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Role of PPARγ in HCC – Video abstract 48512
 
03:44
Video abstract of a review paper “Emerging role of the peroxisome proliferator-activated receptor-gamma in hepatocellular carcinoma” published in the open access Journal of Hepatocellular Carcinoma by Hsu HT and Chi CW. Abstract: Hepatocellular carcinoma (HCC) is the major leading cause of cancer death worldwide. Hepatitis B virus, hepatitis C virus, alcohol consumption, non-alcoholic fatty liver disease, and diabetes are the major risks for developing HCC. Until now, recurrence and metastasis are the major cause of death in HCC patients. Therefore, identification of new effective molecular targets is an urgent need for treatment of HCC. Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated nuclear receptor which could be activated by PPARγ agonists such as thiazolidinediones, and natural PPARγ ligand (such as 15-deoxy-Δ12,14-prostaglandin J2, 15d-PGJ2). Increasing in vitro and in vivo evidence has demonstrated that PPARγ agonists exhibit an inhibitory role on tumor cell growth, migration, and invasion, suggesting that PPARγ activation may play an important role in the regulation of growth of HCC. It has been reported that PPARγ activation by thiazolidinediones or overexpression of PPARγ by virus-mediated gene transfer has shown growth inhibitory effects in hepatoma cells, but the expression level of PPARγ in HCC tissues still remains conflicting. Notably, a novel PPARγ agonist, honokiol, has recently been found to activate the PPARγ/RXR heterodimer, and has also exhibited significant anti-cancer effects in hepatoma cells. In the present review, we summarized studies on the role and the molecular regulation of PPARγ in HCC development in vitro and in vivo. PPARγ has the potential to be a therapeutic target for future treatment of HCC. Read the full paper here: http://www.dovepress.com/emerging-role-of-the-peroxisome-proliferator-activated-receptor-gamma--peer-reviewed-article-JHC
Просмотров: 460 Dove Medical Press
PPARs - LIVE BLOOD ANALYSIS
 
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Recognized by medical researchers as "the most important bio-molecular discovery" in the 21st century, PPARs represent the best supplement available for your cellular health. It is also hailed as one of the most promising leads into the area of anti-aging research. In a study conducted by the Division of Biotechnology and Pharmaceutics, National Health Research Institutes, Taiwan, Cryptomonadales is the only known algae in the world containing significant amounts of all three naturally occurring Alpha, Beta, and Gamma PPARs. Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor super family of ligand-activated transcription factors that are related to retinoid, steroid and thyroid hormone receptors. PPARs play an important role in many cellular functions including lipid metabolism, cell proliferation, differentiation, adipogenesis and inflammatory signalling. PPARα helps in Liver, heart and bones PPARβ/δhelps in Skin, bone, muscles PPARγ helps in Lipid, Colon and other organs. All 3 isoforms of PPARs: helps in blood system and immune system. The 3 isoforms of alpha, beta and gamma can potentially help lipid metabolism, glucose homeostasis, anti-inflammation, immunoregulation and cell differentiation (cancer). It has shown major breakthrough to treat metabolism syndrome (diabetes mellitus, obesity, hyper-cholesterolemia and hypertension) and improve control of cardiovascular diseases like stroke and myocardial infarction. http://cryptomonadalesppar.wordpress.com htt://meridianlifestyle.blogspot.com JANET C. BORJA +639228289128 / +639194827899 EMAIL: anginett@gmail.com YM: anginett888 SKYPE: janetborja
Просмотров: 2559 Anginett Catungal
Proxim-A International Incorporated Ppars in Cancer Treatment
 
