На главную
Результаты поиска “Role of eicosanoid in cardiovascular disease”
NSAIDs and Heart Disease - Mayo Clinic
 
01:51
Have a headache? Chances are, when life causes aches and pains, many of us reach for the ibuprofen. But if you also take aspirin to protect against heart disease, there are some things you need to know.
Просмотров: 21831 Mayo Clinic
Eicosanoids -  AMBOSS ChalkTalk
 
11:48
AMBOSS - Medical Knowledge Distilled http://www.amboss.com Are you able to name the three subclasses of eicosanoids? Well, don't worry if you can't; we'll be addressing this question and much more in this ChalkTalk episode. An interactive version of this ChalkTalk episode can be found under: www.amboss.com/us/auditor/eicosanoids
Просмотров: 533 AMBOSS
Aspirin and Prostaglandins
 
08:36
Aspirin, or acetylsalicylic acid, is one of the oldest and most well-known medications for headaches, fever, pain, and even prevention of heart attack and stroke. How does this drug cause relief of these symptoms? Check out this episode of Medicurio to learn about the quite interesting mechanism of aspirin in the body. Detailed Mechanism of Aspirin: There are two major forms of cyclooxygenase (COX) in cells. COX-1 is always made in the cell, while COX-2 is only made during inflammation. Aspirin permanently inhibits the COX-1 isoform (version) by acetylation of its active site. Therefore, aspirin’s effect lasts however long it takes for the cell to transcribe and translate new COX-1 enzymes, which usually takes a few hours. COX-1 decreases fever, pain, and inflammation, but also increases the risk of gastric ulcers by decreasing clotting and stomach mucous production. The COX-2 isoform is thought to only produce prostaglandins involved in fever, pain, and inflammation but not other functions; therefore, making a drug that inhibits COX-2 instead of COX-1 would give all the anti-inflammatory effects of aspirin without the risk of gastric ulcers. Such a drug would be a major upgrade and many companies came up with possible COX-2 inhibitors. One such drug, called rofecoxib or Vioxx, entered the market claiming that it would not cause gastric ulcers. What the drug company did not reveal was that during clinical trials, many patients suffered from heart attacks after chronic use. These problems began to surface once the general public began using Vioxx, leading to withdrawal of the drug and lawsuits against the company. Moral of the story? Research integrity is important, especially for a drug company as people’s lives are at stake. Trivia about Aspirin: It is debated if Felix Hoffmann was the true “inventor” of aspirin. Arthur Eichengrün, a fellow Bayer employee, claimed that he was the one who came up with the procedure and that Hoffmann simply performed the reaction following his guidelines. Bayer has denied this claim. Hoffmann synthesized aspirin for his father, who complained about the taste of salicylic acid that he was taking to treat his arthritis. Aspirin is extremely toxic to cats (which cannot break down aspirin) and to a lesser extent, dogs. Despite this, aspirin can still be used, just at low doses, to treat inflammation in animals. You can overdose on aspirin – at lethal doses, aspirin interferes with energy production in the mitochondria which leads to eventual death. Before death, unique symptoms such as ringing in the ears, hyperventilation, and dizziness, as well as non-specific symptoms such as vomiting and nausea appear. Overdoses are often due to chronic aspirin use, so if any of these symptoms apply to you, speak to a doctor immediately. Aspirin’s effect is increased by ingesting it with caffeine because caffeine is a stimulant, which increases blood flow to carry aspirin around the body faster and begin acting on tissue quicker. Acetaminophen (Tylenol) is not technically an NSAID because it does not decrease inflammation; however, it also works on COX enzymes so I have lumped it with the other NSAIDs in this video for simplicity.
Просмотров: 94114 Medicurio
Endothelial Secretions for Cardiovascular Regulation - Prostaglandins - Nitric Oxide - Endothelins
 
07:26
Check out the following links below! Over 1000+ Medical Questions: http://www.5minuteschool.com DONATE + SUPPORT US: http://paypal.me/5minuteschool Patreon: https://goo.gl/w841fz Follow us on Twitter: http://twitter.com/5MinuteSchool Follow us on Instagram: http://instagram.com/5minuteschool My personal Instagram: http://instagram.com/shahzaebb Contact us: contact@5minuteschool.com ______ ◅ Donate: http://www.5minuteschool.com/donate ◅ Website: htttp://www.5minuteschool.com ◅ Twitter: http://www.twitter.com/5minuteschool ◅ Instagram: http://www.instagram.com/5minuteschool ◅ Facebook: http://www.facebook.com/5minuteschool ◅ Email: contact@5minuteschool.com
Просмотров: 6863 5MinuteSchool
Inflammation 2, Causes of Imflammation
 
07:08
If you would like to get hold of my books, one on Physiology and another on Pathophysiology, check out my web site campbellteaching.co.uk Funds from selling books helps to finance distribution of resources to students in poorer countries.
Просмотров: 20698 Dr. John Campbell
Inflammatory response | Human anatomy and physiology | Health & Medicine | Khan Academy
 
14:35
Overview of the inflammatory response. Created by Sal Khan. Watch the next lesson: https://www.khanacademy.org/science/health-and-medicine/human-anatomy-and-physiology/introduction-to-immunology/v/rn-blood-cell-lineages?utm_source=YT&utm_medium=Desc&utm_campaign=healthandmedicine Missed the previous lesson? https://www.khanacademy.org/science/health-and-medicine/human-anatomy-and-physiology/introduction-to-immunology/v/how-white-blood-cells-move-around?utm_source=YT&utm_medium=Desc&utm_campaign=healthandmedicine Health & Medicine on Khan Academy: No organ quite symbolizes love like the heart. One reason may be that your heart helps you live, by moving ~5 liters (1.3 gallons) of blood through almost 100,000 kilometers (62,000 miles) of blood vessels every single minute! It has to do this all day, everyday, without ever taking a vacation! Now that is true love. Learn about how the heart works, how blood flows through the heart, where the blood goes after it leaves the heart, and what your heart is doing when it makes the sound “Lub Dub.” About Khan Academy: Khan Academy is a nonprofit with a mission to provide a free, world-class education for anyone, anywhere. We believe learners of all ages should have unlimited access to free educational content they can master at their own pace. We use intelligent software, deep data analytics and intuitive user interfaces to help students and teachers around the world. Our resources cover preschool through early college education, including math, biology, chemistry, physics, economics, finance, history, grammar and more. We offer free personalized SAT test prep in partnership with the test developer, the College Board. Khan Academy has been translated into dozens of languages, and 100 million people use our platform worldwide every year. For more information, visit www.khanacademy.org, join us on Facebook or follow us on Twitter at @khanacademy. And remember, you can learn anything. For free. For everyone. Forever. #YouCanLearnAnything Subscribe to Khan Academy’s Health & Medicine channel: https://www.youtube.com/channel/UC1RAowgA3q8Gl7exSWJuDEw?sub_confirmation=1 Subscribe to Khan Academy: https://www.youtube.com/subscription_center?add_user=khanacademy
Просмотров: 1235927 Khan Academy
The Role of Molecular Clocks in Cardiovascular Disease
 
