information The 2007 Jeffrey M. Trent Lectureship in Cancer Research presented by Eric S. Lander, Ph.D., founding director of the Broad Institute of M.I.T. and Harvard. More: http://www.genome.gov/26023567
Просмотров: 10092 National Human Genome Research Institute
adipocyte.AVI
 
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human adipocyte expressing HA-GLUT4-GFP after insulin stimulation
Просмотров: 822 Coritze
Mod-09 Lec-35 Transgenic animals
 
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Eukaryotic Gene Expression:Basics & Benefits by Prof.P N RANGARAJAN,Department of Biochemistry,IISC Bangalore. For more details on NPTEL visit http://nptel.iitm.ac.in
Просмотров: 8622 nptelhrd
Abdominal Fat Accumulation in HIV: Interview with Dr Grinspoon
 
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Nelson Vergel from PowerUSA.org interviews Dr Steven Grinspoon from Havard Medical School about what we know about HIV lipodystrophy associated fat accumulation. Dr Grinspoon covers potential causes and treatments. For more information please refer to the closing image at the end of the video. QUESTIONS FOR DR GRINSPOON’S INTERVIEW: 1. Please give our audience background information on what HIV lipodystrophy is. 2. What causes HIV lipodystrophy? How is HIV lipodystrophy different than other lipodystrophies? 3. What types of fat tissue does the body have? What are their metabolic functions, if any? 4. Why is visceral fat and dorsocervical accumulation not just a cosmetic issue? 5. Talking specifically about visceral fat (VAT), have we learned about what makes someone more or less prone to having increased VAT before and after starting antiretrovirals? Is increased VAT driven by HIV as much as ART? Inflammation? 6. Are some antiretrovirals “better” than others when it comes to avoiding excessive VAT increase? Can switching HIV regimens improve VAT? 7. What kind of hormonal, lipids and glucose issues have you seen in your research with HIV+ patients experiencing increased VAT? 8. What is growth hormone pulsatile release and how does it differ in HIV lipodystrophy patients? 9. Are there any ways to predict who may have more increased VAT when starting HIV ARVs? 10. VAT then and now- Is increased VAT as common now as it was back in the 90’s and early 2000’s? If not, why? is current lipodystrophy being hidden by the aging of the HIV population? Is our perception of a decrease in prevalence being affected by the increase of fat tissue due to aging? Does current day LD look different and how? 11. What treatments are approved to manage adipose tissue accumulation in HIV? How effective is it? 12. How can we predict if someone will be a good responder to the therapy? When someone responds what should they expect? Does something happen metabolically before the response happens? 13. Can exercise and diet work in synergy with the adipose tissue treatment? How about any synergy with Metformin? 14. How does liver fat affect someone’s health? Do we experience more liver fat in HIV lipodystrophy? 15. Can you tell us how VAT can affect carotid intima thickness, coronary calcium, hypertension, neurocognitive, and mortality? 16. Follow up, will a reduction in VAT improve these? What about SAT? 17. Why has leptin not been studied further? 18. Your team recently published a puzzling study on DICER deficiency in HIV lipodystrophy patients. Can you elaborate on your findings and what they may mean clinically? 19. Why does it seem that a lot of the HIV lipodystrophy research interest has decreased in the last few years? What can patient advocates do to advance more research? DOWNLOAD TRANSCRIPT: http://img.thebody.com/thebody/2016/grinspoon_interview.pdf
Просмотров: 71322 Program for Wellness Restoration
Cystic Mass and Gall Stones - 3 week taking CRYPTOMONADALES
 