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PROXIM-A PPAR's Peroxisome Proliferator Activated Receptors ( PPARs ) * Members of Nuclear Hormone Receptor Superfamily * It Helps For the Treatment and Prevention of Diseases • Anti-Ageing ( Stay Young Looking ) • Growth Booster ( Height Gain for Children ) • Repair Cells • Skin Problems • Diabetes • Obesity • Eczema • Asthma • Vertigo • Hyperthyroidism • Kidney Problems • Heart Disease • Lungs Disease • Liver Problems • Bones Problem • Hypertension • Cancer The peroxisome Proliferator Activated Receptors ( PPARs ) are nuclear fatty acid receptors that have been implicated to play crucial roles in metabolic diseases such as hyperlipidemia, insulin, resistance, and diabetes. The three PPAR subtypes, alpha, gamma, and delta, have distinct expression patterns and regulate glucose homeostasis based on the need of a specific tissue. While PPAR alpha potentiates fatty acid catabolism in the liver and is the molecular target of the lipid-lowering fibrates, PPAR gamma is essential for adipocyte differentation and hypertrophy, and mediates the activity of the insulin sensitizing thiazolidinediones. PPAR delta may be important in regulating body weight and lipid metabolism in fat tissues. Thus, uncovering the regulatory mechanisms and transcriptional targets of these PPARs will provide insights into the pathogenesis of metabolic diseases and offer valuable information for rational drug design. Order Now Contact Loyd 09975793732
Просмотров: 44 abundant Universe
PPARs - CRYPTOMONADALES
 
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PubMed U.S. National Library of Medicine National Institutes of Health [PPAR and diabetes]. [Article in Japanese] Terauchi Y, Kadowaki T. Source Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo. Abstract The peroxisome proliferator-activated receptors (PPARs) are nuclear fatty acid receptors that have been implicated to play crucial roles in metabolic diseases such as hyperlipidemia, insulin resistance, and diabetes. The three PPAR subtypes, alpha, gamma, and delta, have distinct expression patterns and regulate glucose homeostasis based on the need of a specific tissue. While PPARalpha potentiates fatty acid catabolism in the liver and is the molecular target of the lipid-lowering fibrates, PPARgamma is essential for adipocyte differentiation and hypertrophy, and mediates the activity of the insulin sensitizing thiazolidinediones. PPARdelta may be important in regulating body weight and lipid metabolism in fat tissues. Thus, uncovering the regulatory mechanisms and transcriptional targets of these PPARs will provide insights into the pathogenesis of metabolic diseases and offer valuable information for rational drug design. JANET C. BORJA +639228289128 / +639194827899 EMAIL: anginett@gmail.com YM: anginett888 WEBSITE: http://janetborja.com http://cryptomonadalesppar.wordpress.com http://meridianlifestyle.blogspot.com
Просмотров: 13924 Anginett Catungal
Targeting the cell cycle in cancer: Aurora kinase inhibition
 
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Mechanism of action of a new strategy to fight cancer: the inhibition of the cell cycle through Aurora Kinase inhibition. Mécanisme d'action d'une nouvelle stratégie thérapeutique pour lutter contre le cancer: l'inhibition du cycle cellulaire via une action ciblée sur l'Aurora Kinase. Association website: http://www.efp-online.fr Online education: http://www.invivoveritas.fr
Просмотров: 10015 AssoEFP
Peter Attia, M.D. on Macronutrient Thresholds for Longevity and Performance, Cancer and More
 
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Dr. Peter Attia is a medical doctor founder of Attia Medical, PC a medical practice with offices in San Diego and New York City, that focuses on the applied science of longevity and optimal performance. In addition to being a medical doctor, Dr. Attia has done research on the role of regulatory T cells in cancer regression and other immune-based therapies for cancer. Regulatory T cells have also been, in the past, referred to as suppressor T cells because of their role in actually attenuating or reducing the inflammatory response. ▶︎ Get the show notes and transcript! https://www.foundmyfitness.com/episodes/peter-attia Links related to Dr. Peter Attia: ▶︎ Visit Dr. Attia's Website: http://www.attiamedical.com/ ▶︎ Dr. Attia on Twitter: https://twitter.com/PeterAttiaMD ▶︎ Dr. Attia on Facebook: https://www.facebook.com/eatingacademy/ Links related to FoundMyFitness: ▶︎ Subscribe on YouTube: https://www.youtube.com/user/FoundMyF... ▶︎ Join my weekly email newsletter: http://www.foundmyfitness.com/?sendme... ▶︎ Crowdfund more videos: http://www.patreon.com/foundmyfitness ▶︎ Subscribe to the podcast: http://itunes.apple.com/us/podcast/fo... ▶︎ Twitter: http://twitter.com/foundmyfitness ▶︎ Facebook: http://www.facebook.com/foundmyfitness ▶︎ Instagram: http://www.instagram.com/foundmyfitness
Просмотров: 156864 FoundMyFitness
How PPAR delta receptor is resulting in the burning of fat
 
