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Muscle Loss and Aging
 
05:53
Mayo Clinic Dr. Nathan LeBrasseur discusses muscle loss during the aging process and also looks at strategies and therapies to maintain muscle health.
Просмотров: 14593 Mayo Clinic
How to Rebuild Muscle After Wasting Away
 
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How to Rebuild Muscle After Wasting Away. Part of the series: LS-The Ultimate Outdoor Workout. Rebuilding muscle after wasting away is something you would have to do if you haven't been to the gym in awhile. Rebuild muscle after wasting away with help from a certified personal trainer in this free video clip. Read more: http://www.livestrong.com/video/1008772-rebuild-muscle-after-wasting-away/
Просмотров: 1716 LIVESTRONG.COM
Improving Muscle Health
 
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Nathan K. LeBrasseur, M.S., Ph.D., Associate Professor and Co-Chair of Research in the Department of Physical Medicine and Rehabilitation, Mayo Clinic College of Medicine, discusses age- and disease-associated muscle loss. Most of us will lose 30-percent of our muscle mass between our 40’s and 80’s and that has severe implications for our physical function, susceptibility to diabetes, and resiliency to multiple forms of stress. Improving muscle health is important. In addition to exercise, he is also researching the muscle-derived protein myostatin. It is a negative regulator of muscle mass. If its activity is not regulated it can actually cause deterioration and wasting of skeletal muscle. He and other researchers are looking at ways to block myostatin activity to increase muscle mass and, in turn, improve strength, physical function, and whole body metabolism, and reduce frailty, in persons with poor muscle health due to aging and chronic disease.
Просмотров: 871 Mayo Clinic
7 Exercises You Should Do Absolutely Every Day.
 
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"Famous" Physical Therapists Bob Schrupp and Brad Heineck demonstrate 7 exercises you should do absolutely every day. Make sure to like us on FaceBook https://www.facebook.com/BobandBrad/ Check out the Products Bob and Brad LOVE on their Amazon Channel: https://www.amazon.com/shop/physicaltherapyvideo Follow us on Twitter https://twitter.com/PtFamous Our Website: https://www.bobandbrad.com/ Our book “Three Simple Steps To Treat Back Pain” is available on Kindle http://www.amazon.com/Three-Simple-Steps-Treat-Back-ebook/dp/B00BPU4O5G/ref=sr_1_1?ie=UTF8&qid=1444092626&sr=8-1&keywords=3+simple+steps+to+treat+back+pain Brad’s Book “Martial Arts Manual: For Stretching, Strengthening, Prevention, and Treatment of Common Injuries” is also available on Kindle. https://www.amazon.com/Martial-Arts-Manual-Stretching-Strengthening-ebook/dp/B0722J3PZL/ref=sr_1_fkmr0_1?ie=UTF8&qid=1494292881&sr=8-1-fkmr0&keywords=brad+heineck+martial+arts WANT TO HELP TRANSLATE OUR VIDEOS? We would so love the help. http://www.youtube.com/timedtext_cs_panel?tab=2&c=UCmTe0LsfEbpkDpgrxKAWbRA
Просмотров: 683418 Physical Therapy Video
Sarcopenia (Medical Condition)
 
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Symptoms, risk factors and treatments of Sarcopenia (Medical Condition) Sarcopenia is the degenerative loss of skeletal muscle mass, quality, and strength associated with aging This video contains general medical information If in doubt, always seek professional medical advice. The medical information is not advice and should not be treated as such. The medical information is provided without any representations or warranties, express or implied. We do not warrant or represent that the medical information on this websiteis true, accurate, complete, current or non-misleading Music: 'Undaunted' Kevin Macleod CC-BY-3.0 Source/Images: "Sarcopenia" CC-BY-2.5 https://www.freebase.com/m/08rzmg
Просмотров: 231 Medical Condition Information
Exercise Center Overview
 
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Dr. Manno informs us on the background of the Johns Hopkins Rheumatology Exercise Center, as research was focused on muscle building exercises and their effects on systemic inflammatory rheumatic disease patients.
Просмотров: 12 Johns Hopkins Rheumatology
How Strength Training Helps Your Health
 