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Know more about the benefit of taking CRYPTOMONADALES AND CLEANSE. LINK TO: http://meridianlifestyle.blogspot.com Also known as Chorella Sorokiniana, cryptomonadales is a complete food that has macro, micro and trace nutrients together with essential amino acids and enzymes critical for optimal health, Crypto+ contains 100% cryptomonadales, which is a plant containing chlorophyll, vitamins and high levels of protein. When applied in medication, Cryptomonadales have been used to cure or alleviate many kinds of chronic diseases, including cancer, anemia, lupus, sterility and so on in order to gain scientific proof. It boosts immunity or immune system. It reduces cholesterol (blood fat) and enhances hematopoieis. It lowers the acidity level of the body. It has detoxification capabilities. It activates protein synthesis. It normalizes the metabolism of lipids. It regulates metabolism, and ensures that carbohydrates are converted into energy (ATP). It enhances our natural immunity by activating T-lymphocytes cells such as phagocytes, which kill bacteria and viruses. It enhances the production of Natural Killer (NK) cells, which kill cancer cells. It renews, rejuvenates, and revitalizes our cells, and thus boosts overall health and well-being. It is the only known algae in the world containing significant amounts of all three naturally occurring Alpha, Beta, and Gamma PPARs. It also contains generous amounts of chlorophyll (a blood cleanser, aids in blood formation, helps to balance pH and thus is important for cancer prevention) and CGF (Cell Growth Factor--has highest known levels of nucleic acids) and phycocyanin (with anti-oxidant and anti-viral properties). JANET C. BORJA +639194827899 / +639228289128 EMAIL: anginett888@yahoo.com YM: anginett888
Просмотров: 1844 Anginett Catungal
Insulin Signaling (Signal Pathways)
 
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NDSU Virtual Cell Animations Project animation 'Insulin Signaling'. For more information please see http://vcell.ndsu.edu/animations. When high levels of glucose enter the blood stream, insulin is released by beta cells in the pancreas. Insulin then initiates a number of signal pathways in specific muscle and fat cells. This takes a look at the signal pathway responsible for allowing those cells to rapidly increase their ability to uptake glucose from the blood stream.
Просмотров: 256152 ndsuvirtualcell
Unboxing Crypto Ppars Liquid Extract Plus | 引藻精 | Crypto Ppars Singapore
 
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Crypto Ppars Liquid Extract Plus 10 vials in a box Learn more about crypto Ppars at: www.edvolution69.com A special extract that holds the amount of potency as high as 1000 tablets (per vial) Crypto extract liquid plus is meant for those whom are in critical needs and for anti-aging purposes. ABOUT PPARS To compare with Antibiotics and Vitamin in 20 century, there will be a development in medical industry in 21 century which can compare with or even more important. This is the discovery of PPAR molecule. PPAR (peroxisome proliferator activated receptor) is the “nuclear hormone receptor superfamily”. This superfamily can be activated by certain ligand, and it will combine with part of the promoter of the target gene and affect the performance of the gene. There are three states in PPARs family. They are PPAR α, β and γ respectively. These three states have different organization and reflected different physiological functions. Cryptomonadales has been confirmed to contain highly activated agent of PPARs. It is undoubtedly that it will provide important direction regarding the human health in 21 century. The role is similar to Antibiotics and Vitamin in 20 century. PPARS - NATURAL GENE ACTIVATORS Abundance in antioxidants, vitamins, proteins, fatty acids and phytominerals, the PPAR Activators enable your biological functions & systems to perform at optimum levels & achieve homeostasis. Subscribe to our channel for more natural health solutions! Website: http://www.edvolution69.com Facebook: http://www.facebook.com/edvolution69 Pinterest: http://www.pinterest.com/edvolution69 Twitter: http://www.twitter.com/edvolution69 #ppars #cryptoppars #pparsingapore #ppar #algae #green algae #chlorella #fm97.2 #diabetes #microalgae #superfood #wholefood #cancer #nhf #nhf_singapore #nhf_zhongshan #spirulina Disclaimer: The Info in this video is NOT intended to replace with a qualified health professional and is not intended as medical advise.
Просмотров: 58 Edvolution 69
TCGA: Papillary Thyroid Carcinoma Analysis - Thomas Giordano
 
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November 27-28, 2012 - The Cancer Genome Atlas' 2nd Annual Scientific Symposium: Enabling Cancer Research Through TCGA More: http://www.genome.gov/27551851
Просмотров: 1626 National Human Genome Research Institute
USMLE GIT 15: Diabetes Pathophysiology and Pharmacology Pt.2
 