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The PPAR-delta receptor activates certain genes in a muscle cell, resulting in the burning of fat. PPAR-delta is one of a family of receptors that is related to the metabolism and storing of fat. Like PPAR-gamma, it also activates certain genes. However, PPAR-delta's activation signals the muscle cell to burn fat for energy. This led to the creation of a PPAR-delta-activated mouse, which can run significantly longer distances than regular mice, and which are more resistant to obesity. www.pparscancer.com
Просмотров: 5439 Kevin Nga
CRYPTOMONADALES - PPARs
 
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Recognized by medical researchers as the most important bio-molecular discovery in the 21st century, PPARs represent the best supplement available for your cellular health. It is also hailed as one of the most promising leads into the area of anti-aging research. In a study conducted by the Division of Biotechnology and Pharmaceutics, National Health Research Institutes, Taiwan, Cryptomonadales is the only known algae in the world containing significant amounts of all three naturally occurring Alpha, Beta, and Gamma PPARs. Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor super family of ligand-activated transcription factors that are related to retinoid, steroid and thyroid hormone receptors. PPARs play an important role in many cellular functions including lipid metabolism, cell proliferation, differentiation, adipogenesis and inflammatory signalling. PPARα helps in Liver, heart and bones PPARβ/δhelps in Skin, bone, muscles PPARγ helps in Lipid, Colon and other organs. All 3 isoforms of PPARs: helps in blood system and immune system. The 3 isoforms of alpha, beta and gamma can potentially help lipid metabolism, glucose homeostasis, anti-inflammation, immunoregulation and cell differentiation (cancer). It has shown major breakthrough to treat metabolism syndrome (diabetes mellitus, obesity, hyper-cholesterolemia and hypertension) and improve control of cardiovascular diseases like stroke and myocardial infarction. Cryptomonadales PPAR 12 g (Pictures) Concentrated extraction of CGF and PPAR of Cryptomonadales
Просмотров: 11384 Anginett Catungal
Mod-09 Lec-35 Transgenic animals
 
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Eukaryotic Gene Expression:Basics & Benefits by Prof.P N RANGARAJAN,Department of Biochemistry,IISC Bangalore. For more details on NPTEL visit http://nptel.iitm.ac.in
Просмотров: 8853 nptelhrd
Probing nuclear receptor drugs and diseases by MARCOnI
 
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In this presentation, Eric Kalkhoven, PhD, demonstrates how nuclear receptor profiling can play an important role in the identification biomarkers in obesitas.
Просмотров: 307 Pam Gene
Common Disease Findings
 
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Science Reporters' Seminar on Genome-Wide Association Studies ( http://genome.gov/25521070 ) Francis Collins, M.D., Ph.D. Former Director, National Human Genome Research Institute
Просмотров: 2928 National Human Genome Research Institute
Dr. Georgia Ede - 'Our Descent into Madness: Modern Diets and the Global Mental Health Crisis'
 
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Dr. Georgia Ede received her B.A. in Biology from Carleton College in Minnesota, then spent seven years as a research assistant in the fields of biochemistry, wound healing, and diabetes before going on to earn an M.D. from the University of Vermont College Of Medicine. Dr. Ede then completed her residency in general adult psychiatry at Harvard's Cambridge Hospital in 2002 and was a staff psychopharmacologist at Harvard University Health Services from 2007 to 2013. In 2013 she left Harvard to become the psychiatrist for Smith College in Northampton, Massachusetts, where she provides nutrition consults as well as psychiatric services to Smith students. Dr. Ede was the first and only psychiatrist at Harvard University Health Services to offer nutrition consultation as an alternative to medication management to students, faculty and staff. Her areas of expertise include ketogenic and pre-agricultural diets, food sensitivity syndromes, and college mental health. She explores food’s powerful effects on brain chemistry, hormonal balance and metabolism for Psychology Today and on her website www.DiagnosisDiet.com.
Просмотров: 74422 Low Carb Down Under
TCGA: Papillary Thyroid Carcinoma Analysis - Thomas Giordano
 