05:36
Josh Beckman, MD, chair of the council on Peripheral Vascular Disease, interviews Distinguished Lecturer Garret FitzGerald, MD about his research on the role of molecular clocks in cardiometabolic disease.
Просмотров: 257 AHAScienceNews
ECG 3 - Segments, Intervals & Diseases
 
05:10
http://www.handwrittentutorials.com - This tutorial is the third in the ECG series. This video explores the various segments and intervals seen on an ECG trace and how changes in these divisions can be indicative of various heart diseases. For more entirely FREE tutorials and their accompanying PDFs, visit http://www.handwrittentutorials.com
Просмотров: 118169 Handwritten Tutorials
TheSynapse eLearning - Role of Aspirin in Prevention of Cardiovascular Disease
 
11:22
Aspirin was discovered in 1897. Since then it has been used extensively in the prevention of Cardiovascular disease. The ESC Guidelines 2012 state that 'Aspirin cannot be recommended in primary prevention due to its increased risk of major bleeding' This video highlights the role of aspirin in current practice.
Просмотров: 401 TheSynapse
The Endocannabinoid System [ECS] and its Role in Metabolic Processes
 
07:41
The Endocannabinoid System: An Overview 'Marijuana has been used as a medicine for thousands of years with evidence dating back to 2000 BC, but only in the past few decades have scientists truly understood how it works. What led to this understanding was the discovery of the endocannabinoid system; a unique biological system that facilitates the effects of marijuana within the human body. The endocannabinoid system is a central regulatory system that affects a wide range of biological processes. It consists of a group of molecules known as cannabinoids as well as the cannabinoid receptors that they bind to. Although marijuana is a source of over 60 cannabinoids (including THC and CBD), the human body produces a number of cannabinoids as well. These endogenous cannabinoids include anandamide and 2-arachidonoylglycerol (2-AG) and are present in all human beings. Decades of scientific research on the endocannabinoid system has resulted in the discovery of two types of cannabinoid receptors, CB1 and CB2. These receptors are found in various parts of the body, but are most prominent in the brain and immune system. Cannabinoid receptors act as binding sites for endogenous cannabinoids as well as cannabinoids found in marijuana. When cannabinoids bind to CB1 or CB2 receptors, they act to change the way the body functions. While cannabinoid receptors are primarily expressed in the brain and immune system, researchers have identified cannabinoid receptors in a variety of other places as well, including the peripheral nervous system, cardiovascular system, reproductive system, and gastrointestinal and urinary tracts. Cannabinoid receptors continue to be identified in unique parts of the body as research on the endocannabinoid system progresses.' Full article ~ http://www.truthonpot.com/2013/03/22/the-endocannabinoid-system-an-overview/ Wiki - Endocannabinoid System 'The endocannabinoid system is a group of neuromodulatory lipids and their receptors in the brain that are involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory; it mediates the psychoactive effects of cannabis and, broadly speaking, includes: The endogenous arachidonate-based lipids, anandamide (N-arachidonoylethanolamide, AEA) and 2-arachidonoylglycerol (2-AG); these are known as "endocannabinoids" and are physiological ligands for the cannabinoid receptors. Endocannabinoids are all eicosanoids. The enzymes that synthesize and degrade the endocannabinoids, such as fatty acid amide hydrolase or monoacylglycerol lipase. The cannabinoid receptors CB1 and CB2, two G protein-coupled receptors that are located in the central and peripheral nervous systems. The endocannabinoid system has been studied using genetic and pharmacological methods. These studies have revealed that cannabinoids act as neuromodulators for a variety of physiological processes, including motor learning, synaptic plasticity, appetite, and pain sensation.' Full article ~http://en.wikipedia.org/wiki/Endocannabinoid_system National Center for Biotechnology Information (NCBI) - The Endocannabinoid System as an Emerging Target of Pharmacotherapy 'The recent identification of cannabinoid receptors and their endogenous lipid ligands has triggered an exponential growth of studies exploring the endocannabinoid system and its regulatory functions in health and disease. Such studies have been greatly facilitated by the introduction of selective cannabinoid receptor antagonists and inhibitors of endocannabinoid metabolism and transport, as well as mice deficient in cannabinoid receptors or the endocannabinoid-degrading enzyme fatty acid amidohydrolase. In the past decade, the endocannabinoid system has been implicated in a growing number of physiological functions, both in the central and peripheral nervous systems and in peripheral organs. More importantly, modulating the activity of the endocannabinoid system turned out to hold therapeutic promise in a wide range of disparate diseases and pathological conditions, ranging from mood and anxiety disorders, movement disorders such as Parkinson’s and Huntington’s disease, neuropathic pain, multiple sclerosis and spinal cord injury, to cancer, atherosclerosis, myocardial infarction, stroke, hypertension, glaucoma, obesity/metabolic syndrome, and osteoporosis, to name just a few.' Full overview ~ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241751/ Copyright Disclaimer - allowance is made for "Fair Use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use. No copyright infringement intended. All rights and credit go directly to its rightful owners.
Просмотров: 63081 Decriminalise it - Jersey
HEART DISEASE: GENETIC VARIATIONS IN CHOLESTEROL TRANSPORT
 
01:36
HEART DISEASE_GENETIC VARIATIONS IN CHOLESTEROL TRANSPORT
Просмотров: 1351 Walter Jahn
Polymorphisms in genes involved in vasoactive eicosanoid synthesis affect cardiovascular risk
 
03:06
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com, https://plus.google.com/communities/115462130054650919641?sqinv=VFJWaER0c2NCRl9ERzRjZWhxQmhzY09kVV84cjRn , ,https://plus.google.com/u/0/+AlexandrosGSfakianakis , https://www.youtube.com/channel/UCQH21WX8Qn5YSTKrlJ3OrmQ , https://www.youtube.com/channel/UCTREJHxB6yt4Gaqs4-mLzDA , https://twitter.com/g_orl?lang=el, https://www.instagram.com/alexandrossfakianakis/, Polymorphisms in genes involved in vasoactive eicosanoid synthesis affect cardiovascular risk in renal transplant recipients Guillermo Gervasini, Enrique Luna, Guadalupe Garcia-Pino, Lilia Azevedo, Sonia Mota-Zamorano & Juan José Cubero https://doi.org/10.1080/03007995.2017.1391757 Abstract Objective: Arachidonic acid metabolism by cytochrome P450 (CYP) epoxygenases leads to epoxyeicosatrienoic acids (EETs), which are eicosanoids with vasodilator and anti-inflammatory properties. We aim to determine whether genetic variability in these routes may contribute to cardiovascular (CV) risk in renal transplant recipients. Methods: In a cohort of 355 patients, we determined the presence of two polymorphisms, CYP2C8*3 and CYP2J2*7, known to affect eicosanoid levels. Associations with CV mortality, CV event-free long-term survival and graft survival were retrospectively investigated by logistic regression models. Results: CYP2J2*7 showed a statistical trend towards higher CV mortality (p = .06) and lower cardiac or cerebral event-free long-term survival (p = .05), whilst CYP2C8*3 displayed a significant inverse association with the risk of CV event (hazard ratio [HR] = 0.34 [0.15–0.78], p = .01). The association of CYP2J2*7 with CV mortality became significant when the analysis was restrained to 316 patients without a history of CV events prior to transplantation (HR = 15.72 [2.83–91.94], p = .005). In this subgroup of patients both single nucleotide polymorphisms (SNPs) were significantly associated with event-free survival. HR values were 5.44 (1.60–18.51), p = .007 and 0.26 (0.09–0.75), p = .012 for CYP2J2*7 and CYP2C8*3, respectively. Conclusions: Our results show, for the first time to our knowledge, that two SNPs in CYP2C8 and CYP2J2, which synthesize EETs, may modify CV outcomes in renal transplant recipients, a population that is already at a high risk of suffering these events. Keywords: Epoxyeicosatrienoic acids, cardiovascular disease, genetic polymorphisms, renal transplant, CYP450 - video upload powered by https://www.TunesToTube.com
Просмотров: 10 Alexandros G. Sfakianakis
Inflammation in 100 Seconds
 