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Welcome to LY Med, where I go over everything you need to know for the USMLE STEP 1, with new videos every day. Follow along with First Aid, or with my notes which can be found here: https://www.dropbox.com/sh/m55dzy5jjuahmav/AABZGpqvdSytIuEmxIjyt5V0a?dl=0 Continuing our talk on the pathophysiology and pharmacology of diabetes. There are two types of diabetes. The first type is due to autoimmune destruction of your islet cells! Type 2 is due to insulin resistance. Labs include fasting blood glucose, HbA1c, and glucose tolerance testing. Now how does high blood sugar cause heart attacks, nephropathy, neuropathy, retinopathy etc? Well some mechanisms include osmotic damage, as well as non-enzymatic glycosylation. This is when sugar just latches on to your blood vessels and nerves and damages them. Now acute complications of extremely high blood sugar include diabetic ketoacidosis or Hyperosmolar hyperglycemic state. The difference between the two is whether or not you have normal glucagon. In DKA, you have high blood sugar and HIGH glucagon. Glucagon breaks down your body's glucagon and fat. This leads to ketone bodies, ketosis, Kussmaul breathing. Labs will show metabolic acidosis and hyperkalemia. Complications include coma, death, and Mucormycosis. Meanwhile, in HHS, you have high sugar but NORMAL glucagon. Due to the normal glucagon, you don't have ketosis. Lastly we can finally talk about drugs and pharm of diabetes. In type 1 DM, we treat it with insulin. You should know all the different types of insulin and how quickly they work. Type 2 DM is first treated with diet and exercise. Second line is oral drugs. Drugs include: A-glucosidase inhibitors: inhibit brush border glucosidase which helps lower the reabsorption of sugar. Sulfonylureas and Meglitinide: closes the potassium channel in beta cells. GLP1 mimetics, DDP4 inhibitors, and amylin analogs. Biguanides like metformin: decrease gluconeogenesis and act as a sensitizing agent. Side effects include lactic acidosis. Thiazolidenidones: these bind to PPAR-gamma, and increase GLUT 4 synthesis. Side effect is exacerbation of heart failure. SLGT2 inhibitors: block reabsorption of glucose in PCT. Side effects include UTIs.
Просмотров: 453 LY Med
Crypto PPARs Singapore | Unravelling The Mystery Of DNA REPAIR | Dr Thomas Carell
 
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CRYPTO PPARS SINGAPORE DISTRIBUTOR BUY ONLINE: www.pparsingapore.com CALL : +65 6734 8892 / +65 91019230 EVIDENCE OF THE SECRETS OF DNA REPAIR | Sponsored by Bayers International The inside of a cell, the nucleus, contains the construction plan for life. DNA, which forms the basis of all life functions. Our genetic material is under constant attack from viruses, environmental factors & bacteria. As a result, the DNA in each cell is damage 40,000 times per day. Its a problem that human share with animals and plants. Yet, in spite of this, most organism survived. This scientist had discovered why - The winner of the 2008 Auto Bayer Prize, Professor Thomas Carell, a chemist at Ludwig Maximulians University in Munich. He put together a 30 strong team of scientist from different disciplines. Until then, scientists had only found out that proteins were involved in the repair process in some form. But nobody knows how the repair teams bind the proteins to the DNA nor how they identify damage. - Major Damage! Carell team had overcome all obstacles and had achieve his objective. The repair enzymes first bend & twist the DNA around its own axis around the sides of the damage. The researchers discover a minor sensation there. Its a blue spectrum of daylight that provides the previously unexplained burst of energy to initiate the process capable of repairing the even major DNA damage in a billion of a second! An understanding of these processes could open up new medical possibilities leading to better treatment of cancers, for example. In early 2008, Professor Thomas Carell was awarded the Auto Bayer Prize with $50,000 Euros for his research activities at a ceremony in Berlin. EMAIL : ednagoodfinds@gmail.com F B : pparsingapore
Просмотров: 369 Crypto PPARs Singapore
Francis Collins speaking at the Genbank 25th Anniversary
 
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Francis Collins Director, National Human Genome Research Institute (NHGRI), NIH, Bethesda, MD Genomics, Medicine and Society Slides available: http://www.ncbi.nlm.nih.gov/About/genbank25/data/day2/collins/index.html
Просмотров: 6817 NCBI
Sugar and the beating heart: the conundrum of heart failure in diabetes
 