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November 27-28, 2012 - The Cancer Genome Atlas' 2nd Annual Scientific Symposium: Enabling Cancer Research Through TCGA More: http://www.genome.gov/27551851
Просмотров: 1643 National Human Genome Research Institute
Unboxing Crypto Ppars Liquid Extract Plus | 引藻精 | Crypto Ppars Singapore
 
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Crypto Ppars Liquid Extract Plus 10 vials in a box Learn more about crypto Ppars at: www.edvolution69.com A special extract that holds the amount of potency as high as 1000 tablets (per vial) Crypto extract liquid plus is meant for those whom are in critical needs and for anti-aging purposes. ABOUT PPARS To compare with Antibiotics and Vitamin in 20 century, there will be a development in medical industry in 21 century which can compare with or even more important. This is the discovery of PPAR molecule. PPAR (peroxisome proliferator activated receptor) is the “nuclear hormone receptor superfamily”. This superfamily can be activated by certain ligand, and it will combine with part of the promoter of the target gene and affect the performance of the gene. There are three states in PPARs family. They are PPAR α, β and γ respectively. These three states have different organization and reflected different physiological functions. Cryptomonadales has been confirmed to contain highly activated agent of PPARs. It is undoubtedly that it will provide important direction regarding the human health in 21 century. The role is similar to Antibiotics and Vitamin in 20 century. PPARS - NATURAL GENE ACTIVATORS Abundance in antioxidants, vitamins, proteins, fatty acids and phytominerals, the PPAR Activators enable your biological functions & systems to perform at optimum levels & achieve homeostasis. Subscribe to our channel for more natural health solutions! Website: http://www.edvolution69.com Facebook: http://www.facebook.com/edvolution69 Pinterest: http://www.pinterest.com/edvolution69 Twitter: http://www.twitter.com/edvolution69 #ppars #cryptoppars #pparsingapore #ppar #algae #green algae #chlorella #fm97.2 #diabetes #microalgae #superfood #wholefood #cancer #nhf #nhf_singapore #nhf_zhongshan #spirulina Disclaimer: The Info in this video is NOT intended to replace with a qualified health professional and is not intended as medical advise.
Просмотров: 88 Edvolution 69
Abdominal Fat Accumulation in HIV: Interview with Dr Grinspoon
 
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Nelson Vergel from PowerUSA.org interviews Dr Steven Grinspoon from Havard Medical School about what we know about HIV lipodystrophy associated fat accumulation. Dr Grinspoon covers potential causes and treatments. For more information please refer to the closing image at the end of the video. QUESTIONS FOR DR GRINSPOON’S INTERVIEW: 1. Please give our audience background information on what HIV lipodystrophy is. 2. What causes HIV lipodystrophy? How is HIV lipodystrophy different than other lipodystrophies? 3. What types of fat tissue does the body have? What are their metabolic functions, if any? 4. Why is visceral fat and dorsocervical accumulation not just a cosmetic issue? 5. Talking specifically about visceral fat (VAT), have we learned about what makes someone more or less prone to having increased VAT before and after starting antiretrovirals? Is increased VAT driven by HIV as much as ART? Inflammation? 6. Are some antiretrovirals “better” than others when it comes to avoiding excessive VAT increase? Can switching HIV regimens improve VAT? 7. What kind of hormonal, lipids and glucose issues have you seen in your research with HIV+ patients experiencing increased VAT? 8. What is growth hormone pulsatile release and how does it differ in HIV lipodystrophy patients? 9. Are there any ways to predict who may have more increased VAT when starting HIV ARVs? 10. VAT then and now- Is increased VAT as common now as it was back in the 90’s and early 2000’s? If not, why? is current lipodystrophy being hidden by the aging of the HIV population? Is our perception of a decrease in prevalence being affected by the increase of fat tissue due to aging? Does current day LD look different and how? 11. What treatments are approved to manage adipose tissue accumulation in HIV? How effective is it? 12. How can we predict if someone will be a good responder to the therapy? When someone responds what should they expect? Does something happen metabolically before the response happens? 13. Can exercise and diet work in synergy with the adipose tissue treatment? How about any synergy with Metformin? 14. How does liver fat affect someone’s health? Do we experience more liver fat in HIV lipodystrophy? 15. Can you tell us how VAT can affect carotid intima thickness, coronary calcium, hypertension, neurocognitive, and mortality? 16. Follow up, will a reduction in VAT improve these? What about SAT? 17. Why has leptin not been studied further? 18. Your team recently published a puzzling study on DICER deficiency in HIV lipodystrophy patients. Can you elaborate on your findings and what they may mean clinically? 19. Why does it seem that a lot of the HIV lipodystrophy research interest has decreased in the last few years? What can patient advocates do to advance more research? DOWNLOAD TRANSCRIPT: http://img.thebody.com/thebody/2016/grinspoon_interview.pdf
Просмотров: 71591 Program for Wellness Restoration
The 2007 Jeffrey M. Trent Lecture in Cancer Research - Eric Lander
 