02:01
While routine lipid screening plays an important role in cardiovascular risk assessment it does not provide a complete picture of your health. In fact, nearly 50% of all heart attacks and strokes occur in patients with ‘normal’ cholesterol levels. Recent evidence goes beyond lipids to suggest that inflammation within the artery wall is the primary contributor to this residual risk for heart attack and stroke. Inflammation contributes to both vulnerable plaque formation and to plaque rupture.
Просмотров: 480 Cleveland HeartLab
NSAID Pharmacology: What is a Prostaglandin?
 
09:55
This video examines a fascinating class of endogenous hormones called prostaglandins. It is a general introduction to the characteristics of these signalling molecules as well as some of their chemical properties. The lecture ends by placing prostaglandins in the context of the NSAID mechanism of action. Enjoy! #khanacademytalentsearch
Просмотров: 67868 Armaan Malhotra
Heart Disease and Inflammation
 
03:50
Get to the HEART of the matter.... It's NOT Fat!!! (Healthy fat doesn't cause inflammation.)
Просмотров: 86 mWell Solutions
Dietary Fats: Healthy Fat vs. Bad Fat- Thomas DeLauer
 
08:55
http://ThomasDeLauer.com Click here to subscribe to my YouTube Channel : https://www.youtube.com/thetdelauer?sub_confirmation=1 Monounsaturated Fats: Oleic Acid - Omega 9- These Protect Cell Membranes from Free Radicals. Oleic acid replaces other omega fatty acids in cell membranes. Since oleic acid is less susceptible to oxidation damage than omega-6 and omega-3 fatty acids, replacing these fatty acids with oleic acid protects your cell membranes from free radicals and other oxidative stressors (1) Palmitoleic Acid - Omega 7- These Reduce Insulin Resistance. Omega-7 protects the insulin-producing cells of the pancreas from glucose-induced toxicity - enhances proliferation of pancreatic beta cells, helping your body optimize blood sugar control with its own natural insulin (2) Reduce Inflammation- Study from the Cleveland Clinic Wellness Institute in Ohio conducted the first randomized, controlled trial in humans of supplementation with purified omega-7. Subjects were randomly assigned to receive either an omega-7 supplement providing 220 mg palmitoleic acid or a placebo - capsules were taken once daily, with a meal, and blood testing was done at the beginning of the study and again after 30 days. At 30 days, the supplemented group showed a significant mean lowering in C-reactive protein with a 44% reduction compared with the control group. Omega-7-supplemented subjects also had 15% reductions in triglyceride levels (3) Polyunsaturated Fats: Omega 3 & 6- Omega 3’s- Eicosapentaenoic acid (EPA): This 20-carbon fatty acid's main function is to produce chemicals called eicosanoids, which help reduce inflammation. EPA also helps reduce symptoms of depression. Docosahexaenoic acid (DHA): A 22-carbon fatty acid, DHA makes up about 8% of brain weight and is extremely important for normal brain development and function. EPA and DHA support cellular membranes and keep them flexible - maintaining the fluidity of the cell membranes allows for proper communication between nerve cells and, therefore, helps to support focus and mental clarity. Alpha-linolenic acid (ALA): This 18-carbon fatty acid can be converted into EPA and DHA, although the process is not very efficient. ALA is mainly used by the body for energy (4) Omega 6’s: The most common omega-6 fat is linoleic acid, which can be converted into longer omega-6 fats such as arachidonic acid (ARA) Like EPA, ARA is used to produce eicosanoids - however, the eicosanoids produced by ARA are more pro-inflammatory. Pro-inflammatory eicosanoids are important chemicals in the immune system, but when too many of them are produced, they can increase inflammation - modern Western diet contains far more omega-6 fatty acids than necessary (4) Trans Fats: Trans fats block the production of Type 1 and 3 prostaglandins (PGs), which are derived from the omega 6 and omega 3 fats, respectfully. Type 1 and 3 PGs help you fight inflammation and benefit your hormonal and nervous system (5) Saturated Fats: Studies in favor of saturated fats- A meta-analysis study, published 2010, which pooled data from 21 studies and included nearly 348,000 adults, found no difference in the risks of heart disease and stroke between people with the lowest and highest intakes of saturated fat (6) A Japanese prospective study that followed 58,000 men for an average of 14 years found no association between saturated fat intake and heart disease, and an inverse association between saturated fat and stroke (i.e. those who ate more saturated fat had a lower risk of stroke) (7) References: 1) Oleic Acid Health Benefits: MooScience. (n.d.). Retrieved from http://mooscience.com/Oleic-Acid.html 2) Omega-7 Protects and Metabolic Syndrome - page 1 | Life Extension. (n.d.). Retrieved from http://www.lifeextension.com/Magazine/2014/4/Omega-7-Protects-Against-Metabolic-Syndrome/Page-01 3) Omega-7 An Overlooked Fatty Acid - Life Extension. (n.d.). Retrieved from http://www.lifeextension.com/Magazine/2016/5/Omega-7-An-Overlooked-Fatty-Acid/Page-01 4) Omega-3-6-9 Fatty Acids: A Complete Overview. (2017, January 15). Retrieved from https://www.healthline.com/nutrition/omega-3-6-9-overview#section4 5) Hydrogenated Fat Dangers | Understand Trans Fats Dangers. (n.d.). Retrieved from http://www.drgangemi.com/health-topics/nutrition-and-supplements/hydrogenated-fat-dangers/ 6) Dietary intake of saturated fatty acids and mortality from cardiovascular disease in Japanese: the Japan Collaborative Cohort Study for Evaluation ... - PubMed - NCBI. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/20685950?dopt=AbstractPlus 7) PubMed. (n.d.). Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/20071648?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2%20Am%20J%20Clin%20Nutr
Просмотров: 182467 Thomas DeLauer
Lipoprotein-Associated Phospholipase A2 Activity, Serum
 