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Strength training has many health benefits. In this Health Smarts video, fitness expert Mike Clark, DPT, explains how resistance training help prevent diabetes, osteoporosis, and back pain, as well as age-related muscle loss.
Просмотров: 34 ThePostGame
A Strong Will to Heal Cachexia and Gaining a Sense of Peace
 
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Farm of Life (www.farmoflifecr.com) guest Martin spent 2 months on a personal wellness journey to heal Cachexia, which is a metabolic dysfunction effecting cell communication, and assimilation of nutrition. Martin speaks about the life changing moments he had, being connected to nature and Self and a 7-day water fast. He departs having found much more physical strength and a deep sense of peace.
Просмотров: 2473 FarmofLife
Yaşlılarda hangi ROMATİZMAL hastalıklar daha sık görülür ? -  Prof. Dr. Ahmet AKGÜL
 
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Romatolojik hastalıklar yaşlılarda hekime başvuru nedenleri arasında ön sıralarda yer almakta ve bu grupta klinik olarak atipik seyir izleyebildiği gibi ek hastalık, çoklu ilaç kullanımı, ilaç etkileşimlerinden dolayı tedavide de farklılıklar oluşmaktadır. Yaşlı hastalarda sık görülen romatolojik hastalıklar arasında osteoartrit, romatoid artrit, Sjögren hastalığı, temporal arterit ve polimiyalji romatika yer almaktadır. En sık başvuru nedeni ise ağrıdır. Yaşlı bireylerde ağrı; depresyon, sosyal izolasyon, uyku problemleri ve aktivitenin bozulmasına neden olmaktadır. Aktivitenin bozulmasından dolayı hem düşme olayları hem de sarkopeni ile karşılaşabiliriz. Yaşlılarda uygunsuz ilaç kullanımı, komorbiditenin fazla olması, polifarmasi, farmakodinamik ve farmakokinetik değişiklikler nedeniyle ilaçların etkinliği ile toksik dozları genç hastalardan belirgin farklılıklar göstermektedir. Rheumatologic disorders are one of the most common disorders causing admission to the hospital in the elderly and in this population clinical presentation of these disorders may be atypical and also, treatment may be different due to having multiple co-morbidities, polypharmacy and drug-drug interactions. The most frequent rheumatologic disorders in the elderly are osteoarthritis, rheumatoid arthritis, Sjögren's disease, temporal arthritis and polymyalgia rheumatica. The major clinical presentation is pain. Pain may be associated with depression, social isolation, sleep disorders and impairment of physical activities in this population. Impaired physical activity may also cause falling and sarcopenia. Efficiency and toxicity of drugs may be different in elderly patients causing by the reasons of inappropriate drug usage, having multiple co-morbidities, polypharmacy, pharmacodynamic and pharmacokinetic changes.
Просмотров: 198 Ahmet Akgül Prof Dr 00 90 532 4884474
Tips bij verminderde spierkracht, obesitas en type-2-diabetes/ sarcopenie/ Reumatoïde artritis
 
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verminderde spierkracht bij obesitas en type-2-diabetes/ sarcopenie/ Reumatoïde artritis www.easysteppers.nl simpel traplift alternatief Wanneer traplopen een probleem wordt, heb je traditioneel keuze uit 3 'prijzige en ingrijpende' oplossingen: traplift, verbouwen of verhuizen. Het probleem van deze oplossingen is dat men de spieren niet meer belast, een inactief leven krijgt en dat als gevolg hiervan (verdere) (lichamelijke) achteruitgang versneld verloopt. Met de Easysteppers is er nu een 4e optie bijgekomen. De Easysteppers bieden de mogelijkheid dat u, ondanks uw beperkingen, kunt blijven traplopen en uw spieren blijft trainen. Op deze wijze blijft u dagelijks aan uw conditie werken en voorkomt daarmee dat u te kwetsbaar wordt om in uw eigen woning te blijven wonen.
Просмотров: 260 Wil Peters
Chronic painful muscle wasting disease healed after 20 years - John Mellor Healing Ministry
 