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October 16, 2007 Lecture Title: Genomic Information The 2007 Jeffrey M. Trent Lectureship in Cancer Research presented by Eric S. Lander, Ph.D., founding director of the Broad Institute of M.I.T. and Harvard. More: http://www.genome.gov/26023567
Просмотров: 10118 National Human Genome Research Institute
Genome-Wide Association Studies - Karen Mohlke (2012)
 
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March 14, 2012 - Current Topics in Genome Analysis 2012 More: http://www.genome.gov/COURSE2012
Просмотров: 35926 National Human Genome Research Institute
Sugar and the beating heart: the conundrum of heart failure in diabetes
 
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Sugar and the beating heart: the conundrum of heart failure in diabetes Air date: Wednesday, February 7, 2018, 3:00:00 PM Category: WALS - Wednesday Afternoon Lectures Runtime: 01:02:50 Description: NIH Director’s Wednesday Afternoon Lecture Series Dr. Abel is internationally recognized for his research on the molecular mechanisms responsible for cardiac dysfunction in obesity, type 2 diabetes, and type 1 diabetes, and for studies of the role of mitochondrial dysfunction in the development of insulin resistance, obesity, and its complications. Dr. Abel earned his medical degree with distinction from the University of the West Indies in Kingston, Jamaica. He was a Rhodes Scholar and clinical research fellow with Professor John G. Ledingham at the University of Oxford, England, where he also earned a Ph.D. in physiology. He completed an internship and residency in medicine at McGraw Medical Center, a part of Northwestern University Medical School, where he served as chief resident of internal medicine at the VA Lakeside Medical Center. He was a clinical and research fellow and instructor at Harvard Medical School before joining the faculty at the University of Utah in 2000. Dr. Abel has earned many awards including the Van Meter Prize of the American Thyroid Association in 2001 and the 2012 Gerald D. Aurbach Award, from The Endocrine Society for "outstanding" contributions to endocrine research. He was elected Chair of the Board of Scientific Counselors of the NIH National Institute of Diabetes and Digestive and Kidney Diseases, and now serves as a member of the advisory council of the National Heart, Lung, and Blood Institute. He was chair of the Sarnoff Cardiovascular Research Foundation's Scientific Committee from 2012 to 2013, and is a fellow of the American Heart Association and the American College of Physicians. He was recently elected as president of the Endocrine Society. Dr. Abel is an elected member of the American Society for Clinical Investigation, American Clinical and Climatological Association, and the Association of American Physicians. He was elected to the National Academy of Medicine in October 2015. For more information go to https://oir.nih.gov/wals/2017-2018/sugar-beating-heart-conundrum-heart-failure-diabetes Author: E. Dale Abel, M.D., Ph.D., Francois M. Abboud Chair in Internal Medicine and John B. Stokes Chair in Diabetes Research; Chair and Department Executive Officer, Department of Internal Medicine, University of Iowa, Carver College of Medicine Permanent link: https://videocast.nih.gov/launch.asp?23703
Просмотров: 705 nihvcast
Effect of senescence on bone remodelling: the role of inflammageing - Lia Ginaldi
 