06:37
The new Lipoprotein-Associated Phospholipase A2 Activity, Serum, test is now available to the Mayo Clinic practice and Mayo Medical Laboratories clients. This test should be used as an adjunct to traditional cardiovascular risk factors for identifying individuals at higher risk of coronary heart disease events. Leslie Donato, Ph.D., gives a video overview of the test:
Просмотров: 1339 Mayo Clinic Laboratories
Autacoids - 03 - Prostaglandins, TXA2, leukotrienes
 
58:06
Video lectures in clinical pharmacology by Dr. Abdel-Motaal Fouda, associate professor of clinical pharmacology, Mansoura Faculty of Medicine. 2016. foudaamm@mans.edu.eg
Просмотров: 18402 Abdel-Motaal Fouda
Hypertension Regulation
 
27:24
Prof. Michal Laniado Schwartzman presents how cytochrome P450-derived eicosanoids play a role in the regulation of hypertension, based on a new research project that she is carrying out. The lecture was one of the faculty lectures at the Rambam Health Care Campus. View this and other programs on the Academic Channel- www.actv.haifa.ac.il/programs
EPA and Cox 1 Enzyme
 
02:45
EPA and Cox 1 Enzyme Dr. Barry Sears is a leading authority on the impact of the diet on hormonal response, genetic expression, and inflammation. A former research scientist at the Boston University School of Medicine and the Massachusetts Institute of Technology, Dr. Sears has dedicated his research efforts over the past 30 years to the study of lipids. He has published more than 30 scientific articles and holds 13 U.S. patents in the areas of intravenous drug delivery systems and hormonal regulation for the treatment of cardiovascular disease. He has also written 13 books, including the New York Times #1 best-seller "The Zone". These books have sold more than 5 million copies in the U.S. and have been translated into 22 different languages. For more, go to zonediet.com
Просмотров: 969 Dr. Barry Sears
Anatomy of the Heart
 
04:20
http://www.handwrittentutorials.com - This tutorial explores the gross anatomy of the heart. It covers the chambers, vessels and valves of the heart. For more entirely FREE medical tutorials, visit http://www.handwriitentutorials.com
Просмотров: 95808 Handwritten Tutorials
Microbiome – Your Microbiome and Relief From Chronic Inflammation
 
06:19
http://www.oursynergyfamily.com/microbiomejudy/ To contact Judy Feldhausen for a free 30 minute consultation, please click on the above link. http://www.oursynergyfamily.com/microbiomedan/ To contact Dan Hammer for a free 30 minute consultation, please click on the above link. Almost every lifestyle disease today is affected by chronic inflammation. Some researchers would say that if you can eliminate chronic inflammation, then you can significantly reduce all diseases. If this is true, then the question is: How Do You Get Relief From Chronic Inflammation? And more importantly: How Do You Prevent Chronic Inflammation? And the answer to both of these questions is centered in what is called the (icosanoid) eicosanoid pathway. Just as there is an endothelial pathway for the creation of nitric oxide for improved cardiovascular health. There is also an eicosanoid pathway that significantly influences inflammation in your body. The easiest way to understand the eicosaniod pathway is to view it as a light switch. If you want the lights on in your room (inflammation), then you flip the switch to “ON.” If you want the lights off, then you flip the switch to “OFF.” The eicosaniod pathway works the same way. This pathway helps turn on inflammation when it's needed. And once your body has used inflammation to help in the healing process, then it turn off this process. As in nitric oxide therapy were nitric oxide is the signaling molecule used to create vasodilation for improved blood flow, the eicosaniod pathway uses two signaling molecules. One that is pro-inflammatory. And one that is anti-inflammatory. Pro-inflammatory signaling molecules are produced from omega-6 fatty acids. And anti-inflammatory signaling molecules are mainly produced from omega-3 fatty acids. As outlined in our video titled how your microbiome impacts weight loss, you will remember that steps 1 and 2 directly center on this issue of omega-6 and omega-3 fatty acids. As I shared in that video: https://www.youtube.com/watch?v=NTtsjq3ks7s&t=25s Step #1 – Eliminate omega-6 vegetable oils from your diet. Ones like Corn Oil Soybean Oil Canola Oil Vegetable Oil Peanut Oil While the food industry, and our government, have tried to convince us that these omega-6 vegetable oils are safe and heart-healthy, they are not. These oils are inflammatory, and help create an environment that allow Firmicutes to flourish, which then creates toxins that your body has to address. The easiest way for your body to remove these toxins from your system is to store them in fat cells. And the more toxins your gut microbiome produces, the more fat cells your body needs to store them. The result is weight gain through larger and more fat cells. Not only do the omega-6 vegetable oils affect your microbiome and weight management, they are also the main trigger that turns on inflammation. When used properly inflammation can be a good thing as it's involved in the wound healing process. But when the “light switch” is left on, then it becomes chronic inflammation, which contributes to almost all disease processes. Now you need to do more than just eliminate these omega-6 vegetable oils from your diet. You need to do: Step #2 – Replace the omega-6 vegetable oils with omega 3 healthy fats like Coconut Oil Avocados Grass-fed Butter Fish Rich in Omega 3s Grass-fed Beef Extra-virgin Olive Oil When used in weight management studies, these healthy, anti-inflammatory omega 3 fats create an environment where healthy gut flora can dominate, which lowers inflammation levels, produces significantly less toxins, and increases the probability of weight loss. And as we've seen, they also act as signaling molecules to turn off inflammation. Omega-3 fats also play a significant role in the prevention of: Cardiovascular Disease Neurodegenrative Disorders like Alzheimer's Disease Type II Diabetes Osteoporosis Atherosclerosis Atrial Fibrillation Osteoarthritis The bottom line to all of this information is that the key to the “relief of” and “prevention of” chronic inflammation is eliminating omega-6 fats from your diet. And replacing them with omega-3 fats. This one change can have a profound health benefit for every organ and organ system in your body. As well as helping to improve your endothelial health and function for improved blood flow. And by implementing these two steps into your diet you will also significantly influence your microbiome in a positive way. If you have any questions about this material, then please either email me at dan@agingnomore.com or call me directly at 630-936-8079. Or you can email Judy at Judy@CardioWellnessGroup.com or call her directly at 630-289-2750.
Просмотров: 113 Daniel Hammer
Prudence Sinclair interviews Dr. Barry Sears -  What would you do if you got cancer?
 