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Chronic painful muscle wasting disease healed after 20 years - John Mellor Healing Ministry. http://www.johnmellor.org. John Mellor, an International Australian Healing Evangelist. John Mellor has a gift of healing and miracles with a ministry of praying for the sick in Jesus' name. John Mellor sees many miracles and healings of every type of physical illness, emotional disorder and mental illness. John Mellor sees hundreds more testimonies at our YouTube Channel, John Mellor Ministries. If you would like to find out where John Mellor is ministering, see his itinerary at www.johnmellor.org.
Просмотров: 502 John Mellor
Treating cachecia with anamorelin: 24-week follow-up data from ROMANA studies
 
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David Currow, BMed, PhD, MPH, FRACP, FAChPM, FAHMS, GAICD of Flinders University, Adelaide, Australia, discusses anamorelin in ROMANA 1 and ROMANA 2 studies. Anamorelin acts as a selective ghrelin receptor agonist and has a potential to increase lean body mass, appetite, and fat mass in people with cancer cachexia. Dr Currow highlights the 24-week follow-up data from ROMANA studies showing increase in lean body mass and fat mass, and decrease in anorexia, which was maintained in the anamorelin-treated study arm. Cachexia is one of the prognostic factors in cancer and Dr Currow sees this as a tremendous opportunity to open a new therapeutic corridor, which allows us to treat cachexia alongside the disease. Recorded at the Multinational Association of Supportive Care in Cancer (MASCC) 2016 Annual Congress in Adelaide, Australia.
Просмотров: 64 VJOncology
Fighting Frailty as You Age
 
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The BIT's Global Health Conference is held annually in Taiyuan, China. This year Tim is speaking on a topic most people never even think about, or indeed consider possible...
Просмотров: 22 Tim Bean
ULH 2014 Research Presentation Session 2
 
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Session 2‐ Chairs: Dr Damien Ryan and Dr Mary Clarke Moloney The effectiveness of an outpatient Multidisciplinary Pulmonary Rehabilitation Programme on physical fitness, psychological well‐being and self‐management of respiratory symptoms in patients with Chronic Obstructive Pulmonary Disease. Presenter: Catherine Quinn Self‐Instructional Infant CPR training for expectant women and their partners within the Maternity Services Presenter: Meabh Barry A Cluster Analysis of Sleeping patterns of 9‐month old infants and the association with maternal health: Results from a population based cohort study. Presenter: Aoife Hughes Comparing cardiovascular risk factors, disease and treatment in participants with rheumatoid arthritis, osteoarthritis and without arthritis in a population based study. Presenter: Neil O Driscoll Sarcopenia: DXA‐based criteria of age‐related change in lean tissue mass. Presenter: Phil Jakeman Is Low Skeletal Muscle Mass Synonymous with Sarcopenia? Presenter: Edric Leung
Просмотров: 629 UniversityofLimerick
Happy Family Health Lecture - Osteoporosis - Protecting Your Bones (Jeneth Cortez)
 
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Tagalog/Filipino Health Lecture 00001.MTS
Просмотров: 240 winelfredpasamba
Muscle Mass - Dr. Joel Wallach
 
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http://www.wallachslog.com Call: 1(774) 322-1690 Dr. Joel Wallach's Books: http://amzn.to/1lCtpzq Dr. Joel Wallach’s Products : http://bit.ly/1U2F355 Dr. Joel Wallach takes a call from Kim who has concerns over loosing muscle mass. Turn your dreams into reality....Join us in the crusade to take back your health and your Freedom! Message Me or Visit: http://bit.ly/WGP1uJ http://bit.ly/1v3EzPi Call Me at 1(774) 322-1690 For more information! Subscribe to my Youtube channel: http://bit.ly/1yqARxp Follow Me on TWITTER - http://bit.ly/1LEFzC4 Friend Me on FACEBOOK - http://on.fb.me/18pBC2b G+: http://bit.ly/1LNb8tm Dr. Joel Wallach's Books: http://amzn.to/1lCtpzq Order Dr. Joel Wallach’s Products : http://bit.ly/1U2F355 Disclaimer: These statements have not been reviewed or approved by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Просмотров: 33359 M Medeiros
Acute Skeletal Muscle Wasting in Critical Illness
 
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JAMA. 2013;310(15):1591-1600. doi: 10.1001/jama.2013.278481. Read the article here: http://ja.ma/18LJ5K4
Просмотров: 649 JAMA
Measuring function in cancer patients: do we need disease- or sarcopenic-specific measures?
 