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Osteoporosis is a major cause of morbidity and mortality in older people. Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue with a subsequent increase in bone fragility and susceptibility to fractures. There are a large number of risk factors for the development of senile osteoporosis. However, recent discoveries suggest that inflammageing, i.e. the immunological inflammatory profile characterizing immune senescence, plays a major role in bone remodelling through pro-inflammatory cytokines, which are able to influence osteoclasts and osteoblasts. Therefore ageing induces osteoporosis through immunologically mediated modulation of bone remodelling. It is the activated immune profile which, through inflammation and inflammatory cytokine production, modulates osteoblast and osteoclast activity leading to osteoporosis. Senile osteoporosis is an example of the central role of immune-mediated inflammation in determining bone resorption. Here we discuss the pathogenesis of osteoporosis in the context of immunosenescence and focus on therapeutic strategies targeting osteoimmunology pathways. Osteoimmunology is an emerging research area that deals with the mutual interactions between bone and the immune system. Osteoclast, the sole resorbing bone cell, is the center of attention in osteoimmunological research, due to its haematopoietic origin and strong activation through cytokines. However, novel functions of osteoblasts, specialized in bone formation, and osteocytes, the structural bone cells, have also been recently unraveled. Critical proteins with osteoimmune functions, including the pro-osteoclastic cytokine receptor activator of NF-ĸB ligand and inhibitors of the pro-osteoblastic Wnt signaling pathway, recently showed roles of paramount importance in both inflammageing and osteoporosis. The combined effects of estrogen deprivation and raising of FSH production occurring in menopause cause a marked stimulation of bone resorption and a rapid bone loss which is central for the onset of postmenopausal osteoporosis and chronic inflammatory diseases. These discoveries have also led to the development of targeted therapies to counteract not only inflammation-induced bone loss but also postmenopausal and senile osteoporosis. Ageing also affects bone through the production of myeloid cells in bone marrow, a condition associated with increased chronic inflammation by macrophages and decreased bone mass due to excess bone resorption by osteoclasts. The ageing of both haematopoietic stem cells and bone marrow microenvironment, emerging from increased oxidative stress, peroxisome proliferator-activated receptor γ activity and adipogenesis in the ageing bone marrow, contribute to impaired osteoblastogenesis and niche cell function. Anti-ageing interventions targeting mesenchymal stem cell differentiation in the bone marrow could enhance osteoblastic bone formation and counteract inflammation and osteoclastic bone loss. The inducer cells in senile osteoporosis are immune cells, such as activated macrophages and lymphocytes, which produce cytokines and soluble mediators able to stimulate osteoclast differentiation and activation. Molecules that regulate osteoclastogenesis are key factors in many immunological functions. Osteoporosis and inflammageing share the same immunological profile. Osteoclastogenesis and inflammation are directly proportional to osteoclast precursor levels in peripheral blood. Characteristic of an agedi mmune profile is the accumulation of activated memory cells expressing RANKL, preferentially resident in the bone and secreting osteoclastogenic proinflammatory cytokines. The immunophenotypical analysis of peripheral blood lymphocyte subsets confirms the deep involvement of the immune system in bone remodelling. CD3+ T lymphocytes are increased in osteoporotic patients, as well as their CD4+/CD8+ ratio, whereas CD20+ B lymphocytes are significantly decreased. Moreover, the CD8+CD56+ lymphoid subset including killer/effector lymphocytes producing large amounts of the inflammatory cytokine TNF-α, is also expanded. In osteoporotic patients, as well as in elderly people, there is an increase in CD45RO+ memory lymphocytes, whereas the CD45RA+ naive subset is markedly decreased. Another important mechanism which could link inflammageing and osteoporosis is the dysregulation of T-regulatory cells producing soluble factors IL-10 and TGF-β, both able to antagonize immune mediated bone resorption. Visit www.sens.org/videos to view the rest of our SENS6 videos.
Просмотров: 1900 SENS Foundation
adipocyte.AVI
 
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human adipocyte expressing HA-GLUT4-GFP after insulin stimulation
Просмотров: 824 Coritze
Classical and Alternative NF-kappaB Pathways
 