06:01
Find out what Dr. Barry Sears would do if God forbid he was diagnosed with Cancer. Subscribe to my channel to get more interviews. wwwprudenncesinclair.com Dr. Barry Sears: Dr. Barry Sears is a leading authority on the dietary control of hormonal response. A former research scientist at the Boston University School of Medicine and the Massachusetts Institute of Technology, Dr. Sears has dedicated his research efforts over the past 30 years to the study of lipids. He holds 13 U.S. Patents in the areas of intravenous drug delivery systems and hormonal regulation for the treatment of cardiovascular disease. A turning point in his research occurred in 1982. That year the Nobel Prize in Medicine was awarded for discoveries of the role that specialized hormones known as eicosanoids play in the development of cardiovascular disease, diabetes, auto-immune diseases, and cancer. Since eicosanoids are only generated from dietary fat, Dr. Sears reasoned that one could apply intravenous drug-delivery principles to nutrition in order to control these exceptionally powerful hormonal responses with laser-like precision. In essence, his approach treats food as if it were a drug. This area of his research led to various patents in the area of hormonal control by essentially using food as an oral drug-delivery system to modulate eicosanoids, especially for cardiovascular, diabetic, and neurological patients.
Histamine, Prostaglandin, Leukotrienes, Bradkinin, PGE2 LTB4 Chemotactic Factors
 
14:05
http://www.stomponstep1.com/histamine-prostaglandin-leukotrienes-bradkinin-pge2-ltb4-chemotactic-factors/ There are a groups of inflammatory signals that play key roles in the early phases of acute inflammation. These signals cause the cardinal signs of inflamation and are involved in the inflammatory mechanism. The Cardinal Signs of Inflammation are the signs and symptoms that results directly from acute inflammation. * Fever is associated with inflamation and is caused by the release of PGE2 (Prostaglandin E2), however it is not a cardinal sign of inflammation. Histamine is released from mast cells in response to cell injury, complement activation, or membrane bound IgE being crosslinked by antigen. Histamine then increases venule permeability, dilates the arterioles and prepares the vessel wall for neutrophil extravasion. In other words, Histamine is the main signal that initiates the fluid phase (But it gets helps from other cytokines). Histamine is the mediator of type 1 hypersensitive reactions (anaphylaxis & allergies) and signals stomach acid to be secretion. Antihistamines that primarily antagonize the H1 Histamine receptors are used to treat allergic symptoms, while antihistamines that primarily antagonize the H2 Histamine receptor are used to treat things like GERD and Peptic Ulcer Disease. Histamine has the help of other signals during acute inflammation. Following injury, Coagulation Factor XII (Hageman Factor) is activated by exposed collagen in the vessel wall. Factor XII then initiates the Kinin-Kallikrein System that creates Bradykinin. Bradykinin plays an important role in pain, arteriole dilation and increased venule permability during acute inflammation. We will cover elsewhere the effect coagulation factor 12 has on clotting. Angiotensin Converting Enzyme (ACE) breaks down bradykinin. Therefore, ACE Inhibitors increase bradykinin levels which can cause cough, angioedema and vasodilation. Arachidonic Acid is created when cell membrane phospholipids are acted upon by Phospholipase A2. Arachidonic Acid which is acted upon by Cycloxygenase to create Prostaglandins or Lipoxygenase to create Leukotrienes. Both classes of signal molecule play a role in acute inflammation by contributing to the fluid phase (arteriole dilation and venule permeability). PGE2 (Prostaglandin A2) is involved in the signaling process for pain and fever. LTB4, a specific type of leukotriene, is also a Chemotactic Factors which means it attracts neurtophils to the site of injury (AKA leukocytosis). The other main Chemotactic Factors are IL-8 and C5a. We will discuss prostaglandins and leukotrienes in many other videos as they are involved with the pathophysiology and treatment of many disease. Leukotrienes are involved in the pathophysiology of Asthma and their action is antagonized by receptor blocker Montelukast. Both class of molecule can be reduced to lessen the pain and inflammation. Corticosteroids inhibit Phospholipase A2 to decrease the levels of prostaglandins and Leukotrienes. NSAIDs inhibit Cyclooxygenase to decrease prostaglandin levels. Synthetic prostaglandins can be used to keep a Patent Ductus Arteriosus open in a newborn (if they have a congential heart defect that requires that route of blood flow), while an NSAID like Indomethacin can be used to close a PDA. Nuetrophils are the predominant inflammatory cell in acute inflammation. They phagocytose (engulf) infected or necrotic cells and use free radicals to destroy them. They also release granules full of proteins and enzymes that help fight infection or clear cellular debris. Neutrophils are attracted to and activated by chemotactic factors (Leukotriene B4, C5a, and Interleukin-8) created during acute inflammation. Neutrophil extravasation (AKA Leukocyte extravasation) is the process by which neutrophils exit the circulatory system into the damaged tissue. Later in the inflammatory process Macrophages use these same steps to get to the effected tissue. Pictures Used: • Derivative of “Leukozytenmigration 01” by Armin Kübelbeck available at http://commons.wikimedia.org/wiki/File:Leukozytenmigration_01.png via Creative Commons Attribution • “Lips Mouth Smile Teeth Happy Laugh Red White” available at http://pixabay.com/en/lips-mouth-smile-teeth-happy-156991/ via Public Domain
Просмотров: 40380 Stomp On Step 1
Polyphenols (antioxidant and anti inflammatory) MGM8
 
12:14
A basic explanation of polyphenols and their benefits as well as where you find them. Polyphenols are a fighting force against heart disease, cancer, aging, Alzheimer's, diabetes and obesity.
Просмотров: 65 Muscle Growth Mindset
3 Essential Fats You Need For Intermittent Fasting (AVOID The #1 Poisonous Fat)
 
09:01
Train With The Most Effective Methods For Six Pack Abs: http://go.sixpackabs.com/scienf9ed Check Out Thomas' Channel: http://www.YouTube.com/TheTDeLauer What's going on, SixPackAbs.com? Thomas here to talk about fat - or rather, fats - both good and bad ones. I want you to take this knowledge about fats moving forward and incorporate into the fasting lifestyle I've broken down for you in all my videos. Let's dive right in: 2:21 - Monounsaturated Fats -Monounsaturated fats are fat molecules that have one unsaturated carbon bond in the molecule, also known as a double bond. -Oils that contain monounsaturated fats are typically liquid at room temperature but start to turn solid when chilled. -Oleic Acid - Omega 9 - helps to reduce blood pressure, but occupies a particular part of a cell, making it become extra protected. -Palmitoleic Acid - Omega 7 - helps the body utilize fats more efficiently and dramatically reducing insulin resistance. -Omega-7 protects the insulin-producing cells of the pancreas from glucose-induced toxicity. -Omega-7 & Inflammation: http://www.ncbi.nlm.nih.gov/pubmed/25499944 4:35 - Polyunsaturated Fats - Omega 3 & 6 -Eicosapentaenoic Acid (EPA) in Omega 3 is a 20-carob fatty acid and its main function is to produce chemicals called eicosanoids, which help reduce inflammation. -Docosahexaenoic Acid (DHA) in Omega 3 is a 22-carbon fatty acid that makes up about 8% of brain weight and is extremely important for normal brain development and function. -Alpha-linolenic Acid (ALA) in Omega 3 is an 18-carbon fatty acid that can be converted into EPA and DHA, although the process is not very efficient. -Omega 6 is found in the so-called "healthy fats" like vegetable oil, safflower oil, canola oil, etc. -Like EPA, Omega 6 is used to produce eicosanoids - however, the eicosanoids it produces are more pro-inflammatory. 6:54 - Trans Fats -Mechanically-altered fats. -It takes 51 days to begin breaking down trans fats... -Trans fats block the production of Type 1 and 3 prostaglandins, which are derived from the omega-6 and omega-3 fats. -Stay away from Cool Whip and things that have "partially-hydrogenated soybean oil." 7:48 - Saturated Fats -Coconut oil, palm oil, and fats that come from animals that are sustained and ethically raised. -These are NOT bad. -There is zero correlation between stroke and cardiovascular risk for those that consume high levels of saturated fats as opposed to those who consume a high level of regular fats: http://ajcn.nutrition.org/content/91/3/535 The point of today's video is MODERATION. Saturated fats are good for your immune system, tremendously powerful for your brain health, and yield a plethora of other health benefits the mainstream media has led you to think otherwise about. Thanks for tuning in with me, guys. Don't forget - "LIKE" "SHARE" & "SUBSCRIBE" to SixPackAbs.com. Train Smart, -Thomas Achieve Six Pack Abs The Fastest Way Possible - Using Science: http://go.sixpackabs.com/scienf9ed P.S. Make sure to "Like" & "Share" this video on Facebook: http://sixpackabs.com/3-essential-fats-you-need-for-intermittent-fasting-avoid-the-1-poisonous-fat/
Просмотров: 178066 SixPackAbs.com
NSAIDs and Renal Function
 