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In this presentation during the September 2017 workshop on Understanding the Role of Muscle and Body Composition in Studies of Cancer Risk and Prognosis in Cancer Survivors, Dr. Woodhouse discusses measurements of activity and physical function in cancer patients with sarcopenia. She contends that condition-specific and performance-based measures will help us to better understand changes in muscle mass and better evaluate our interventions. https://epi.grants.cancer.gov/events/sarcopenia/
Просмотров: 33 NCIwebinars
10/19/2015 - Session 2: Discussion
 
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Panelists field questions from the audience.
Просмотров: 77 NASEM Health and Medicine Division
Session 2 Panel: Aging: Changes in Muscle and Bone, Linkages and Shared Etiologies
 
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All Session 2 speakers and chairs -Eric Orwoll, M.D., Oregon Health and Science University, Portland, Oregon, USA -Roger A. Fielding, Ph.D., Tufts University, Boston, Massachusetts, USA -Stephanie A. Studentski, M.D., M.P.H., University of Pittsburgh, Pittsburgh, Pennsylvania, USA -Clifford J. Rosen, M.D., Maine Medical Center Research Institute, Scarborough, Maine, USA This panel was held at the ASBMR Topical Meeting on July 17, 2012 in Kansas City, MO, USA. For more information about ASBMR and bone research related events, visit http://www.asbmr.org.
Просмотров: 277 asbmradmin
Patient-reported outcomes, biomarkers and novel methodologies...
 
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Patient-reported outcomes, biomarkers and novel methodologies, and their role in the development of new treatments for MS Speaker: Frank Dahlke, Novartis (EFPIA) Session 3: Patient-reported outcomes, biomarkers and novel methodologies, and their role in the development of new multiple-sclerosis drugs Workshop on the clinical investigation of new medicines for the treatment of multiple sclerosis
Просмотров: 134 emainfo
Chronic Fatigue and Bioidentical Hormone Pellets
 
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http://drkathymaupin.com/treating-chronic-fatigue-with-bioidentical-hormone-pellets
Просмотров: 1825 BioBalanceHealthcast
Prevent and Reverse Osteoporosis and Osteopenia
 
09:06
http://180degreehealth.com for more. Get out of the catabolic state of old age and back into the growth state of your youth by doing what has been known since the beginning of time to trigger growth - eating more and increasing your strength.
Просмотров: 7161 180degreehealth
How I Rebuilt My Life With Ed Strachar of Healing Genius
 