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This animation reviews the classical and alternative NF-kappaB pathways that can be targeted for inhibition. It was presented at an independent satellite symposium "Expert Perspectives in Individualized Treatment of Hematologic Malignancies" at the 2010 ASCO meeting in Chicago, Illinois. Scenes Description. Scene 1: In the classical pathway, incoming stimuli to cell surface receptors initiate a cytoplasmic cascade, beginning with the activation of the IKK-gamma/IKK-alpha/IKK-beta complex. IKK-beta becomes phosphorylated. Scene 2: The IKK complex phosphorylates the IkappaB that is bound to the p50/p65 subunits of NF-kappaB and inhibits its activity. Scene3: Phosphorylated IkappaB undergoes ubiquitinylation followed by proteasomal degradation. This permits NF-kappaB translocation to the nucleus, leading to gene transcription of anti-apoptotic and inflammatory proteins. Scene 4: Bortezomib inhibits proteasomes, preventing the degradation of IkappaB, thereby indirectly inhibiting NF-kappaB transcription activity. Scene 5: In the alternative pathway, extracellular stimuli stimulate cell surface receptors, which leads to the activation of NIK. Scene 6: NIK phosphorylates dimerized IKK-alpha. Scene 7: The RelB/p100 complex is phosphorylated by the IKK-alpha dimer. Scene 8: Upon ubiquitinylation, p100 is cleaved. This yields a RelB/p52 complex which translocates to the nucleus to transcribe proteins related to lymphoid organ development and homeostasis.
Просмотров: 94348 Mechanisms in Medicine
Insulin Signaling (Signal Pathways)
 
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NDSU Virtual Cell Animations Project animation 'Insulin Signaling'. For more information please see http://vcell.ndsu.edu/animations. When high levels of glucose enter the blood stream, insulin is released by beta cells in the pancreas. Insulin then initiates a number of signal pathways in specific muscle and fat cells. This takes a look at the signal pathway responsible for allowing those cells to rapidly increase their ability to uptake glucose from the blood stream.
Просмотров: 263431 ndsuvirtualcell
Mutation
 
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In genetics, a mutation is a change of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal genetic element. Mutations result from unrepaired damage to DNA or to RNA genomes , errors in the process of replication, or from the insertion or deletion of segments of DNA by mobile genetic elements. Mutations may or may not produce discernible changes in the observable characteristics of an organism. Mutations play a part in both normal and abnormal biological processes including: evolution, cancer, and the development of the immune system. This video targeted to blind users. Attribution: Article text available under CC-BY-SA Public domain image source in video
Просмотров: 571 encyclopediacc
An Epigenomic and Transcriptional Basis for Insulin Resistance - Evan Rosen
 
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June 29 - July 1, 2015 -- ENCODE 2015: Research Applications and Users Meeting More: http://www.genome.gov/27561910
Просмотров: 617 National Human Genome Research Institute
Diabetes Researcher: Family Support - Dody Sears Career Girls Role Model
 
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Dorothy Sears, Ph.D., diabetes researcher at UCSD School of Medicine, shares valuable career guidance and life advice with girls. Watch her full interview at http://www.careergirls.org Welcome to our community! ♥ Website: http://www.careergirls.org ♥ Twitter: https://twitter.com/careergirlsorg ♥ Facebook: https://facebook.com/CareerGirls ♥ Instagram: http://instagram.com/career_girls ♥ Pinterest: http://www.pinterest.com/careergirlsorg/ ♥ CareerGirls Blog: http://www.careergirls.org/community
Просмотров: 25 careergirls
NINR Symptom Science Research Symposium
 
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On April 25, 2017, the NINR Intramural Research Program convened a scientific symposium, Symptom Science Research: A Path to Precision Health, on the NIH campus in Bethesda, Maryland, highlighting Intramural’s scientific advances and collaborations across the National Institutes of Health and other organizations.
Просмотров: 301 NINRnews
Francis Collins speaking at the Genbank 25th Anniversary
 
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Francis Collins Director, National Human Genome Research Institute (NHGRI), NIH, Bethesda, MD Genomics, Medicine and Society Slides available: http://www.ncbi.nlm.nih.gov/About/genbank25/data/day2/collins/index.html
Просмотров: 7101 NCBI
Chronic Hazard Advisory Panel: Phthalates AM Session
 
02:31:50
Original broadcast date: July 26, 2010
Просмотров: 84 U.S. Consumer Product Safety Commission
Chronic Hazard Advisory Panel: Phthalates Afternoon Session
 
03:24:42
Original broadcast date: July 27, 2010
Просмотров: 47 U.S. Consumer Product Safety Commission