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Sugar and the beating heart: the conundrum of heart failure in diabetes Air date: Wednesday, February 7, 2018, 3:00:00 PM Category: WALS - Wednesday Afternoon Lectures Runtime: 01:02:50 Description: NIH Director’s Wednesday Afternoon Lecture Series Dr. Abel is internationally recognized for his research on the molecular mechanisms responsible for cardiac dysfunction in obesity, type 2 diabetes, and type 1 diabetes, and for studies of the role of mitochondrial dysfunction in the development of insulin resistance, obesity, and its complications. Dr. Abel earned his medical degree with distinction from the University of the West Indies in Kingston, Jamaica. He was a Rhodes Scholar and clinical research fellow with Professor John G. Ledingham at the University of Oxford, England, where he also earned a Ph.D. in physiology. He completed an internship and residency in medicine at McGraw Medical Center, a part of Northwestern University Medical School, where he served as chief resident of internal medicine at the VA Lakeside Medical Center. He was a clinical and research fellow and instructor at Harvard Medical School before joining the faculty at the University of Utah in 2000. Dr. Abel has earned many awards including the Van Meter Prize of the American Thyroid Association in 2001 and the 2012 Gerald D. Aurbach Award, from The Endocrine Society for "outstanding" contributions to endocrine research. He was elected Chair of the Board of Scientific Counselors of the NIH National Institute of Diabetes and Digestive and Kidney Diseases, and now serves as a member of the advisory council of the National Heart, Lung, and Blood Institute. He was chair of the Sarnoff Cardiovascular Research Foundation's Scientific Committee from 2012 to 2013, and is a fellow of the American Heart Association and the American College of Physicians. He was recently elected as president of the Endocrine Society. Dr. Abel is an elected member of the American Society for Clinical Investigation, American Clinical and Climatological Association, and the Association of American Physicians. He was elected to the National Academy of Medicine in October 2015. For more information go to https://oir.nih.gov/wals/2017-2018/sugar-beating-heart-conundrum-heart-failure-diabetes Author: E. Dale Abel, M.D., Ph.D., Francois M. Abboud Chair in Internal Medicine and John B. Stokes Chair in Diabetes Research; Chair and Department Executive Officer, Department of Internal Medicine, University of Iowa, Carver College of Medicine Permanent link: https://videocast.nih.gov/launch.asp?23703
Просмотров: 581 nihvcast
Mutation
 
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In genetics, a mutation is a change of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal genetic element. Mutations result from unrepaired damage to DNA or to RNA genomes , errors in the process of replication, or from the insertion or deletion of segments of DNA by mobile genetic elements. Mutations may or may not produce discernible changes in the observable characteristics of an organism. Mutations play a part in both normal and abnormal biological processes including: evolution, cancer, and the development of the immune system. This video targeted to blind users. Attribution: Article text available under CC-BY-SA Public domain image source in video
Просмотров: 544 encyclopediacc
GM5: ACMG Guidelines for Incidental Findings - Leslie Biesecker
 
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May 28-29, 2013 - Genomic Medicine Centers Meeting V: Working With Federal Stakeholders. More: http://www.genome.gov/27553865
Просмотров: 336 National Human Genome Research Institute
Genome-Wide Association Studies - Karen Mohlke (2012)
 
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March 14, 2012 - Current Topics in Genome Analysis 2012 More: http://www.genome.gov/COURSE2012
Просмотров: 34329 National Human Genome Research Institute
Mass Effect Andromeda - Romance avec Suvi Anwar
 
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Retrouvez l'actualité de Mass Effect Andromeda sur http://masseffectuniverse.fr/
Просмотров: 1954 MassEffectUniverseFR
NINR Symptom Science Research Symposium
 
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On April 25, 2017, the NINR Intramural Research Program convened a scientific symposium, Symptom Science Research: A Path to Precision Health, on the NIH campus in Bethesda, Maryland, highlighting Intramural’s scientific advances and collaborations across the National Institutes of Health and other organizations.
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Chronic Hazard Advisory Panel: Phthalates AM Session
 
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Original broadcast date: July 26, 2010
Просмотров: 58 U.S. Consumer Product Safety Commission
Chronic Hazard Advisory Panel: Phthalates Afternoon Session
 
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Original broadcast date: July 27, 2010
Просмотров: 42 U.S. Consumer Product Safety Commission