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If you want to learn how to transform your life, visit our website: www.healinggenius.com. Hi. I'm Diana Dentinger. I will tell you my experience working with Ed Strachar. Ahh couple of years ago I went through let’s say pretty easy divorce compared to the seven years of living with my ex-husband who was chronically depressed and there was just this whole dynamics of energy drain in our home and that was really really tough loving someone and trying to support them but you know not being able to and realising that ahh if I couldn't save the relationship at least I had to save myself. So, after the divorce and like I said that was pretty easy, ahh I was I was really out of energy. So you know I’m a single mom raising four kids and I, I knew that there was ahh there was something that I have to do first I couldn’t just mentally talk myself into feeling better and I couldn’t just emotionally find things to be happy and grateful for even though that is the big part of it. You know I’ve been in the corporate training ahh in personal development industry for 25 years. So I know all about how to change the mindset, how to change belief system, how to connect with who I am how to have the emotions, I know all that stuff. But there’s that element of energy that I wasn’t in expert in and I was so lucky to have found Ed through friends on Facebook. I tell you one thing haha its, really difficult to describe the experience of working with Ed but the idea of you know imagine just being deflated and then having a couple of sessions with Ed and all of a sudden reinflated. It was such a powerful actually life-saving experience. I mean when I, when I talk to friends and they said, God, you were evolved and got so much energy how was that and I said I really, I really do ah oh my physical, mental, emotional, spiritual condition to the techniques that I worked working with Ed Strachar. So after that was back like in November got my energy realigned ahh it opened up to speaking international speaking engagements ahh in this past couple of years then you know moved couple of times found a dream houses to live in with my kids ahh I’ve been traveling more had some amazing high-end clients and created a new coaching methodology, you know written and published some book. So I, I have really taken off and I find and I am sure 100% that ahh really thanks to the kind of energy connection work that Ed Strachar does. And I was really fortunate to have reconnected with him because I’m up leveling all the time, ahh you know starting some crowd funding getting out there even more. And there’s ah you know you you have to feel this in your own life where you know there’s the next level but there’s a sort of a ceiling, there’s a ceiling and the only way to break through it is energetical. And yeah, thanks to Ed again I feel like I’ve really broken through that next to that next level energetically with even more you know confidence, determination to get my message out there, ahh the practices that he has are far from a guru. He has just a really direct and I like because he is a no bullshit person so we got along really well because I like the telekinetic stuff. Yet he has this enormous heart of just a love space that is admirable and I believe that ahh that even you know this connection and him helping me get to the next level is and has been really vital and will continue to be vital because the techniques that he taught me are how to be autonomous in re-energizing myself, my home, my business, my family and so this is an invitation and you know, ah ah heartfelt invitation. If you feel low in energy and depleted take it from me as a personal development coach sometimes you can’t just get there by changing your mindset or making your gratitude less even though that helps. Sometimes there is this invisible kind of ceiling and you it’s just it’s just something you perceive.... To know more about how to transform your life, connect with us on our Facebook page: https://www.facebook.com/EdStracharSpiritHealer
Просмотров: 311 Healing Genius
Presentation: I-SPY 2 Trial
 
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Presentation: I-SPY 2 Trial Monday, November 04, 2013 10:15am
Просмотров: 485 FasterCures
Sunrise Tai Chi: Simplified Tai Chi For Health and Longevity - MAEQD.com
 