01:02
See how non-steroidal anti-inflammatory drugs (NSAIDs) can affect kidneys with some degree of dysfunction and potentially further compromise renal function. For more information on the safety differences of OTC analgesics, visit http://www.tylenolprofessional.com/the-tylenol-difference.html This video is intended for U.S. healthcare professionals only. ©McNEIL-PPC, Inc. 2013. All rights reserved.
Просмотров: 19810 TYLENOLOFFICIAL
Can cortisol cause inflammation ? | Best Health Channel
 
00:42
Until now, it has not been clear exactly how stress influences disease and health. Googleusercontent search. Avoid these 10 foods that increase cortisol & impede optimal top 5 causes of chronic inflammation youtube. Cortisol its role in stress, inflammation, and indications for diet cortisol todaysdietitian newarchives 111609p38. A silent killer in our midst the christian broadcasting network. Systemic inflammation, as noted previously, causes elevated cortisol levels. Each of these three hormones contributes to silent inflammation. From stress to inflammation and major depressive disorder a the anti inflammatory effects of cortisol wilson's wikipedia. 9 2008 a study now reveals that stress causes deterioration in everything from your prolonged exposure to cortisol inhibits the growth of new neurons, and can cause ordinarily, inflammation is how the healthy body deals with 16 low cortisol levels can greatly affect the quality of your life, causing such as inflammatory disorders, certain types of cancers, psoriasis, and 17 some types of inflammation can cause so much stress on our body cortisol decreases the inflammatory pathways within the body's tissue as you can see, inflammation is quite common and caused by more than just emotional or physical stress raises the level of cortisol, creating inflammation these disorders are caused by the inflammation and cortisol we produce to fight most people with untreated cushing's syndrome will die from heart disease 7 most of us can probably guess that stress affects the body negatively cortisol plays a significant role in turning off inflammatory reactions 17 by planning your diet wisely, you can help lower cortisol causing inflammation, activating the immune system, and altering stress hormone 23. Eicosanoids how can the type of fat you eat cause silent inflammation? As a lipid 29 2011 stress hormone cortisol elevates during stress, and in short term this internally caused inflammation take toll on skin however, chronically high levels blood decrease white cells glucocorticoids, since they reduce inflammatory response this, causes atrophy muscle (mainly fast twitch 2) bone learn fibromyalgia trigger pain to overcome it so does come into picture? . Inflammation skin enemy number one youbeauty precision nutrition. This can trigger the hyperkalemia of metabolic shock from surgery while both physical and emotional stress inflammation, turning off process is controlled by cortisol, our body's anti hormone 20 in this way, chronic inflammation lurk like a silent enemy with these hormones then cause body to produce more cortisol (the 24 do you know what does why need it, though? The decreased blood flow gi tract also incredible problems decreases reducing secretion 23 medication use, poor sleep diet high levels altering hormonal balances negatively 6 2007 order understand just how affect immune system, standpoint, delayed inflammatory response caused cortisol's however, elevated prolonged or side lower your immunity 11 causes cortisolwhat increases inflammatory, but it arthritis addition, either intestinal chemicals imbalances due fatigue findings about role play? In patients undergoing cardiac surgery, procedure that lot steroid regulates wide range processes acting as an influencing memory formation, controlling salt water over time lack sex drive and. Cortisol helps to mobilize blood sugar so that you can run effectively and efficiently. Revealing the fundamentals of chronic inflammation and adrenal ups downs cortisol what you need to know. Inflammatory findings about cortisol dartmouth medicine magazineyou and your hormones from the society for endocrinology. Does stress cause digestive problems? Kelsey kinney. Inflammation the real cause of all disease and how to reduce cortisol potbelly syndrome. From gut to brain the inflammation connection kelly. Shtml url? Q webcache. If we can naturally decrease inflammation in the body and minimize stress, decreased cortisol levels should follow, resulting chronic disease risk improved wellness 2 summary stress wreaks havoc on mind. Cortisol top 10 negative health effects and surprising benefits the stress effect richard weinstein, dc benjamin designs. Breaking cortisol levels under control naturally drstress, cortisol, and the immune system what makes us get sick? The stress connection. Cortisol and fibromyalgia triggers pain & inflammation learn how stress causes whole body deterioration news medical. When used as a examples include inflammatory and rheumatoid diseases, well allergies. Cohen argued that prolonged stress alters the effectiveness of cortisol to regulate inflammatory response because it decreases tissue sensitivity hormone adrenal fatigue can play havoc with your levels, sending them either too this causes inflammation, which is often a good thing (it means immune 13 increases in inflammation turn elicit profound changes altered or prolonged, actually cause conceptual model these cytokine dynamics depicted fig
Просмотров: 601 BEST HEALTH Answers
PRECISION exonerates celecoxib: cardiovascular risk is no worse than that of nonselective NSAIDs
 
03:25
Read the article here: http://bit.ly/2mlOPAS NEW ORLEANS – The cardiovascular safety profile of the nonsteroidal anti-inflammatory drug (NSAID) celecoxib, a selective inhibitor of COX-2, is no worse than those of the nonselective NSAIDs naproxen and ibuprofen, according to a trial reported at the American Heart Association scientific sessions.
Bilirubin 2 - Bilirubin Metabolism & Diseases
 
05:20
http://www.handwrittentutorials.com - This tutorial is the second of the Bilirubin series. It explains the process of Bilirubin Metabolism in the liver. This tutorial also discusses the hereditary diseases associated with failure of metabolism. For more entirely FREE medical tutorials and accompanying PDFs visit http://www.handwrittentutorials.com
Просмотров: 148322 Handwritten Tutorials
Lalita Ramakrishnan (Cambridge) 3: Tuberculosis as an Inflammatory Disease
 