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**SPECIAL OFFER** As a special thank you for watching this video. If you check out the Sunrise Tai Chi: Simplified Tai Chi For Health and Longevity at MAEQD.com today, you can use the following coupon code to get a special discount off your entire order. Coupon Code: YOUTUBEVIEWER159753 Click Here: http://www.maeqd.com/product-5936-sunrise-tai-chi-simplified-tai-chi-for-health-and-longevity.html?utm_source=youtube&utm_medium=video&utm_campaign=treepodia For the latest pricing information please see the product page at the link above. Product Description: About this book: Awaken, Heal, and Strengthen Your Mind, Body & Spirit. Each day, millions of people worldwide practice Tai Chi Chuan, which has been known for centuries to promote deep relaxation and excellent health, to prevent injuries and illnesses, and to improve martial skills. Tai Chi has steadily become a popular form of Mind/Body exercise as more and more people in the west discover the rich rewards of living in a holistic way. Tai Chi is a journey through the mind, the body, and the spirit, that can be practiced by everyone. Increasingly, you can see people practicing in the park - moving slowly in a meditative state, or even perfecting their martial arts skills. But, what is Tai Chi really? This book clearly introduces the history and underlying principles of Tai Chi Chuan (taijiquan) from a modern and unique perspective. For the beginner, this program is a comprehensive introduction to authentic Tai Chi, allowing you to fine-tune your Mind/Body skills and create balance among them. For the intermediate and advanced, it includes important directions and instructions, helping you improve and expand Mind/Body knowledge. In the end, you will understand and experience the ultimate goal of Tai Chi; the harmonizing of the three forces - human, earth, and heaven. The Sunrise Tai Chi form is the protocol used at Tufts School of Medicine for the R-21 studies of healing rheumatoid osteoarthritis of the knee with tai chi. * Develop symmetry and balance between strength and flexibility. * Loosen and strengthen muscles, tendons, and ligaments. * Improve circulation of blood and Qi energy. * Learn how to increase bone density. * Massage internal organs with gentle movement. * Boost your immune system to help heal chronic conditions, including Arthritis, Osteoperosis, Sarcopenia, and Cancer. * Improve your quality of life and daily physical performance. * Tap into the abundant energy of the universe. * Learn and improve your martial arts skills. About the Author: A senior disciple of renowned teacher & author Dr. Yang, Jwing-Ming, PhD in Boston, MA, Ramel is a Gold medalist in Internal and External Martial Arts: Three-Time Gold Medalist in Shanghai China, for Tai Chi, External & Internal Weapons (Grand National Championship 1994) & Gold Medalist for Tai Chi & Kung Fu Sword, 1994. From 1991-1993, Ramel earned Gold Medals for Tai Chi, Pushing Hands and Tai Chi Sword in the International North American Chinese Martial Arts Competition. David Silver has had a lifelong interest in meditation, and began training Goj? Ryu Karate at age 11. He studied Taijiquan, Qigong, and Yoga in his 20's, and became certified to teach Qigong by Dr. Yang, Jwing-Ming in 2006. David works as a writer, producer, and director of instructional martial arts and health books and DVDs. He is the co-writer of the books and DVDs Sunrise Tai Chi, Tai Chi Energy Patterns, and Sunset Tai Chi. David lives on Cape Cod, MA. Product Details: * Author: David Silver and Ramel Rones * Foreword By: Miriam E. Nelson * Language: English * Format: Softcover * Pages: 199 * Publisher: YMAA Publication Center Book Dimensions: * Weight: 2 Pounds * Length: 14 Inches * Width: 12 Inches * Height: 0.5 Inches
Просмотров: 27 MAEQD
Day 1 - Appropriate Use of Drug Therapies for Osteoporotic Fracture Prevention
 
07:37:22
More than 10 million people in the United States have osteoporosis, a skeletal disorder that causes bones to become weak and fragile as a result of low bone mass. The condition makes people more susceptible to fractures, which can impair their ability to live independently and even threaten their lives. The social and economic burden of osteoporotic fractures is substantial. Reducing osteoporosis prevalence and hip fracture incidence are among the major objectives of Healthy People 2020, the U.S. Department of Health & Human Services’ national health promotion and disease prevention initiative. Lifestyle changes—including getting adequate nutrition and regular exercise, quitting tobacco use, limiting alcohol use, and preventing falls—can help reduce a person’s risk of osteoporotic fractures. However, medications may be prescribed to prevent fractures if a person has very low bone mineral density or has experienced a prior fragility fracture. The U.S. Food and Drug Administration has approved several types of drugs to prevent osteoporotic fractures. Clinical guidelines by various medical organizations recommend bisphosphonates (BPs) as a first line of treatment for most people who have osteoporosis. BPs are effective for short-term use (up to 3–5 years) by people who are at high risk of fracture. However, the benefits and risks of longer-term treatment are less clear. Reports of rare but serious adverse events such as atypical femoral fractures and osteonecrosis (death of cells) of the jaw have raised questions about the safety of osteoporosis drug use, especially in people who use the drugs for more than 3–5 years or who had a low risk of fracture when they began treatment. Research Challenges There is a gap in scientific data about the appropriate long-term use of many osteoporosis drugs. There are uncertainties about which people will benefit or may be harmed if they take the drugs long-term. Public concern about these and other unanswered questions has coincided with a significant decrease in use of osteoporosis drugs and a leveling off in what had been a promising decline in the incidence of osteoporotic fractures. These changes have raised concerns within medical and professional communities that many people who might need the drugs are not being prescribed them, and those who are prescribed them are not taking them. In addition, evidence is limited regarding the initiation and length of “drug holidays” (a medical practice in which a patient stops taking medications for a period of time and then resumes treatment again, if the patient or their doctor believes it could be in their best interests), whether stopping treatment reduces the risk of serious adverse events while maintaining fracture prevention benefit, and which individuals should change treatments instead of simply taking a drug holiday from their current medication. Innovative research strategies are needed to address these knowledge gaps and to help better inform individuals and physicians in their decision-making about osteoporosis treatment. Workshop Goals This P2P workshop will assess the available scientific evidence to better understand the appropriate use of drugs for osteoporotic fracture prevention, specifically addressing the following questions: What are the benefits and risks (including major adverse events) of osteoporotic drugs with short-term use (from first-use up to 3–5 years of treatment)? What factors influence outcomes? What are the benefits and risks of osteoporotic drugs over the longer term (for treatment periods longer than 3–5 years)? What factors influence outcomes? Do drug holidays improve outcomes? What patient and clinician factors impact the use of and adherence to osteoporotic drugs? Workshop Sponsors National Institute on Aging National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH Office of Disease Prevention
Просмотров: 72 NIH ODP
Breast Implants
 