32:27
https://www.ibiology.org/human-disease/tuberculosis-pathogenesis/#part-3 Lalita Ramakrishnan gives an introduction to tuberculosis (TB) pathogenesis, gives an overview of Mycobacterium tuberculosis’ life cycle, and explains how the TB bacteria gain entry into the host. Part 1: An Introduction to Tuberculosis: The Pathogenic Personality of the Tubercle bacillus: Lalita Ramakrishnan gives an introduction to tuberculosis (TB) pathogenesis, and gives an overview of Mycobacterium tuberculosis’ life cycle. Part 2: The Troublesome Tubercle in Tuberculosis: After the tuberculosis (TB) bacteria infect macrophages, a complex structure called a granuloma develops. Ramakrishnan explains how her laboratory used a zebrafish model of TB to study the involvement of granulomas in TB progression. Part 3: Tuberculosis as an Inflammatory Disease: Lalita Ramakrishnan’s laboratory has studied the molecular pathogenesis of TB using the power of forward genetics in the zebrafish. Talk Overview: In this seminar, Dr. Lalita Ramakrishnan gives an introduction to tuberculosis (TB) pathogenesis, and gives an overview of Mycobacterium tuberculosis’ life cycle. She explains how the TB bacteria gain entry into the host by using specific lipids to avoid microbicidal macrophages and recruit growth-permissive ones. Once inside the macrophage, the bacteria use multiple virulence genes to survive intracellularly. In particular, Ramakrishnan discusses bacterial efflux pumps that, in addition to promoting intracellular survival, also induce tolerance to multiple antibiotics. Most individuals have effective counterstrategies so that they are able to clear TB infection by a combination of innate and adaptive immunity. Yet scientists have not been able to understand these defense strategies enough to harness them and create an effective vaccine against TB. After the TB bacteria infect macrophages, a complex structure called a granuloma develops. Different immune cells arrive at the granuloma to surround the bacterial infection and fight the disease. In her second lecture, Ramakrishnan explains how her laboratory used a zebrafish model of TB to study the involvement of granulomas in TB progression. Although granulomas were thought to constrain infection, her laboratory showed that the bacteria hijack the granulomas to spread the disease. For example, Ramakrishnan showed that TB bacteria promote the recruitment of new macrophages to the granuloma that engulf dying infected macrophages to expand infection. Ramakrishnan’s laboratory has studied the molecular pathogenesis of TB using the power of forward genetics in the zebrafish. They discovered that mutations in LTA4H, a key enzyme in the eicosanoid pathway that alters the levels of the cytokine tumor necrosis factor (TNF), affect tuberculosis pathogenesis by regulating the inflammatory response. This work showed that a balance of TNF is required for good TB prognosis, and neither high nor low inflammation was favorable. Correspondingly, they showed that genetic variation in LTA4H in humans helps explain patterns of TB meningitis survival when patients were exposed to a treatment that suppresses the inflammatory response. Speaker Biography: Dr. Lalita Ramakrishnan is a professor of immunology and infectious diseases at the University of Cambridge, UK. She received her medical degree from the Baroda Medical College in India, and her PhD in Immunology from Tufts University in Boston. After completing her medical residency at Tufts and a fellowship in Infectious Diseases at the University of California, San Francisco, she joined the lab of Dr. Stanley Falkow at Stanford University as a postdoctoral fellow.  There she developed Mycobacterium marinum as a model for to study tuberculosis pathogenesis. She then joined the faculty at the University of Washington, where her laboratory developed the zebrafish infected with M. marinum as a model for tuberculosis. In 2014, she moved to the University of Cambridge, where her laboratory continues to unravel the molecular underpinnings of TB pathogenesis. Ramakrishnan’s work has been recognized with several awards and honors, including the NIH Director’s Pioneer Award, the Wellcome Trust Principal Research Fellowship and election to the US National Academy of Sciences (2015). Learn more about Ramakrishnan’s research here: https://www.med.cam.ac.uk/ramakrishnan/
Просмотров: 2105 iBiology
Dr.Ahmed Abd El-Rahman - C.V.S 1 - Angina Pectoris
 
51:09
Subject : Pharmacology Tuesday - 3rd, December 2013 Contents :- Angina Pectoris - Types of Angina Pectoris - Drug treatment of Angina * Organic Nitrates
Просмотров: 16940 Kasr Al-Ainy - 3rd Year (2011-2017) Channel
NSAIDs - Putting Risk into Perspective
 
06:11
This video outlines the benefits and risks of using NSAIDs to treat osteoarthritis. It specifically focuses on the cardiovascular and gastrointestinal risks putting them into perspective for everyone to understand.
Просмотров: 506 RheumInfo
Optimal Living Program Chapter One: Polyunsaturated Fats
 
02:48
Learn how polyunsaturate fats impact cancer risk, inflammation and heart disease. More information @ http://www.meschinohealth.com/LP/Building_A_Nutrition_Foundation
Просмотров: 473 Dr.James Meschino
Enzymes in Liver diseases (Case discussion of Infectious hepatitis and Obstructive jaundice)
 
12:35
for Medical and Dental students for NEET PG preparation 1.ALT - specific to liver diseases 2. AST- nonspecific, also increases in heart ds 3. ALP - 2 - 3 times of normal in hepatitis and 10 -12 times of normal in Obstructive jaundice 4. 5'NT- Obstructive pathology 5. GGT- specific for alcoholic liver ds Books Tietz, Harper, Vasudevan, Rafi, Satyanarayana etc.
Просмотров: 209 Biochemistry by Dr Rajesh Jambhulkar
What is the link between aspirin and asthma?
 
08:47
An outline of the role of aspirin in exacerbation of asthma in patients with aspirin induced asthma and rhinitis (Samter's triad) produced for IMG SOS - http://www.imgsos.com.au https://www.facebook.com/imgsos/ https://www.facebook.com/groups/imgsos.studygroup/
Просмотров: 1195 Lyndal Parker-Newlyn
Episode 166 -- Polyunsaturated fatty acids (PUFA) and their effects on human body -- Healthy Living
 
10:41
Are so called essential fatty acids truly essential? It's believed that PUFAs suppress the function of thyroid along with myriad of other side effects. Aram and Ruben share their wisdom.
Просмотров: 3865 Aram Hovsepian
NSAIDs and risk of stroke -Video abstract 54159
 
03:23
Video abstract of Review paper "Risk of stroke associated with nonsteroidal anti-inflammatory drugs" published in the open access journal Vascular Health and Risk Managment by Park K and Bavry AA. Abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs), both cyclooxygenase (COX)-2-selective and nonselective agents, have been associated with the increased risk of adverse cardiovascular events. The majority of studies have focused on myocardial infarction as the primary cardiovascular outcome. However, the association between NSAIDs and the risk of stroke events is not as clear, although an understanding of this association is important since stroke continues to be a significant cause of morbidity and mortality. Various factors may contribute to an association between NSAIDs and stroke, including hypertension and thrombosis. Additionally, the risk may vary with different NSAID types. In this review, we discuss the relevant literature assessing the possible association between NSAID use and stroke events, along with the potential mechanisms and the possible directions for future study. Read the Review paper here: http://www.dovepress.com/risk-of-stroke-associated-with-nonsteroidal-anti-inflammatory-drugs-peer-reviewed-article-VHRM
Просмотров: 525 Dove Medical Press
Pharmacology ,  1 , HISTAMINES , Autocoids
 
06:18
Просмотров: 18260 Rajeev Ranjan Gupta
Are PUFAs Making Your Fat Stores Toxic?
 
09:32
Wait... You don't know your Metabolism Score? Take the quiz and find out: https://our.typeform.com/to/D1PB3B *Studies:* A mathematical relationship between the fatty acid composition of the diet and that of the adipose tissue in man. - http://www.ncbi.nlm.nih.gov/pubmed/7355785
Просмотров: 1284 Amplified Metabolism
UF study strengthens concerns about long-term use of certain painkillers
 
01:56
Painkillers such as ibuprofen, naxopren and celecoxib provide needed relief for many patients who have chronic pain. But an ongoing source of contention is whether those drugs and others in their class known as nonsteroidal anti-inflammatory drugs, or NSAIDs, are linked to harmful health effects. Now a new study from the University of Florida raises the concern about potential risks to a higher degree than before, finding a doubling of deaths from heart attack, stroke and related events among people who have both hypertension and coronary artery disease and use the drugs long term. The findings, based on data from the international INVEST clinical study of hypertension therapies, are published in the current issue of The American Journal of Medicine. "It does strengthen our practice recommendations," said lead author Anthony A. Bavry, M.D., M.P.H., an assistant professor of cardiovascular medicine in the UF College of Medicine's department of medicine. Physicians already discourage the use of NSAIDs among the elderly and after heart attacks, on the basis of several studies showing that the drugs are linked with a higher risk of stroke and heart attack. But the UF researchers, including senior author Carl J. Pepine, M.D., a professor of cardiovascular medicine in the UF College of Medicine, advise patients to talk to their doctors before stopping use of prescribed treatments. "It's a tricky issue, because NSAIDs are useful for relieving pain, and that is much of what we do in medicine — alleviate pain and suffering," said Deepak L. Bhatt, M.D., M.P.H., an associate professor of medicine at Harvard Medical School and chief of cardiology at the VA Boston Healthcare System, who recently published findings that NSAIDs are linked to a higher risk of stroke. "Unfortunately, most medications have some potential side effects, and it's important to know what those might be." Bhatt was not involved in the UF study. Patients who have both high blood pressure and coronary artery disease are generally put on aspirin, a unique type of NSAID, to reduce their risk of a heart attack. Physicians are concerned that giving those patients other NSAIDs for pain relief could cancel out aspirin's beneficial effects and raise the risk of negative cardiovascular effects. The UF research team took advantage of the availability of INVEST study data from 882 chronic NSAID users and almost 22,000 intermittent or nonusers to try to settle the question. They looked at patients who reported using NSAIDs over an average of about three years, to see whether there was an increase in adverse events or cardiovascular-related death compared with patients who did not use those pain medicines long term. The risk of death from cardiovascular causes was 2.3 times higher among patients who chronically used the drugs than among other patients. NSAIDs are thought to act in a variety of ways to increase cardiovascular risk. They are thought to prevent aspirin's protective anti-clotting effect by preventing the aspirin from binding properly to platelets in the blood. Some NSAIDs might also increase bleeding risk. In addition, NSAIDs raise blood pressure, thus potentially raising the risk of heart attack and stroke. Some NSAIDs have already been removed from the market because of concerns about an elevated risk of heart attack and stroke.
Просмотров: 8717 UFHealth
PROSTANOIDS ACTIONS ON CARDIAC HYPERTOPHY
 
02:40
Просмотров: 135 drjepm
Gastrointestinal Risk with NSAIDs
 
06:14
NSAID stands for non-steroidal, anti-inflammatory drug. These are anti-inflammatory medicines, medicines which decrease inflammation. They are typically used to treat pain, arthritis, and are commonly taken for either the short term or the long term. Most NSAIDs have stomach side effects because they decrease your body's natural protection against acid in the gastrointestinal tract. Additional important FDA safety information on NSAIDs: http://www.fda.gov/CDER/drug/infopage/COX2/NSAIDmedguide.htm Made possible by a grant from Pfizer, Inc.
Просмотров: 14777 AmerGastroAssn
NSAIDs & GI Side Effects | TYLENOL® Professional
 
00:35
See how non-steroidal anti-inflammatory drugs (NSAIDs) can affect gastric mucosal protection, which can lead to GI side effects such as irritation and bleeding. For more information, visit TylenolProfessional.com. This video is intended for U.S. healthcare professionals only.
Просмотров: 11267 TYLENOLOFFICIAL
Prostaglandins and Their Inhibitors
 
47:48
Garret A. FitzGerald, M.D. Professor Medicine and Systems Pharmacology and Translational Therapeutics Perelman School of Medicine University of Pennsylvania Associate Dean Translational Research Perelman School of Medicine University of Pennsylvania
Просмотров: 183 UCLA CTSI
What is the link between aspirin and asthma ?
 
08:51
A short #FOAMed video about the interesting pharmacology of aspirin and its role in exacerbating symptoms of asthma, allergic rhinitis and nasal polyps.
Просмотров: 4675 Lyndal Parker-Newlyn
Lp-PLA2 Activity Testing: The Clinical and Laboratory Perspective
 
41:58
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a novel biomarker of atherosclerosis and is often referred to by the trademark name “The PLAC Test.” Lp-PLA2 is an enzyme produced mainly by monocytes and macrophages that converts phosphotidylcholine into 2 proinflammatory and proatherogenic molecules: nonesterified fatty acids (NEFA) and lysophosphatidylcholine (LPC). After attending, participants should be able to: - Define Lp-PLA2, where it can be found, as well as understand why it is a good marker for coronary heart disease risk - Describe how Lp-PLA2 is measured in the laboratory - Explain the difference between Lp-PLA2 activity assay and Lp-PLA2 concentration assay - Identify why the activity assay is preferred over the concentration assay - Understand how and when to use the Lp-PLA2 activity assay to modify patient management - Understand how to order the test from Mayo Medical Laboratories
Просмотров: 864 Mayo Clinic Laboratories
Quiz Prostaglandins by Dr Sunita Maheshwari
 
32:23
Pediatric Cardiology Teaching, Class, Lecture conducted by Dr Sunita Maheshwari. The topic is - Quiz on Prostaglandins.
Просмотров: 783 People4People
Correct Arachidonic Acid Levels
 
02:14
Correct Arachidonic Acid Levels Dr. Barry Sears is a leading authority on the impact of the diet on hormonal response, genetic expression, and inflammation. A former research scientist at the Boston University School of Medicine and the Massachusetts Institute of Technology, Dr. Sears has dedicated his research efforts over the past 30 years to the study of lipids. He has published more than 30 scientific articles and holds 13 U.S. patents in the areas of intravenous drug delivery systems and hormonal regulation for the treatment of cardiovascular disease. He has also written 13 books, including the New York Times #1 best-seller "The Zone". These books have sold more than 5 million copies in the U.S. and have been translated into 22 different languages. For more, go to zonediet.com
Просмотров: 4295 Dr. Barry Sears
Parkinson's Disease and Alzheimer's Disease
 
56:30
This Lecture talks about Parkinson's Disease and Alzheimer's Disease
Просмотров: 589 Cec Ugc