18:06
Просмотров: 924 BioBalanceHealthcast
Day 2 - Appropriate Use of Drug Therapies for Osteoporotic Fracture Prevention
 
04:04:28
More than 10 million people in the United States have osteoporosis, a skeletal disorder that causes bones to become weak and fragile as a result of low bone mass. The condition makes people more susceptible to fractures, which can impair their ability to live independently and even threaten their lives. The social and economic burden of osteoporotic fractures is substantial. Reducing osteoporosis prevalence and hip fracture incidence are among the major objectives of Healthy People 2020, the U.S. Department of Health & Human Services’ national health promotion and disease prevention initiative. Lifestyle changes—including getting adequate nutrition and regular exercise, quitting tobacco use, limiting alcohol use, and preventing falls—can help reduce a person’s risk of osteoporotic fractures. However, medications may be prescribed to prevent fractures if a person has very low bone mineral density or has experienced a prior fragility fracture. The U.S. Food and Drug Administration has approved several types of drugs to prevent osteoporotic fractures. Clinical guidelines by various medical organizations recommend bisphosphonates (BPs) as a first line of treatment for most people who have osteoporosis. BPs are effective for short-term use (up to 3–5 years) by people who are at high risk of fracture. However, the benefits and risks of longer-term treatment are less clear. Reports of rare but serious adverse events such as atypical femoral fractures and osteonecrosis (death of cells) of the jaw have raised questions about the safety of osteoporosis drug use, especially in people who use the drugs for more than 3–5 years or who had a low risk of fracture when they began treatment. Research Challenges There is a gap in scientific data about the appropriate long-term use of many osteoporosis drugs. There are uncertainties about which people will benefit or may be harmed if they take the drugs long-term. Public concern about these and other unanswered questions has coincided with a significant decrease in use of osteoporosis drugs and a leveling off in what had been a promising decline in the incidence of osteoporotic fractures. These changes have raised concerns within medical and professional communities that many people who might need the drugs are not being prescribed them, and those who are prescribed them are not taking them. In addition, evidence is limited regarding the initiation and length of “drug holidays” (a medical practice in which a patient stops taking medications for a period of time and then resumes treatment again, if the patient or their doctor believes it could be in their best interests), whether stopping treatment reduces the risk of serious adverse events while maintaining fracture prevention benefit, and which individuals should change treatments instead of simply taking a drug holiday from their current medication. Innovative research strategies are needed to address these knowledge gaps and to help better inform individuals and physicians in their decision-making about osteoporosis treatment. Workshop Goals This P2P workshop will assess the available scientific evidence to better understand the appropriate use of drugs for osteoporotic fracture prevention, specifically addressing the following questions: What are the benefits and risks (including major adverse events) of osteoporotic drugs with short-term use (from first-use up to 3–5 years of treatment)? What factors influence outcomes? What are the benefits and risks of osteoporotic drugs over the longer term (for treatment periods longer than 3–5 years)? What factors influence outcomes? Do drug holidays improve outcomes? What patient and clinician factors impact the use of and adherence to osteoporotic drugs? Workshop Sponsors National Institute on Aging National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH Office of Disease Prevention
Просмотров: 32 NIH ODP